Tryptophan Hydroxylase

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  1. Telotristat, Tryptophan 5-hydroxylase inhibitor
    CAS: 1033805-22-9 EC Number: 811-753-7 Formula: C27H26ClF3N6O3 Molecular Weight: 574.98
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ◐ .Made to order · 8–12 wks Item #: T171759
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    IUPAC Name
    ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate
    SMILES
    CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N
    InChIKey
    MDSQOJYHHZBZKA-GBXCKJPGSA-N
    InChI
    1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13show more
    Synonyms
    GTPL9490 | 1033805-22-9 | BDBM445704 | LX-1606 Hippurate | BCP9000866 | J-524318 | AS-35061 | LX1032 | LX-1032 | D099...
  2. 6-Fluoro-DL-tryptophan, Inhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2
    CAS: 7730-20-3 EC Number: 231-788-6 Formula: C11H11FN2O2 Molecular Weight: 222.22
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: F343329
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    IUPAC Name
    2-amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid
    SMILES
    C1=CC2=C(C=C1F)NC=C2CC(C(=O)O)N
    InChIKey
    YMEXGEAJNZRQEH-UHFFFAOYSA-N
    InChI
    1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)
    Synonyms
    (+/-)-6-FLUOROTRYPTOPHAN | dl-6-Fluorotryptophan | F-6880 | YMEXGEAJNZRQEH-UHFFFAOYSA-N | CHEBI:182183 | NSC9364 | NS...
  3. LX-1031
    CAS: 945976-76-1 PubChem CID: 23633604 Formula: C28H25F3N4O4 Molecular Weight: 538.52
    ● In Stock — US warehouse, ships to EU* Item #: L127156
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    IUPAC Name
    (2S)-2-amino-3-[4-[2-amino-6-[(1R)-2,2,2-trifluoro-1-[4-(3-methoxyphenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid
    SMILES
    COC1=CC=CC(=C1)C2=CC=C(C=C2)C(C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)CC(C(=O)O)N)N
    InChIKey
    XNMUICFMGGQSMZ-WIOPSUGQSA-N
    InChI
    1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,2show more
    Synonyms
    BDBM445705 | (S)-2-Amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxy-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-y...
  4. LX1606, Tryptophan 5-hydroxylase inhibitor
    CAS: 1137608-69-5 PubChem CID: 25253377 Formula: C36H35ClF3N7O6 Molecular Weight: 754.17
    ● In Stock — US warehouse, ships to EU* Item #: L126442
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    IUPAC Name
    2-benzamidoacetic acid;ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyshow more
    SMILES
    CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N.C1=CC=C(C=C1)C(=O)NCC(=O)O
    InChIKey
    XSFPZBUIBYMVEA-CELUQASASA-N
    InChI
    1S/C27H26ClF3N6O3.C9H9NO3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37;show more
    Synonyms
    AMY38702 | EX-A1619 | 2-benzamidoacetic acid, ((S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)pheny...
  5. LP 533401 hydrochloride
    CAS: 1040526-12-2 Formula: C27H22F4N4O3・HCl Molecular Weight: 562.94
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: L342412
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    IUPAC Name
    (2S)-2-amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-[4-(3-fluorophenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid;hydrochloride
    SMILES
    C1=CC(=CC(=C1)F)C2=CC=C(C=C2)C(C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)CC(C(=O)O)N)N.Cl
    InChIKey
    BHBWZCUMIXCDPM-CHXZROHQSA-N
    InChI
    1S/C27H22F4N4O3.ClH/c28-20-3-1-2-19(13-20)16-8-10-18(11-9-16)24(27(29,30)31)38-23-14-22(34-26(33)35-23)17-6-4-15(5-7-17)12-21(32)25(36)37;/h1-11,13-14show more
    Synonyms
    LP-533401 | LP533401
  6. 4-Chloro-DL-phenylalanine, Inhibitor of L-Phenylalanine hydroxylase ;Inhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2
    CAS: 7424-00-2 Formula: C9H10ClNO2 Molecular Weight: 199.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C136727
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    Technical Identifiers
    IUPAC Name
    2-amino-3-(4-chlorophenyl)propanoic acid
    SMILES
    C1=CC(=CC=C1CC(C(=O)O)N)Cl
    InChIKey
    NIGWMJHCCYYCSF-UHFFFAOYSA-N
    InChI
    1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
    Synonyms
    2-amino-3-(4-chlorophenyl)propanoic acid | Fenchlonine | C-Pal | DL-3-(p-Chlorophenyl)alanine | DL-p-Chlorophenylalan...
  7. 4-Chloro-DL-phenylalanine methyl ester hydrochloride
    CAS: 14173-40-1 EC Number: 238-024-0 Formula: C10H12ClNO2·HCl Molecular Weight: 250.12
    ● In Stock — US warehouse, ships to EU* Item #: C117072
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    Technical Identifiers
    IUPAC Name
    methyl 2-amino-3-(4-chlorophenyl)propanoate;hydrochloride
    SMILES
    COC(=O)C(CC1=CC=C(C=C1)Cl)N.Cl
    InChIKey
    GCBCWTWQAFLKJG-UHFFFAOYSA-N
    InChI
    1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
    Synonyms
    SMR001230706 | A807800 | CCG-221615 | Tox21_500311 | DL-p-Chlorophenylalanine methyl ester HCl | EN300-7387742 | meth...
  8. 4-Chloro-L-phenylalanine(L-PCPA)
    CAS: 14173-39-8 EC Number: 238-023-5 Formula: C9H10ClNO2 Molecular Weight: 199.63
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C100471
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    Technical Identifiers
    IUPAC Name
    (2S)-2-amino-3-(4-chlorophenyl)propanoic acid
    SMILES
    C1=CC(=CC=C1CC(C(=O)O)N)Cl
    InChIKey
    NIGWMJHCCYYCSF-QMMMGPOBSA-N
    InChI
    1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1
    Synonyms
    L-PCPA | (S)-4-CHLOROPHENYLALANINE | 4-Chloro-3-phenyl-L-alanine | PD132687 | SNM151OE2C | DTXSID10161813 | L-Phenyla...
  9. 4-Chloro-DL-phenylalanine, Inhibitor of L-Phenylalanine hydroxylase ;Inhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2
    CAS: 7424-00-2 Formula: C9H10ClNO2 Molecular Weight: 199.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: C425782
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    Technical Identifiers
    IUPAC Name
    2-amino-3-(4-chlorophenyl)propanoic acid
    SMILES
    C1=CC(=CC=C1CC(C(=O)O)N)Cl
    InChIKey
    NIGWMJHCCYYCSF-UHFFFAOYSA-N
    InChI
    1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
    Synonyms
    CP-10188 | AB02502 | CP 10188 | AB00241 | AS-49808 | R5J7E3L9SP | DTXSID4045139 | NCGC00024889-05 | Phenylalanine, 4-...
  10. ACT-678689
    CAS: 1783256-96-1 Formula: C23H22ClFN6O4S2 Molecular Weight: 565.04
    ● In Stock — US warehouse, ships to EU* Item #: A413429
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    IUPAC Name
    N-[6-chloro-5-[2-[(12S)-12-(2-fluoro-4-methylphenyl)-4-methyl-5-thia-2,3,7,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),3,6-trien-11-yl]-2-oxoethoxy]pyrishow more
    SMILES
    CC1=CC(=C(C=C1)C2C3=C(CCN2C(=O)COC4=C(N=C(C=C4)NS(=O)(=O)C)Cl)N=C5N3N=C(S5)C)F
    InChIKey
    XGWSHBGTWKYXMM-FQEVSTJZSA-N
    InChI
    1S/C23H22ClFN6O4S2/c1-12-4-5-14(15(25)10-12)20-21-16(26-23-31(21)28-13(2)36-23)8-9-30(20)19(32)11-35-17-6-7-18(27-22(17)24)29-37(3,33)34/h4-7,10,20H,8show more
  11. LX1606, Tryptophan 5-hydroxylase inhibitor
    CAS: 1137608-69-5 EC Number: 812-364-5 PubChem CID: 25253377 Formula: C36H35ClF3N7O6 Molecular Weight: 754.17
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L420690
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    Technical Identifiers
    IUPAC Name
    2-benzamidoacetic acid;ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyshow more
    SMILES
    CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N.C1=CC=C(C=C1)C(=O)NCC(=O)O
    InChIKey
    XSFPZBUIBYMVEA-CELUQASASA-N
    InChI
    1S/C27H26ClF3N6O3.C9H9NO3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37;show more
    Synonyms
    AMY38702 | EX-A1619 | 2-benzamidoacetic acid, ((S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)pheny...
  12. rodatristat ethyl, Tryptophan 5-hydroxylase 1 inhibitor
    CAS: 1673571-51-1 PubChem CID: 92045025 Formula: C29H31ClF3N5O3 Molecular Weight: 590.04
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: R613266
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    Technical Identifiers
    IUPAC Name
    ethyl (3S)-8-[2-amino-6-[(1R)-1-(4-chloro-2-phenylphenyl)-2,2,2-trifluoroethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylate
    SMILES
    CCOC(=O)[C@H]1NCC2(C1)CCN(CC2)c1cc(nc(n1)N)O[C@@H](C(F)(F)F)c1ccc(cc1c1ccccc1)Cl
    InChIKey
    TZSZZENYCISATO-WIOPSUGQSA-N
    InChI
    1S/C29H31ClF3N5O3/c1-2-40-26(39)22-16-28(17-35-22)10-12-38(13-11-28)23-15-24(37-27(34)36-23)41-25(29(31,32)33)20-9-8-19(30)14-21(20)18-6-4-3-5-7-18/h3show more
    Synonyms
    Rodatristat ethyl | KAR5585 | Rodatristat ethyl [USAN] | 507FY6OL37 | 2,8-Diazaspiro(4.5)decane-3-carboxylic acid | R...
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Frequently Asked Questions

Which compounds are listed for Tryptophan Hydroxylase?
Compounds associated with Tryptophan Hydroxylase are grouped here under the Metabolic Enzyme/Protease classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Tryptophan Hydroxylase sit within Metabolic Enzyme/Protease?
Tryptophan Hydroxylase is one target listing within the Metabolic Enzyme/Protease classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Tryptophan Hydroxylase?
For compounds listed under Tryptophan Hydroxylase, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Tryptophan Hydroxylase?
Browse the parent Metabolic Enzyme/Protease listing to reach targets neighbouring Tryptophan Hydroxylase, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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