TAM Receptor

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  1. Gilteritinib, Tyrosine-protein kinase receptor UFO inhibitor
    CAS: 1254053-43-4 EC Number: 107-777-6 Formula: C29H44N8O3 Molecular Weight: 552.7115
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: G172979
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    IUPAC Name
    6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
    SMILES
    CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5
    InChIKey
    GYQYAJJFPNQOOW-UHFFFAOYSA-N
    InChI
    1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-2show more
    Synonyms
    GILTERITINIB [WHO-DD] | Gilteritinib HCl | NCGC00481652-01 | AS-35199 | GILTERITINIB [MI] | 1,4-Oxadiazole, 2-(o-hydr...
  2. CEP-40783
    CAS: 1437321-24-8 Formula: C31H26F2N4O6 Molecular Weight: 588.6
    ● In Stock — US warehouse, ships to EU* Item #: C174233
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    IUPAC Name
    N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
    SMILES
    CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F
    InChIKey
    FKCWHHYUMFGOPY-UHFFFAOYSA-N
    InChI
    1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)2show more
    Synonyms
    AS-35141 | N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-te...
  3. UNC 2881
    CAS: 1493764-08-1 PubChem CID: 71721525 Formula: C25H33N7O2 Molecular Weight: 463.58
    ● In Stock — US warehouse, ships to EU* Item #: U288499
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    IUPAC Name
    2-(butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamide
    SMILES
    CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C(=O)NCC3=CC=C(C=C3)N4C=CN=C4
    InChIKey
    NPVXOWLPOFYACO-UHFFFAOYSA-N
    InChI
    1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33Hshow more
    Synonyms
    UNC2881 | 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarb...
  4. BMS-777607, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of macrophage stimulating 1 receptor;Inhibitor of MER proto-oncogene; tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of TYRO3 protein tyrosine kinase
    CAS: 1025720-94-8 EC Number: 110-725-5 Formula: C25H19ClF2N4O4 Molecular Weight: 512.89
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: B129782
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    IUPAC Name
    N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
    SMILES
    CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F
    InChIKey
    VNBRGSXVFBYQNN-UHFFFAOYSA-N
    InChI
    1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,2show more
    Synonyms
    FT-0701277 | SCHEMBL2588311 | 3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethox...
  5. R428 (BGB324), Tyrosine-protein kinase receptor UFO inhibitor
    CAS: 1037624-75-1 EC Number: 894-430-3 PubChem CID: 46215462 Formula: C30H34N8 Molecular Weight: 506.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: R127995
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    IUPAC Name
    1-(3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4show more
    SMILES
    C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
    InChIKey
    KXMZDGSRSGHMMK-VWLOTQADSA-N
    InChI
    1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10show more
    Synonyms
    BGB324; BGB-324; BGB 324; R 428; R-428; Bemcentinib | NSC824183 | NSC-824183 | BCP21180 | R428 | R-428 | GTPL10478 | ...
  6. 2-D08
    CAS: 144707-18-6 Formula: C15H10O5 Molecular Weight: 270.24
    ● In Stock — US warehouse, ships to EU* Item #: D167318
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    IUPAC Name
    2-(2,3,4-trihydroxyphenyl)chromen-4-one
    SMILES
    C1=CC=C2C(=C1)C(=O)C=C(O2)C3=C(C(=C(C=C3)O)O)O
    InChIKey
    JJAXTFSPCLZPIW-UHFFFAOYSA-N
    InChI
    1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H
    Synonyms
    PD044048 | HY-114166 | SCHEMBL1772778 | D82631 | 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one | BCP18314 | AMY31051 | ...
  7. 2-D08
    CAS: 144707-18-6 EC Number: 808-530-1 Formula: C15H10O5 Molecular Weight: 270.24
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: D421647
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    Technical Identifiers
    IUPAC Name
    2-(2,3,4-trihydroxyphenyl)chromen-4-one
    SMILES
    C1=CC=C2C(=C1)C(=O)C=C(O2)C3=C(C(=C(C=C3)O)O)O
    InChIKey
    JJAXTFSPCLZPIW-UHFFFAOYSA-N
    InChI
    1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H
    Synonyms
    PD044048 | HY-114166 | SCHEMBL1772778 | D82631 | 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one | BCP18314 | AMY31051 | ...
  8. CEP-40783
    CAS: 1437321-24-8 Formula: C31H26F2N4O6 Molecular Weight: 588.6
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C421610
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    Technical Identifiers
    IUPAC Name
    N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
    SMILES
    CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F
    InChIKey
    FKCWHHYUMFGOPY-UHFFFAOYSA-N
    InChI
    1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)2show more
    Synonyms
    AS-35141 | N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-te...
  9. Cabozantinib (XL184, BMS-907351), Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of ret proto-oncogene
    CAS: 849217-68-1 EC Number: 692-846-8 Formula: C28H24FN3O5 Molecular Weight: 501.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C126195
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    IUPAC Name
    1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES
    COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
    InChIKey
    ONIQOQHATWINJY-UHFFFAOYSA-N
    InChI
    1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-1show more
    Synonyms
    BDBM50021574 | N-[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]-N inverted exclamation mark -(4-fluorophenyl)cyclopropan...
  10. Dubermatinib(TP-0903), Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of AXL receptor tyrosine kinase
    CAS: 1341200-45-0 Formula: C24H30ClN7O2S Molecular Weight: 516.06
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 2mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: D421290
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    IUPAC Name
    2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
    SMILES
    CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl
    InChIKey
    YUAALFPUEOYPNX-UHFFFAOYSA-N
    InChI
    1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3show more
    Synonyms
    2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide ...
  11. Dubermatinib(TP-0903), Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of AXL receptor tyrosine kinase
    CAS: 1341200-45-0 Formula: C24H30ClN7O2S Molecular Weight: 516.06
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: D413851
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    Technical Identifiers
    IUPAC Name
    2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
    SMILES
    CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl
    InChIKey
    YUAALFPUEOYPNX-UHFFFAOYSA-N
    InChI
    1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3show more
    Synonyms
    2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide ...
  12. Gilteritinib, Tyrosine-protein kinase receptor UFO inhibitor
    CAS: 1254053-43-4 EC Number: 107-777-6 Formula: C29H44N8O3 Molecular Weight: 552.7115
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: G421064
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    Technical Identifiers
    IUPAC Name
    6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
    SMILES
    CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5
    InChIKey
    GYQYAJJFPNQOOW-UHFFFAOYSA-N
    InChI
    1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-2show more
    Synonyms
    GILTERITINIB [WHO-DD] | Gilteritinib HCl | NCGC00481652-01 | AS-35199 | GILTERITINIB [MI] | 1,4-Oxadiazole, 2-(o-hydr...
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Frequently Asked Questions

How is the TAM Receptor listing put together?
It draws on reported TAM Receptor annotations within Protein Tyrosine Kinase/RTK and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a TAM Receptor modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the TAM Receptor entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for TAM Receptor compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For TAM Receptor work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the TAM Receptor compound I need is not listed?
Search by CAS number or SMILES first, since analogs of TAM Receptor compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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