Porcupine

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  1. IWP L6
    CAS: 1427782-89-5 Formula: C25H20N4O2S2 Molecular Weight: 472.58
    ● In Stock — US warehouse, ships to EU* Item #: I288756
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    Technical Identifiers
    IUPAC Name
    2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide
    SMILES
    C1CSC2=C1N=C(N(C2=O)C3=CC=CC=C3)SCC(=O)NC4=NC=C(C=C4)C5=CC=CC=C5
    InChIKey
    QESQGTFWEQMCMH-UHFFFAOYSA-N
    InChI
    1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,2show more
    Synonyms
    N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide | 2-[(4-oxo-...
  2. IWP-2
    CAS: 686770-61-6 Formula: C22H18N4O2S3 Molecular Weight: 466.6
    ● In Stock — US warehouse, ships to EU* Item #: I126927
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    IUPAC Name
    N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
    SMILES
    CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
    InChIKey
    WRKPZSMRWPJJDH-UHFFFAOYSA-N
    InChI
    1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27show more
    Synonyms
    BDBM50428028 | HMS3652J22 | IWP-2, >=98% (HPLC) | CID 2155128 | EX-A2264 | N -(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7...
  3. LGK 974, Probable protein-cysteine N-palmitoyltransferase porcupine inhibitor
    CAS: 1243244-14-5 Formula: C23H20N6O Molecular Weight: 396.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: L340659
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    IUPAC Name
    2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
    SMILES
    CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4
    InChIKey
    XXYGTCZJJLTAGH-UHFFFAOYSA-N
    InChI
    1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
    Synonyms
    HY-17545 | LGK 974 | BBL102809 | NVP-LGK974 | NCGC00347950-02 | SCHEMBL1723611 | AKOS025211913 | SW211728-2 | BCP0849...
  4. ETC-159, Inhibitor of porcupine O-acyltransferase
    CAS: 1638250-96-0 Formula: C19H17N7O3 Molecular Weight: 391.38
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: E413550
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    IUPAC Name
    2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
    SMILES
    CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
    InChIKey
    QTRXIFVSTWXRJJ-UHFFFAOYSA-N
    InChI
    1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
    Synonyms
    NSC809251 | NSC-809251 | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetam...
  5. ETC-159, Inhibitor of porcupine O-acyltransferase
    CAS: 1638250-96-0 Formula: C19H17N7O3 Molecular Weight: 391.38
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: E422019
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    Technical Identifiers
    IUPAC Name
    2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
    SMILES
    CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
    InChIKey
    QTRXIFVSTWXRJJ-UHFFFAOYSA-N
    InChI
    1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
    Synonyms
    NSC809251 | NSC-809251 | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetam...
  6. GNF-6231, Inhibitor of porcupine O-acyltransferase
    CAS: 1243245-18-2 Formula: C24H25FN6O2 Molecular Weight: 448.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: G421042
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    IUPAC Name
    N-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]-2-[6-(2-fluoropyridin-4-yl)-5-methylpyridin-3-yl]acetamide
    SMILES
    CC1=CC(=CN=C1C2=CC(=NC=C2)F)CC(=O)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)C
    InChIKey
    AXXNRMISICMFNS-UHFFFAOYSA-N
    InChI
    1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(show more
    Synonyms
    [2,​4'-​Bipyridine]​-​5-​acetamide,N-​[5-​(4-​acetyl-​1-​piperazinyl)​-​2-​pyridinyl]​-​2'-​fluoro-​3-​methyl-
  7. GNF-6231, Inhibitor of porcupine O-acyltransferase
    CAS: 1243245-18-2 Formula: C24H25FN6O2 Molecular Weight: 448.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: G414093
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    Technical Identifiers
    IUPAC Name
    N-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]-2-[6-(2-fluoropyridin-4-yl)-5-methylpyridin-3-yl]acetamide
    SMILES
    CC1=CC(=CN=C1C2=CC(=NC=C2)F)CC(=O)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)C
    InChIKey
    AXXNRMISICMFNS-UHFFFAOYSA-N
    InChI
    1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(show more
    Synonyms
    N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl[2,4'-bipyridine]-5-acetamide
  8. IWP L6
    CAS: 1427782-89-5 Formula: C25H20N4O2S2 Molecular Weight: 472.58
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: I421578
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    Technical Identifiers
    IUPAC Name
    2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide
    SMILES
    C1CSC2=C1N=C(N(C2=O)C3=CC=CC=C3)SCC(=O)NC4=NC=C(C=C4)C5=CC=CC=C5
    InChIKey
    QESQGTFWEQMCMH-UHFFFAOYSA-N
    InChI
    1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,2show more
    Synonyms
    N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
  9. IWP-2
    CAS: 686770-61-6 Formula: C22H18N4O2S3 Molecular Weight: 466.6
    2mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: I425479
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    Technical Identifiers
    IUPAC Name
    N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
    SMILES
    CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
    InChIKey
    WRKPZSMRWPJJDH-UHFFFAOYSA-N
    InChI
    1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27show more
    Synonyms
    BDBM50428028 | HMS3652J22 | IWP-2, >=98% (HPLC) | CID 2155128 | EX-A2264 | N -(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7...
  10. IWP-O1
    CAS: 2074607-48-8 Formula: C26H20N6O Molecular Weight: 432.48
    ● In Stock — US warehouse, ships to EU* Item #: I414094
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    Technical Identifiers
    IUPAC Name
    N-(5-phenylpyridin-2-yl)-2-(5-phenyl-4-pyridin-4-yltriazol-1-yl)acetamide
    SMILES
    C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5
    InChIKey
    GYYDQHBKIHQHEB-UHFFFAOYSA-N
    InChI
    1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)
    Synonyms
    1H-​1,​2,​3-​Triazole-​1-​acetamide,5-​phenyl-​N-​(5-​phenyl-​2-​pyridinyl)​-​4-​(4-​pyridinyl)​- | 5-Phenyl-N-(5-phe...
  11. IWP-O1
    CAS: 2074607-48-8 Formula: C26H20N6O Molecular Weight: 432.48
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: I422517
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    Technical Identifiers
    IUPAC Name
    N-(5-phenylpyridin-2-yl)-2-(5-phenyl-4-pyridin-4-yltriazol-1-yl)acetamide
    SMILES
    C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5
    InChIKey
    GYYDQHBKIHQHEB-UHFFFAOYSA-N
    InChI
    1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)
    Synonyms
    1H-​1,​2,​3-​Triazole-​1-​acetamide,5-​phenyl-​N-​(5-​phenyl-​2-​pyridinyl)​-​4-​(4-​pyridinyl)​-
  12. Porcn-IN-1
    CAS: 2036044-77-4 PubChem CID: 132578555 Formula: C25H19FN4O Molecular Weight: 410.44
    ● In Stock — US warehouse, ships to EU* Item #: P412192
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    Technical Identifiers
    IUPAC Name
    N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
    SMILES
    CC1=NC=CC(=C1)C2=C(C=C(C=N2)CNC(=O)C3=CC4=C(C=C3)C5=CC=CC=C5N4)F
    InChIKey
    GOMFFTZBKYVUOE-UHFFFAOYSA-N
    InChI
    1S/C25H19FN4O/c1-15-10-17(8-9-27-15)24-21(26)11-16(13-28-24)14-29-25(31)18-6-7-20-19-4-2-3-5-22(19)30-23(20)12-18/h2-13,30H,14H2,1H3,(H,29,31)
    Synonyms
    MDK-4774 | MDK-4774 free base
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Frequently Asked Questions

What can I find under Porcupine?
This listing collects compounds associated with Porcupine within our Stem Cell/Wnt area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for Porcupine?
Consider the reported potency of each Porcupine compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for Porcupine compounds?
Each Porcupine product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Porcupine compounds by activity or structure?
Yes. Filter the Porcupine listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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