Neuronal Signaling - γ-secretase Supplier | High Purity

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RO4929097, Gamma-secretase inhibitor
CAS: 847925-91-1 PubChem CID: 49867930 Formula: C₂₂H₂₀F₅N₃O₃ Molecular Weight: 469.4

Moligand™ ? ≥98%

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IUPAC Name

2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide

SMILES

CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O

InChIKey
OJPLJFIFUQPSJR-INIZCTEOSA-N

InChI

1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,2show more

Synonyms
NCGC00263162-01 | Propanediamide, N-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pen...
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NNC 26-9100, Agonist of SST 4 receptor
CAS: 199522-35-5 Formula: C₂₂H₂₅N₆Cl₂SBr Molecular Weight: 556.35

Solid Moligand™ ? ≥99%(HPLC)

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IUPAC Name

1-[3-[(5-bromopyridin-2-yl)-[(3,4-dichlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea

SMILES

C1=CC(=C(C=C1CN(CCCNC(=S)NCCCC2=CN=CN2)C3=NC=C(C=C3)Br)Cl)Cl

InChIKey
UREJDUPKGMFJRU-UHFFFAOYSA-N

InChI

1S/C22H25BrCl2N6S/c23-17-5-7-21(29-12-17)31(14-16-4-6-19(24)20(25)11-16)10-2-9-28-22(32)27-8-1-3-18-13-26-15-30-18/h4-7,11-13,15H,1-3,8-10,14H2,(H,26,show more

Synonyms
1-(3-(n-(5-bromopyridin-2-yl)-n-(3,4-dichlorobenzyl)amino)propyl)-3-(3-(1h-imidazol-4-yl)propyl)thiourea | AKOS027470...
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MRK 560
CAS: 677772-84-8 EC Number: 112-628-3 Formula: C₁₉H₁₇ClF₅NO₄S₃ Molecular Weight: 517.92

Solid Moligand™ ? ≥99%(HPLC)

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IUPAC Name

N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide

SMILES

C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

InChIKey
WDZVWDXOIGQJIO-UHFFFAOYSA-N

InChI

1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2

Synonyms
N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide | N-((1s,4s)-...
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PF-3084014, Gamma-secretase inhibitor
CAS: 1290543-63-3 Formula: C₂₇H₄₁F₂N₅O Molecular Weight: 489.64

Moligand™ ? ≥98%

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IUPAC Name

(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide

SMILES

CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F

InChIKey
VFCRKLWBYMDAED-REWPJTCUSA-N

InChI

1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-1show more

Synonyms
NCGC00091375-02 | A11993 | A910640 | EX-A855 | PF3084014 | PF-3084014 | (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydrona...
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LY-411575
CAS: 209984-57-6 Formula: C₂₆H₂₃F₂N₃O₄ Molecular Weight: 479.48

Solid ≥98%

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IUPAC Name

(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

SMILES

CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O

InChIKey
ULSSJYNJIZWPSB-CVRXJBIPSA-N

InChI

1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,show more

Synonyms
AC-32717 | LY 411,575 | N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibe...
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YO-01027
CAS: 209984-56-5 PubChem CID: 11454028 Formula: C₂₆H₂₃F₂N₃O₃ Molecular Weight: 463.48

≥97%

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IUPAC Name

(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

SMILES

CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

InChIKey
QSHGISMANBKLQL-OWJWWREXSA-N

InChI

1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(show more

Synonyms
Dibenzazepine (Deshydroxy LY 411575) | NCGC00263188-03 | SB47619 | SCHEMBL3046688 | C26H23F2N3O3 | SW219340-1 | EX-A0...
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DAPT
CAS: 208255-80-5 Formula: C₂₃H₂₆F₂N₂O₄ Molecular Weight: 432.46

Moligand™ ? ≥98%

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IUPAC Name

tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

SMILES

CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

InChIKey
DWJXYEABWRJFSP-XOBRGWDASA-N

InChI

1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,2show more

Synonyms
Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)- | MRF-0000012 | (S)-tert...
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MK-0752
CAS: 471905-41-6 Formula: C₂₁H₂₁ClF₂O₄S Molecular Weight: 442.91

Solid Moligand™ ? ≥97%

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Technical Identifiers

IUPAC Name

3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid

SMILES

C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

InChIKey
XCGJIFAKUZNNOR-UHFFFAOYSA-N

InChI

1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)

Synonyms
3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic Acid | 5-O-Demethyltangeretin | SCHEMBL18288...
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Avagacestat, Gamma-secretase inhibitor
CAS: 1146699-66-2 Formula: C₂₀H₁₇ClF₄N₄O₄S Molecular Weight: 520.89

Moligand™ ? ≥99%

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IUPAC Name

(2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

SMILES

C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl

InChIKey
XEAOPVUAMONVLA-QGZVFWFLSA-N

InChI

1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,2show more

Synonyms
DB11893 | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropen...
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E 2012
CAS: 870843-42-8 Formula: C₂₅H₂₆FN₃O₂ Molecular Weight: 419.49

Moligand™ ? ≥98%(HPLC)

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IUPAC Name

(3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one

SMILES

CC1=CN(C=N1)C2=C(C=C(C=C2)C=C3CCCN(C3=O)C(C)C4=CC=C(C=C4)F)OC

InChIKey
PUOAETJYKQITMO-LANLRWRYSA-N

InChI

1S/C25H26FN3O2/c1-17-15-28(16-27-17)23-11-6-19(14-24(23)31-3)13-21-5-4-12-29(25(21)30)18(2)20-7-9-22(26)10-8-20/h6-11,13-16,18H,4-5,12H2,1-3H3/b21-13+show more

Synonyms
(3e)-1-[(1s)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]methylene]-2-piperidinone | F...
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Sulindac Sulfide
CAS: 32004-67-4 PubChem CID: 6034911 Formula: C₂₀H₁₇FO₂S Molecular Weight: 340.41

≥98%

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IUPAC Name

2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]acetic acid

SMILES

CC1=C(C2=C(C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O

InChIKey
LFWHFZJPXXOYNR-RQZCQDPDSA-N

InChI

1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+

Synonyms
(E/Z)-Sulindac sulfide | J-018597 | {5-Fluoro-2-methyl-1-[4-(methylsulphanyl)benzylidene]-1H-inden-3-yl}acetic acid |...
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L-685,458
CAS: 292632-98-5 Formula: C₃₉H₅₂N₄O₆ Molecular Weight: 672.85

≥98%

● In Stock — US warehouse, ships to EU* Item #: L275059
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IUPAC Name

tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylshow more

SMILES

CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O

InChIKey
MURCDOXDAHPNRQ-ZJKZPDEISA-N

InChI

1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)show more

Synonyms
NCGC00165962-01 | HY-19369 | L 458 | (5S)-[tert-butoxycarbonylamino-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl]-L-Leu-...

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Frequently Asked Questions

How is the γ-secretase listing put together?

It draws on reported γ-secretase annotations within Neuronal Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.

How do I choose a γ-secretase modulator for my assay?

Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the γ-secretase entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.

Which specifications matter most for γ-secretase compounds?

Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For γ-secretase work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

What if the γ-secretase compound I need is not listed?

Search by CAS number or SMILES first, since analogs of γ-secretase compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.