RAR/RXR

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  1. Retinoic acid
    CAS: 302-79-4 EC Number: 206-129-0 Formula: C20H28O2 Molecular Weight: 300.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: R106320
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    IUPAC Name
    (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    SMILES
    CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
    InChIKey
    SHGAZHPCJJPHSC-YCNIQYBTSA-N
    InChI
    1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
    Synonyms
    (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF...
  2. Ro 41-5253, Antagonist of Retinoic acid receptor-α
    CAS: 144092-31-9 PubChem CID: 5312120 Formula: C28H36O5S Molecular Weight: 484.7
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Made to order · 8–12 wks Item #: R275860
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    IUPAC Name
    4-[(E)-2-(7-heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoic acid
    SMILES
    CCCCCCCOC1=CC2=C(C=C1C(=CC3=CC=C(C=C3)C(=O)O)C)C(CCS2(=O)=O)(C)C
    InChIKey
    JEIWQRITHXYGIF-LVZFUZTISA-N
    InChI
    1S/C28H36O5S/c1-5-6-7-8-9-15-33-25-19-26-24(28(3,4)14-16-34(26,31)32)18-23(25)20(2)17-21-10-12-22(13-11-21)27(29)30/h10-13,17-19H,5-9,14-16H2,1-4H3,(Hshow more
    Synonyms
    NCGC00485412-01 | Ro 415253 | Ro 41-5253 | SCHEMBL4183654 | MS-29010 | 4-((E)-2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3...
  3. Magnolol
    CAS: 528-43-8 EC Number: 610-903-7 Formula: C18H18O2 Molecular Weight: 266.33
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: M111378
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    IUPAC Name
    2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
    SMILES
    C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
    InChIKey
    VVOAZFWZEDHOOU-UHFFFAOYSA-N
    InChI
    1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
    Synonyms
    NCGC00161609-01 | Ethylene glycol butyl ether | s2321 | STK801955 | Methyl n-dodecanoate | Magnolol,(S) | 5,5'-DI-2-P...
  4. SR 11237, Agonist of Retinoid X receptor-α
    CAS: 146670-40-8 PubChem CID: 127019 Formula: C24H28O4 Molecular Weight: 380.48
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: S287354
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    IUPAC Name
    4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid
    SMILES
    CC1(CCC(C2=C1C=CC(=C2)C3(OCCO3)C4=CC=C(C=C4)C(=O)O)(C)C)C
    InChIKey
    ZZUKALQMHNSWTK-UHFFFAOYSA-N
    InChI
    1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
    Synonyms
    Q27088859 | BMS 188649; BMS 649; SR 11237 | HMS3677L18 | HY-107413 | SR11237, >=98% (HPLC) | 4-(2-(5,5,8,8-Tetramethy...
  5. MM 11253, Antagonist of Retinoic acid receptor-γ
    CAS: 345952-44-5 Formula: C28H30O2S2 Molecular Weight: 462.66
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: M275863
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    IUPAC Name
    6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid
    SMILES
    CC1(CCC(C2=C1C=CC(=C2)C3(SCCS3)C4=CC5=C(C=C4)C=C(C=C5)C(=O)O)(C)C)C
    InChIKey
    DPVGXUNWCVEIGT-UHFFFAOYSA-N
    InChI
    1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,show more
    Synonyms
    MM11253 | MM-11253 | J-019670 | MM11253, >=98% (HPLC) | BDBM50157727 | 6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthale...
  6. CD437, Agonist of Retinoic acid receptor-γ
    CAS: 125316-60-1 EC Number: 692-455-2 Formula: C27H26O3 Molecular Weight: 398.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: O133218
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    IUPAC Name
    6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid
    SMILES
    C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O
    InChIKey
    LDGIHZJOIQSHPB-UHFFFAOYSA-N
    InChI
    1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29show more
    Synonyms
    CD 437 | 6-[3-(1-adamantyl)-4-hydroxy-phenyl]naphthalene-2-carboxylic acid | 6-[3-(1-adamantyl)-4-hydroxyphenyl]napht...
  7. 9-cis-Retinoic Acid, Agonist of Retinoic acid receptor-α;Agonist of Retinoic acid receptor-β;Agonist of Retinoic acid receptor-γ;Agonist of Retinoid X receptor-α;Agonist of Retinoid X receptor-β;Agonist of Retinoid X receptor-γ
    CAS: 5300-03-8 EC Number: 610-929-9 Formula: C20H28O2 Molecular Weight: 300.435
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: C305934
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    IUPAC Name
    (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    SMILES
    CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
    InChIKey
    SHGAZHPCJJPHSC-ZVCIMWCZSA-N
    InChI
    1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
    Synonyms
    Isotretinoin Retinoic acid | Toctino | (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetr...
  8. UVI 3003, Antagonist of Retinoid X receptor-α;Antagonist of Retinoid X receptor-β
    CAS: 847239-17-2 PubChem CID: 44566108 Formula: C28H36O4 Molecular Weight: 436.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: U287111
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    IUPAC Name
    (E)-3-[4-hydroxy-3-(5,5,8,8-tetramethyl-3-pentoxy-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid
    SMILES
    CCCCCOC1=CC2=C(C=C1C3=C(C=CC(=C3)C=CC(=O)O)O)C(CCC2(C)C)(C)C
    InChIKey
    APJSHECCIRQQDV-ZRDIBKRKSA-N
    InChI
    1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,3show more
    Synonyms
    BS-17614 | AKOS024457539 | SCHEMBL19119381 | GTPL2816 | compound 10e [PMID: 19408900] | (2E)-3-{4-hydroxy-3-[5,5,8,8-...
  9. PA 452, Antagonist of Retinoid X receptor-α
    CAS: 457657-34-0 PubChem CID: 9803242 Formula: C26H37N3O3 Molecular Weight: 439.59
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: P288123
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    IUPAC Name
    2-[(3-hexoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-methylamino]pyrimidine-5-carboxylic acid
    SMILES
    CCCCCCOC1=C(C=C2C(=C1)C(CCC2(C)C)(C)C)N(C)C3=NC=C(C=N3)C(=O)O
    InChIKey
    JJUUTJCZMGZJDZ-UHFFFAOYSA-N
    InChI
    1S/C26H37N3O3/c1-7-8-9-10-13-32-22-15-20-19(25(2,3)11-12-26(20,4)5)14-21(22)29(6)24-27-16-18(17-28-24)23(30)31/h14-17H,7-13H2,1-6H3,(H,30,31)
    Synonyms
    2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid
  10. Adapalene, Agonist of Retinoic acid receptor-αAgonist of Retinoic acid receptor-βAgonist of Retinoic acid receptor-γ
    CAS: 106685-40-9 EC Number: 620-513-9 Formula: C28H28O3 Molecular Weight: 412.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: A120006
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    IUPAC Name
    6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
    SMILES
    COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
    InChIKey
    LZCDAPDGXCYOEH-UHFFFAOYSA-N
    InChI
    1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,show more
    Synonyms
    6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid | Adapaleno [INN-Spanish] | CD271 | C...
  11. Acitretin, Retinoid receptor agonist
    CAS: 55079-83-9 EC Number: 259-474-4 Formula: C21H26O3 Molecular Weight: 326.43
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: A102064
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    IUPAC Name
    (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
    SMILES
    CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
    InChIKey
    IHUNBGSDBOWDMA-AQFIFDHZSA-N
    InChI
    1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
    Synonyms
    Acitretin | ACITRETIN [HSDB] | (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraen...
  12. 9-cis-Retinoic Acid, Retinoid receptor agonist
    CAS: 5300-03-8 EC Number: 610-929-9 Formula: C20H28O2 Molecular Weight: 300.435
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: C134191
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    Technical Identifiers
    IUPAC Name
    (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    SMILES
    CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
    InChIKey
    SHGAZHPCJJPHSC-ZVCIMWCZSA-N
    InChI
    1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
    Synonyms
    Isotretinoin Retinoic acid | Toctino | (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetr...
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Frequently Asked Questions

How is the RAR/RXR listing put together?
It draws on reported RAR/RXR annotations within Metabolic Enzyme/Protease and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a RAR/RXR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the RAR/RXR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for RAR/RXR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For RAR/RXR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the RAR/RXR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of RAR/RXR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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