TRP Channel

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  1. GSK-1016790A, Activator of TRPV4
    CAS: 942206-85-1 Formula: C28H32Cl2N4O6S2 Molecular Weight: 655.61
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: G275374
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    IUPAC Name
    N-[(2S)-1-[4-[(2S)-2-[(2,4-dichlorophenyl)sulfonylamino]-3-hydroxypropanoyl]piperazin-1-yl]-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
    SMILES
    CC(C)CC(C(=O)N1CCN(CC1)C(=O)C(CO)NS(=O)(=O)C2=C(C=C(C=C2)Cl)Cl)NC(=O)C3=CC4=CC=CC=C4S3
    InChIKey
    IVYQPSHHYIAUFO-VXKWHMMOSA-N
    InChI
    1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/hshow more
    Synonyms
    GSK101 | HY-19608 | GSK 1016790A | N-[(2S)-1-[4-[(2S)-2-[(2,4-dichlorophenyl)sulfonylamino]-3-hydroxypropanoyl]pipera...
  2. Linopirdine dihydrochloride
    CAS: 113168-57-3 PubChem CID: 14209557 Formula: C26H21N3O.2HCl Molecular Weight: 464.39
    ◐ .Made to order · 8–12 wks Item #: L274931
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    IUPAC Name
    1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one;dihydrochloride
    SMILES
    C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
    InChIKey
    ZEVVHCGTTNRYOY-UHFFFAOYSA-N
    InChI
    1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H
    Synonyms
    1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-onedihydrochloride
  3. GSK 2193874, Channel blocker of TRPV4
    CAS: 1336960-13-4 EC Number: 808-437-6 Formula: C37H38BrF3N4O Molecular Weight: 691.62
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: G287297
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    IUPAC Name
    7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
    SMILES
    C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7
    InChIKey
    UIVOZBSCHXCGPS-UHFFFAOYSA-N
    InChI
    1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36show more
    Synonyms
    GSK2193874 | GSK-2193874 | GTPL6465 | NCGC00370767-01 | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopr...
  4. GSK 1702934A, Activator of TRPC3;Activator of TRPC6
    CAS: 924377-85-5 Formula: C22H25N3O2S Molecular Weight: 395.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ◐ .Made to order · 8–12 wks Item #: G288131
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    IUPAC Name
    3-[1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one
    SMILES
    C1CCC2=C(CC1)SC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5NC4=O
    InChIKey
    AXWRAIIIBRLXBP-UHFFFAOYSA-N
    InChI
    1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27)
    Synonyms
    GSK1702934A | GSK-1702934A | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl...
  5. NADA (N-Arachidonyldopamine), Channel blocker of TRPM8;Channel blocker of TRPV1
    CAS: 199875-69-9 PubChem CID: 5282105 Formula: C28H41NO3 Molecular Weight: 439.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: N275117
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    IUPAC Name
    (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide
    SMILES
    CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCC1=CC(=C(C=C1)O)O
    InChIKey
    MVVPIAAVGAWJNQ-DOFZRALJSA-N
    InChI
    1S/C28H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-28(32)29-23-22-25-20-21-26(30)27(31)24-25/h6-7,9-10,12-13,15-16,20-21,24,30-31H,2-5,8,11show more
    Synonyms
    5,8,11,14-EICOSATETRAENAMIDE, N-(2-(3,4-DIHYDROXYPHENYL)ETHYL)-, (5Z,8Z,11Z,14Z)- | SR-01000946639 | Q3869319 | AA-DA...
  6. PF 05105679, Channel blocker of TRPM8
    CAS: 1398583-31-7 EC Number: 809-223-5 PubChem CID: 60195662 Formula: C26H21FN2O3 Molecular Weight: 428.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: P287705
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    IUPAC Name
    3-[[[(1R)-1-(4-fluorophenyl)ethyl]-(quinoline-3-carbonyl)amino]methyl]benzoic acid
    SMILES
    CC(C1=CC=C(C=C1)F)N(CC2=CC(=CC=C2)C(=O)O)C(=O)C3=CC4=CC=CC=C4N=C3
    InChIKey
    BXNMZRPTQFVRFA-QGZVFWFLSA-N
    InChI
    1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/mshow more
    Synonyms
    PF 05105679 | (R)-3-((N-(1-(4-fluorophenyl)ethyl)quinoline-3-carboxamido)methyl)benzoic acid | SCHEMBL12487950 | PF05...
  7. 1-Stearoyl-2-arachidonoyl-sn-glycerol, Activator of TRPC6
    CAS: 65914-84-3 PubChem CID: 6438587 Formula: C41H72O5 Molecular Weight: 645.01
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95% 25mg/ml in methyl acetate
    ◐ .Made to order · 8–12 wks Item #: S347974
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    IUPAC Name
    [(2S)-1-hydroxy-3-octadecanoyloxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
    SMILES
    CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
    InChIKey
    NSXLMTYRMFVYNT-IUJDHQGTSA-N
    InChI
    1S/C41H72O5/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(44)46-39(37-42)38-45-40(43)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,1show more
    Synonyms
    DG(18:0/20:4(omega-6)/0:0) | DG(18:0/20:4omega6) | (2S)-1-hydroxy-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icos...
  8. SAR7334 hydrochloride
    CAS: 1333207-63-8 PubChem CID: 78357800 Formula: C21H24Cl3N3O Molecular Weight: 440.79
    ◐ .Made to order · 8–12 wks Item #: S286732
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    IUPAC Name
    4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile;dihydrochloride
    SMILES
    C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N.Cl.Cl
    InChIKey
    LFMYIKNZNTZSJX-IQJQELQDSA-N
    InChI
    1S/C21H22ClN3O.2ClH/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25;;/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2;2*1H/show more
    Synonyms
    4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
  9. Methyl 3,5-dimethoxy-4-hydroxybenzoate
    CAS: 884-35-5 EC Number: 618-163-7 Formula: C10H12O5 Molecular Weight: 212.2
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: M334230
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    IUPAC Name
    methyl 4-hydroxy-3,5-dimethoxybenzoate
    SMILES
    COC1=CC(=CC(=C1O)OC)C(=O)OC
    InChIKey
    ZMXJAEGJWHJMGX-UHFFFAOYSA-N
    InChI
    1S/C10H12O5/c1-13-7-4-6(10(12)15-3)5-8(14-2)9(7)11/h4-5,11H,1-3H3
    Synonyms
    M2806 | MFCD00017199 | Syringic acid monomethyl ester | UNII-W5A196MP8A | Fenaluz Turquoise G | SBB016976 | SY032894 ...
  10. cis-Capsaicin, Vanilloid receptor agonist
    CAS: 25775-90-0 EC Number: 636-760-0 Formula: C18H27NO3 Molecular Weight: 305.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: C346860
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    IUPAC Name
    (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
    SMILES
    CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
    InChIKey
    YKPUWZUDDOIDPM-VURMDHGXSA-N
    InChI
    1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6-
    Synonyms
    AC-31789 | HMS2051O07 | CHEBI:135952 | MLS000758306 | ZUCAPSAICIN [INN] | NCGC00017337-01 | (6Z)-N-[(4-hydroxy-3-meth...
  11. SB 452533, Channel blocker of TRPV1
    CAS: 459429-39-1 PubChem CID: 9842609 Formula: C18H22BrN3O Molecular Weight: 376.29
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: S288655
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    IUPAC Name
    1-(2-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea
    SMILES
    CCN(CCNC(=O)NC1=CC=CC=C1Br)C2=CC=CC(=C2)C
    InChIKey
    IFJYEGJUQIBBQV-UHFFFAOYSA-N
    InChI
    1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
    Synonyms
    n-(2-bromophenyl)-n'-[2-[ethyl(3-methylphenyl)amino]ethyl]urea | N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]...
  12. SB-366791, Channel blocker of TRPV1
    CAS: 472981-92-3 PubChem CID: 667594 Formula: C16H14ClNO2 Molecular Weight: 287.74
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S275140
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    IUPAC Name
    (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
    SMILES
    COC1=CC=CC(=C1)NC(=O)C=CC2=CC=C(C=C2)Cl
    InChIKey
    RYAMDQKWNKKFHD-JXMROGBWSA-N
    InChI
    1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
    Synonyms
    SR-01000597592-1 | 4'-CHLORO-3-METHOXYCINNAMANILIDE | 4-CHLORO-3-METHOXYCINNAMANILIDE | UNII-E8EY4M2N4H | SR-01000597...
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Frequently Asked Questions

How is the TRP Channel listing put together?
It draws on reported TRP Channel annotations within Neuronal Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a TRP Channel modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the TRP Channel entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for TRP Channel compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For TRP Channel work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the TRP Channel compound I need is not listed?
Search by CAS number or SMILES first, since analogs of TRP Channel compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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