NEDD8-activating Enzyme

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  1. MLN4924, NEDD8 activating enzyme inhibitor
    CAS: 905579-51-3 Formula: C21H25N5O4S Molecular Weight: 443.53
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: M127498
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    IUPAC Name
    [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
    SMILES
    C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N
    InChIKey
    MPUQHZXIXSTTDU-QXGSTGNESA-N
    InChI
    1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-1show more
    Synonyms
    Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycycl...
  2. NAcM-OPT
    CAS: 2089293-61-6 Formula: C23H29Cl2N3O Molecular Weight: 434.4
    ● In Stock — US warehouse, ships to EU* Item #: N412335
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    IUPAC Name
    1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea
    SMILES
    CCCCN1CCC(CC1)N(CC2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)Cl)Cl
    InChIKey
    VPHJABWIKCBGMC-UHFFFAOYSA-N
    InChI
    1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)
    Synonyms
    N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)urea | Urea,N-​(1-​butyl-​4-​piperidinyl)​-​N'-​(3,�...
  3. NAcM-OPT
    CAS: 2089293-61-6 Formula: C23H29Cl2N3O Molecular Weight: 434.4
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N422536
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    IUPAC Name
    1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea
    SMILES
    CCCCN1CCC(CC1)N(CC2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)Cl)Cl
    InChIKey
    VPHJABWIKCBGMC-UHFFFAOYSA-N
    InChI
    1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)
    Synonyms
    N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)urea | Urea,N-​(1-​butyl-​4-​piperidinyl)​-​N'-​(3,�...
  4. TAS4464
    CAS: 1848959-10-3 PubChem CID: 124121703 Formula: C21H23FN6O6S Molecular Weight: 506.51
    ● In Stock — US warehouse, ships to EU* Item #: T414219
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    IUPAC Name
    4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]oxolan-2-yl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]pyrrolo[2,3-d]pyrimidine
    SMILES
    CCOC1=C(C(=CC=C1)F)C#CC2=CN(C3=NC=NC(=C23)N)C4C(C(C(O4)CNS(=O)(=O)N)O)O
    InChIKey
    TZTRUHFXPVXWRD-QTQZEZTPSA-N
    InChI
    1S/C21H23FN6O6S/c1-2-33-14-5-3-4-13(22)12(14)7-6-11-9-28(20-16(11)19(23)25-10-26-20)21-18(30)17(29)15(34-21)8-27-35(24,31)32/h3-5,9-10,15,17-18,21,27,show more
    Synonyms
    7H-​Pyrrolo[2,​3-​d]​pyrimidin-​4-​amine,7-​[5-​[(aminosulfonyl)​amino]​-​5-​deoxy-​β-​D-​ribofuranosyl]​-​5-​[2-​(2-�...
  5. TAS4464 hydrochloride
    CAS: 1848959-11-4 PubChem CID: 124121823 Formula: C21H24ClFN6O6S Molecular Weight: 542.97
    ◐ .Made to order · 8–12 wks Item #: T649656
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    IUPAC Name
    4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]oxolan-2-yl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]pyrrolo[2,3-d]pyrimidine;hydrochloshow more
    SMILES
    CCOC1=C(C(=CC=C1)F)C#CC2=CN(C3=NC=NC(=C23)N)C4C(C(C(O4)CNS(=O)(=O)N)O)O.Cl
    InChIKey
    CDCFJYCKNAWPTL-WVAMHNCPSA-N
    InChI
    1S/C21H23FN6O6S.ClH/c1-2-33-14-5-3-4-13(22)12(14)7-6-11-9-28(20-16(11)19(23)25-10-26-20)21-18(30)17(29)15(34-21)8-27-35(24,31)32;/h3-5,9-10,15,17-18,2show more
  6. ZM223 hydrochloride
    CAS: 2438679-27-5 Formula: C23H18ClF3N4O2S2 Molecular Weight: 538.99
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: Z659416
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  7. Pevonedistat hydrochloride
    CAS: 1160295-21-5 PubChem CID: 66576990 Formula: C21H26ClN5O4S Molecular Weight: 480
    ◐ .Made to order · 8–12 wks Item #: P651845
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    Technical Identifiers
    IUPAC Name
    [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate;hydrochloride
    SMILES
    C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N.Cl
    InChIKey
    HJKDNNXKYODZJI-BVMPOVDASA-N
    InChI
    1S/C21H25N5O4S.ClH/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18;/h1-4,7-8,12,14-15,18-19,27H,5-show more
    Synonyms
    MLN-4924-003 | MLN4924-003 | SulfaMic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]aMino]-7H-pyrrolo[2,3-d]...
  8. TAS4464
    CAS: 1848959-10-3 PubChem CID: 124121703 Formula: C21H23FN6O6S Molecular Weight: 506.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: T1495895
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

Which compounds are listed for NEDD8-activating Enzyme?
Compounds associated with NEDD8-activating Enzyme are grouped here under the Metabolic Enzyme/Protease classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does NEDD8-activating Enzyme sit within Metabolic Enzyme/Protease?
NEDD8-activating Enzyme is one target listing within the Metabolic Enzyme/Protease classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from NEDD8-activating Enzyme?
For compounds listed under NEDD8-activating Enzyme, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for NEDD8-activating Enzyme?
Browse the parent Metabolic Enzyme/Protease listing to reach targets neighbouring NEDD8-activating Enzyme, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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