SGK

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  1. GSK 650394, Inhibitor of serum/glucocorticoid regulated kinase 1;Inhibitor of serum/glucocorticoid regulated kinase 2
    CAS: 890842-28-1 Formula: C25H22N2O2 Molecular Weight: 382.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: G287167
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    Technical Identifiers
    IUPAC Name
    2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
    SMILES
    C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O
    InChIKey
    WVSBGSNVCDAMCF-UHFFFAOYSA-N
    InChI
    1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,2show more
    Synonyms
    MLS006010262 | OXAPROZIN [USP-RS] | SMR004701335 | Q27077915 | AC-32637 | AKOS024457693 | HMS3677P22 | NCGC00250410-1...
  2. CKI-7 dihydrochloride
    CAS: 1177141-67-1 EC Number: 689-633-7 PubChem CID: 16078955 Formula: C11H12ClN3O2S · 2HCl Molecular Weight: 358.67
    Solid ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: N134264
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    IUPAC Name
    N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide;dihydrochloride
    SMILES
    C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl.Cl.Cl
    InChIKey
    JUAVTXYOCISSSL-UHFFFAOYSA-N
    InChI
    1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
    Synonyms
    N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide;dihydrochloride | N-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONA...
  3. EMD638683, Inhibitor of serum/glucocorticoid regulated kinase 1
    CAS: 1181770-72-8 Formula: C18H18F2N2O4 Molecular Weight: 364.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: E127679
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    IUPAC Name
    N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
    SMILES
    CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O
    InChIKey
    SSNAPUUWBPZGOY-UHFFFAOYSA-N
    InChI
    1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)
    Synonyms
    A925647 | Z3247511913 | BCP29409 | EMD 638683; EMD-638683 | C18H18F2N2O4 | HY-15193 | 1181770-72-8 | 2-(3,5-DIFLUOROP...
  4. EMD638683, Inhibitor of serum/glucocorticoid regulated kinase 1
    CAS: 1181770-72-8 Formula: C18H18F2N2O4 Molecular Weight: 364.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: E420805
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    Technical Identifiers
    IUPAC Name
    N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
    SMILES
    CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O
    InChIKey
    SSNAPUUWBPZGOY-UHFFFAOYSA-N
    InChI
    1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)
    Synonyms
    A925647 | Z3247511913 | BCP29409 | EMD 638683; EMD-638683 | C18H18F2N2O4 | HY-15193 | 1181770-72-8 | 2-(3,5-DIFLUOROP...
  5. GSK 650394, Inhibitor of serum/glucocorticoid regulated kinase 1;Inhibitor of serum/glucocorticoid regulated kinase 2
    CAS: 890842-28-1 Formula: C25H22N2O2 Molecular Weight: 382.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: G426702
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    Technical Identifiers
    IUPAC Name
    2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
    SMILES
    C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O
    InChIKey
    WVSBGSNVCDAMCF-UHFFFAOYSA-N
    InChI
    1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,2show more
    Synonyms
    MLS006010262 | OXAPROZIN [USP-RS] | SMR004701335 | Q27077915 | AC-32637 | AKOS024457693 | HMS3677P22 | NCGC00250410-1...
  6. PROTAC SGK3 degrader-1
    CAS: 2381320-35-8 PubChem CID: 139035049 Formula: C57H73FN10O11S2 Molecular Weight: 1157.38
    ● In Stock — US warehouse, ships to EU* Item #: P414454
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    Technical Identifiers
    IUPAC Name
    (2S,4R)-1-[(2S)-2-[[2-[2-[2-[6-[(2R)-2-[[6-[4-[(2-fluoro-5-methylphenyl)sulfonylamino]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxymethyl]morpholin-4-yshow more
    SMILES
    CC1=CC(=C(C=C1)F)S(=O)(=O)NC2=CC=C(C=C2)C3=NC4=C(C=NN4)C(=N3)OCC5CN(CCO5)CCCCCCOCCOCCOCC(=O)NC(C(=O)N6CC(CC6C(=O)NCC7=CC=C(C=C7)C8=C(N=CS8)C)O)C(C)(C)show more
    InChIKey
    RTFQFPZKDYMMMJ-RIAKQDHQSA-N
    InChI
    1S/C57H73FN10O11S2/c1-37-10-19-46(58)48(28-37)81(73,74)66-42-17-15-41(16-18-42)52-63-53-45(31-61-65-53)55(64-52)79-34-44-33-67(21-23-78-44)20-8-6-7-9-show more
    Synonyms
    SGK3-PROTAC1
  7. SGK1-IN-1
    CAS: 1279829-87-6 PubChem CID: 71506845 Formula: C17H12ClFN6O2S Molecular Weight: 418.83
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: S647642
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    Technical Identifiers
    IUPAC Name
    N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-fluorobenzenesulfonamide
    SMILES
    C1=CC(=CC=C1C2=NC3=NNC(=C3N=C2)N)NS(=O)(=O)C4=C(C=CC(=C4)Cl)F
    InChIKey
    DDKHTWASHUKHLD-UHFFFAOYSA-N
    InChI
    1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)
    Synonyms
    Sgk1-in-1
  8. HaloPROTAC-E
    CAS: 2365478-58-4 PubChem CID: 154723985 Formula: C39H56ClN5O8S Molecular Weight: 790.4
    ◐ .Made to order · 8–12 wks Item #: H651187
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    Technical Identifiers
    IUPAC Name
    (2S,4R)-N-[[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)aminoshow more
    SMILES
    CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O)OCCOCCOCCOCCCCCCCl
    InChIKey
    NJCGXLMTZGCSRS-JSWXEYCZSA-N
    InChI
    1S/C39H56ClN5O8S/c1-27-33(54-26-43-27)28-9-10-29(32(21-28)53-20-19-52-18-17-51-16-15-50-14-8-6-5-7-13-40)23-42-35(47)31-22-30(46)24-45(31)36(48)34(38(show more
  9. SGK1-IN-2
    CAS: 1426214-64-3 PubChem CID: 71537261 Formula: C17H12Cl2N6O2S Molecular Weight: 435.29
    ◐ .Made to order · 8–12 wks Item #: S646550
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    Technical Identifiers
    IUPAC Name
    N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-dichlorobenzenesulfonamide
    SMILES
    C1=CC(=CC=C1C2=NC3=NNC(=C3N=C2)N)NS(=O)(=O)C4=C(C=CC(=C4)Cl)Cl
    InChIKey
    RTERCHJCWXQPSS-UHFFFAOYSA-N
    InChI
    1S/C17H12Cl2N6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)
  10. EMD638683 S-Form
    CAS: 1184940-46-2 Formula: C18H18F2N2O4 Molecular Weight: 364.34
    ◐ .Made to order · 8–12 wks Item #: E646668
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    Technical Identifiers
    IUPAC Name
    N'-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
    SMILES
    CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O
    InChIKey
    SSNAPUUWBPZGOY-INIZCTEOSA-N
    InChI
    1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)/t16-/m0/s1
    Synonyms
    1184940-46-2 | A921421 | N'-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide | ...
  11. EMD638683 R-Form
    CAS: 1184940-47-3 Formula: C18H18F2N2O4 Molecular Weight: 364.34
    ◐ .Made to order · 8–12 wks Item #: E647755
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    Technical Identifiers
    IUPAC Name
    N'-[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
    SMILES
    CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O
    InChIKey
    SSNAPUUWBPZGOY-MRXNPFEDSA-N
    InChI
    1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)/t16-/m1/s1
    Synonyms
    A926968 | EMD638683 (R-Form) | EMD638683 R-Form | DTXSID40735349 | AKOS030526292 | 1184940-47-3 | (R)-N'-(2-(3,5-Difl...
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Frequently Asked Questions

Which compounds are listed for SGK?
Compounds associated with SGK are grouped here under the Metabolic Enzyme/Protease classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does SGK sit within Metabolic Enzyme/Protease?
SGK is one target listing within the Metabolic Enzyme/Protease classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from SGK?
For compounds listed under SGK, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for SGK?
Browse the parent Metabolic Enzyme/Protease listing to reach targets neighbouring SGK, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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