Stem Cell/Wnt - γ-secretase Supplier | High Purity

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RO4929097, Gamma-secretase inhibitor
CAS: 847925-91-1 PubChem CID: 49867930 Formula: C₂₂H₂₀F₅N₃O₃ Molecular Weight: 469.4

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: R127403
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Technical Identifiers

IUPAC Name

2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide

SMILES

CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O

InChIKey
OJPLJFIFUQPSJR-INIZCTEOSA-N

InChI

1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,2show more

Synonyms
NCGC00263162-01 | Propanediamide, N-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pen...
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NNC 26-9100, Agonist of SST 4 receptor
CAS: 199522-35-5 Formula: C₂₂H₂₅N₆Cl₂SBr Molecular Weight: 556.35

Solid Moligand™ ? ≥99%(HPLC)

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IUPAC Name

1-[3-[(5-bromopyridin-2-yl)-[(3,4-dichlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea

SMILES

C1=CC(=C(C=C1CN(CCCNC(=S)NCCCC2=CN=CN2)C3=NC=C(C=C3)Br)Cl)Cl

InChIKey
UREJDUPKGMFJRU-UHFFFAOYSA-N

InChI

1S/C22H25BrCl2N6S/c23-17-5-7-21(29-12-17)31(14-16-4-6-19(24)20(25)11-16)10-2-9-28-22(32)27-8-1-3-18-13-26-15-30-18/h4-7,11-13,15H,1-3,8-10,14H2,(H,26,show more

Synonyms
1-(3-(n-(5-bromopyridin-2-yl)-n-(3,4-dichlorobenzyl)amino)propyl)-3-(3-(1h-imidazol-4-yl)propyl)thiourea | AKOS027470...
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MRK 560
CAS: 677772-84-8 EC Number: 112-628-3 Formula: C₁₉H₁₇ClF₅NO₄S₃ Molecular Weight: 517.92

Solid Moligand™ ? ≥99%(HPLC)

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IUPAC Name

N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide

SMILES

C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

InChIKey
WDZVWDXOIGQJIO-UHFFFAOYSA-N

InChI

1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2

Synonyms
N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide | N-((1s,4s)-...
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PF-3084014, Gamma-secretase inhibitor
CAS: 1290543-63-3 Formula: C₂₇H₄₁F₂N₅O Molecular Weight: 489.64

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: P127448
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IUPAC Name

(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide

SMILES

CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F

InChIKey
VFCRKLWBYMDAED-REWPJTCUSA-N

InChI

1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-1show more

Synonyms
NCGC00091375-02 | A11993 | A910640 | EX-A855 | PF3084014 | PF-3084014 | (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydrona...
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LY-411575
CAS: 209984-57-6 Formula: C₂₆H₂₃F₂N₃O₄ Molecular Weight: 479.48

Solid ≥98%

● In Stock — US warehouse, ships to EU* Item #: L125846
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IUPAC Name

(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

SMILES

CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O

InChIKey
ULSSJYNJIZWPSB-CVRXJBIPSA-N

InChI

1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,show more

Synonyms
AC-32717 | LY 411,575 | N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibe...
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YO-01027
CAS: 209984-56-5 PubChem CID: 11454028 Formula: C₂₆H₂₃F₂N₃O₃ Molecular Weight: 463.48

≥97%

● In Stock — US warehouse, ships to EU* Item #: Y129283
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IUPAC Name

(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

SMILES

CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

InChIKey
QSHGISMANBKLQL-OWJWWREXSA-N

InChI

1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(show more

Synonyms
Dibenzazepine (Deshydroxy LY 411575) | NCGC00263188-03 | SB47619 | SCHEMBL3046688 | C26H23F2N3O3 | SW219340-1 | EX-A0...
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DAPT
CAS: 208255-80-5 Formula: C₂₃H₂₆F₂N₂O₄ Molecular Weight: 432.46

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: D126677
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IUPAC Name

tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

SMILES

CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

InChIKey
DWJXYEABWRJFSP-XOBRGWDASA-N

InChI

1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,2show more

Synonyms
Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)- | MRF-0000012 | (S)-tert...
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MK-0752
CAS: 471905-41-6 Formula: C₂₁H₂₁ClF₂O₄S Molecular Weight: 442.91

Solid Moligand™ ? ≥97%

● In Stock — US warehouse, ships to EU* Item #: M126008
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Technical Identifiers

IUPAC Name

3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid

SMILES

C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

InChIKey
XCGJIFAKUZNNOR-UHFFFAOYSA-N

InChI

1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)

Synonyms
3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic Acid | 5-O-Demethyltangeretin | SCHEMBL18288...
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Avagacestat, Gamma-secretase inhibitor
CAS: 1146699-66-2 Formula: C₂₀H₁₇ClF₄N₄O₄S Molecular Weight: 520.89

Moligand™ ? ≥99%

● In Stock — US warehouse, ships to EU* Item #: B126453
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IUPAC Name

(2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

SMILES

C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl

InChIKey
XEAOPVUAMONVLA-QGZVFWFLSA-N

InChI

1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,2show more

Synonyms
DB11893 | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropen...
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E 2012
CAS: 870843-42-8 Formula: C₂₅H₂₆FN₃O₂ Molecular Weight: 419.49

Moligand™ ? ≥98%(HPLC)

● In Stock — US warehouse, ships to EU* Item #: E288274
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IUPAC Name

(3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one

SMILES

CC1=CN(C=N1)C2=C(C=C(C=C2)C=C3CCCN(C3=O)C(C)C4=CC=C(C=C4)F)OC

InChIKey
PUOAETJYKQITMO-LANLRWRYSA-N

InChI

1S/C25H26FN3O2/c1-17-15-28(16-27-17)23-11-6-19(14-24(23)31-3)13-21-5-4-12-29(25(21)30)18(2)20-7-9-22(26)10-8-20/h6-11,13-16,18H,4-5,12H2,1-3H3/b21-13+show more

Synonyms
(3e)-1-[(1s)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]methylene]-2-piperidinone | F...
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Sulindac Sulfide
CAS: 32004-67-4 PubChem CID: 6034911 Formula: C₂₀H₁₇FO₂S Molecular Weight: 340.41

≥98%

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IUPAC Name

2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]acetic acid

SMILES

CC1=C(C2=C(C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O

InChIKey
LFWHFZJPXXOYNR-RQZCQDPDSA-N

InChI

1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+

Synonyms
(E/Z)-Sulindac sulfide | J-018597 | {5-Fluoro-2-methyl-1-[4-(methylsulphanyl)benzylidene]-1H-inden-3-yl}acetic acid |...
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L-685,458
CAS: 292632-98-5 Formula: C₃₉H₅₂N₄O₆ Molecular Weight: 672.85

≥98%

● In Stock — US warehouse, ships to EU* Item #: L275059
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IUPAC Name

tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylshow more

SMILES

CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O

InChIKey
MURCDOXDAHPNRQ-ZJKZPDEISA-N

InChI

1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)show more

Synonyms
NCGC00165962-01 | HY-19369 | L 458 | (5S)-[tert-butoxycarbonylamino-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl]-L-Leu-...

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Frequently Asked Questions

Which compounds are listed for γ-secretase?

Compounds associated with γ-secretase are grouped here under the Stem Cell/Wnt classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.

How does γ-secretase sit within Stem Cell/Wnt?

γ-secretase is one target listing within the Stem Cell/Wnt classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.

What data should I check before ordering a compound from γ-secretase?

For compounds listed under γ-secretase, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

How do I find related targets or backup compounds for γ-secretase?

Browse the parent Stem Cell/Wnt listing to reach targets neighbouring γ-secretase, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.