PKG

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  1. RKRARKE
    CAS: 82801-73-8 PubChem CID: 134097 Formula: C38H74N18O10 Molecular Weight: 943.11
    ● In Stock — US warehouse, ships to EU* Item #: R276094
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    Technical Identifiers
    IUPAC Name
    (2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diamishow more
    SMILES
    CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N
    InChIKey
    OUKSKNTVYYVIMZ-DUJSLOSMSA-N
    InChI
    1S/C38H74N18O10/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-show more
    Synonyms
    AKOS024456827 | Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid | cGMP Dependent Kinase Inhibitor Peptide | ...
  2. PKG drug G1
    CAS: 374703-78-3 PubChem CID: 135402990 Formula: C13H11N3OS Molecular Weight: 257.31
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P423688
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    IUPAC Name
    4-hydroxy-5-[(Z)-(2-methylindol-3-ylidene)methyl]-1,3-dihydroimidazole-2-thione
    SMILES
    CC1=NC2=CC=CC=C2C1=CC3=C(NC(=S)N3)O
    InChIKey
    BPJCCABLAZZIEJ-RMKNXTFCSA-N
    InChI
    1S/C13H11N3OS/c1-7-9(6-11-12(17)16-13(18)15-11)8-4-2-3-5-10(8)14-7/h2-6,17H,1H3,(H2,15,16,18)/b9-6+
    Synonyms
    4-​Imidazolidinone,5-​[(2-​methyl-​1H-​indol-​3-​yl)​methylene]​-​2-​thioxo-
  3. PKG drug G1
    CAS: 374703-78-3 PubChem CID: 135402990 Formula: C13H11N3OS Molecular Weight: 257.31
    ● In Stock — US warehouse, ships to EU* Item #: P412207
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    Technical Identifiers
    IUPAC Name
    4-hydroxy-5-[(Z)-(2-methylindol-3-ylidene)methyl]-1,3-dihydroimidazole-2-thione
    SMILES
    CC1=NC2=CC=CC=C2C1=CC3=C(NC(=S)N3)O
    InChIKey
    BPJCCABLAZZIEJ-RMKNXTFCSA-N
    InChI
    1S/C13H11N3OS/c1-7-9(6-11-12(17)16-13(18)15-11)8-4-2-3-5-10(8)14-7/h2-6,17H,1H3,(H2,15,16,18)/b9-6+
    Synonyms
    4-​Imidazolidinone,5-​[(2-​methyl-​1H-​indol-​3-​yl)​methylene]​-​2-​thioxo-
  4. Rp-8-pCPT-cGMPS sodium
    CAS: 208445-07-2 PubChem CID: 139600533 Formula: C16H14ClN5NaO6PS2 Molecular Weight: 525.86
    ◐ .Made to order · 8–12 wks Item #: R287755
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    Technical Identifiers
    IUPAC Name
    sodium;2-amino-8-(4-chlorophenyl)sulfanyl-9-(7-hydroxy-2-oxido-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1H-purishow more
    SMILES
    C1C2C(C(C(O2)N3C4=C(C(=O)NC(=N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=S)(O1)[O-].[Na+]
    InChIKey
    JERAACMSJYSCBY-UHFFFAOYSA-M
    InChI
    1S/C16H15ClN5O6PS2.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(27-14)5-26-29(25,30)28-11;/h1-4,8,10-11,14,23H,5H2,(H,25show more
    Synonyms
    8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
  5. Rp-8-Br-cGMPS
    CAS: 150418-07-8 PubChem CID: 3035839 Formula: C10H11BrN5O6PS Molecular Weight: 440.17
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: R275791
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    Technical Identifiers
    IUPAC Name
    (2R,5R)-2-(2-amino-8-bromopurin-9-yl)-5-(dihydroxyphosphinothioyloxymethyl)-2,5-dihydrofuran-3,4-diol
    SMILES
    C1=C2C(=NC(=N1)N)N(C(=N2)Br)C3C(=C(C(O3)COP(=S)(O)O)O)O
    InChIKey
    NKBRWLDMUXONRI-SPGJFGJESA-N
    InChI
    1S/C10H11BrN5O6PS/c11-9-14-3-1-13-10(12)15-7(3)16(9)8-6(18)5(17)4(22-8)2-21-23(19,20)24/h1,4,8,17-18H,2H2,(H2,12,13,15)(H2,19,20,24)/t4-,8-/m1/s1
    Synonyms
    DTXSID20933942 | Rp-8-BrcGMPS | (R)-8-Bromoguanosine cyclic 3',5'-(hydrogen phosphorothioate) | O-{[5-(8-Bromo-2-imin...
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

How is the PKG listing put together?
It draws on reported PKG annotations within Stem Cell/Wnt and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a PKG modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the PKG entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for PKG compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For PKG work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the PKG compound I need is not listed?
Search by CAS number or SMILES first, since analogs of PKG compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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