Antifolate
Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.
109 products
Popular Products
- Levomefolate calciumCAS: 151533-22-1 Formula: C20H23CaN7O6 Molecular Weight: 497.52● In Stock — US warehouse, ships to EU* Item #: L302964View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
- SMILES
- CN1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]
- InChIKey
- VWBBRFHSPXRJQD-QNTKWALQSA-L
- InChI
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- Synonyms
- CALCIUM L-5-METHYLTETRAHYDROFOLATE [DSC] | Rhenium, wire reel, 0.2m, diameter 0.076mm, annealed, 99.97% | BAY86-7660 ...
- Folinic acid, calcium salt pentahydrateCAS: 6035-45-6 Formula: C20H21CaN7O7.5H2O Molecular Weight: 601.59● In Stock — US warehouse, ships to EU* Item #: F304111View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;pentahydrate
- SMILES
- C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]
- InChIKey
- NPPBLUASYYNAIG-ZIGBGYJWSA-L
- InChI
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- Synonyms
- CALCII FOLINAS [WHO-IP LATIN] | 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (+)-, (Z)-2-b...
- 10-Formyl Folic AcidCAS: 134-05-4 Formula: C20H19N7O7 Molecular Weight: 469.41● In Stock — US warehouse, ships to EU* Item #: F334434View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
- SMILES
- C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)N(CC2=CN=C3C(=N2)C(=O)NC(=N3)N)C=O
- InChIKey
- UGWUWNVTCLDEOG-ZDUSSCGKSA-N
- InChI
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- Synonyms
- 10-Formylpteroylglutamic Acid | 10-Formyldihydropteroylglutamate | L-GLUTAMIC ACID, N-(4-(((2-AMINO-3,4-DIHYDRO-4-OXO...
- Pemetrexed, Inhibitor of dihydrofolate reductase;Inhibitor of phosphoribosylglycinamide formyltransferase; phosphoribosylglycinamide synthetase; phosphoribosylaminoimidazole synthetase;Inhibitor of thymidylate synthetaseMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: P125303View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
- SMILES
- C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
- InChIKey
- WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
- InChI
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- Synonyms
- GTPL5443 | N-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]phenyl}carbonyl)-L-glutamic acid...
- Pemetrexed, GAR transformylase inhibitorCAS: 150399-23-8 Formula: C20H19N5Na2O6 Molecular Weight: 471.37● In Stock — US warehouse, ships to EU* Item #: P129841View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
- SMILES
- C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
- InChIKey
- NYDXNILOWQXUOF-GXKRWWSZSA-L
- InChI
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- Synonyms
- CAS-150399-23-8 | Pemetrexed Disodium is known as a Thymidylate synthase inhibitor. | PEMETREXED DISODIUM [USP MONOGR...
- TrimethoprimSolid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%● In Stock — US warehouse, ships to EU* Item #: T129928View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
- SMILES
- COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
- InChIKey
- IEDVJHCEMCRBQM-UHFFFAOYSA-N
- InChI
- 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
- Synonyms
- 5-(3,4,5-Trimethoxybenzyl)-2,4-diaminopyrimidine | Resprim | Bactoprim | Espectrin | Purbal | Roubal | Streptoplus | ...
- Pemetrexed disodium hydrateCAS: 357166-30-4 EC Number: 604-733-2, 814-356-7 PubChem CID: 135564527 Formula: C20H21N5O6·5/2H2O·2Na Molecular Weight: 516.42● In Stock — US warehouse, ships to EU* Item #: P140269View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- tetrasodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;pentahydrate
- SMILES
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- InChIKey
- ZCTCZKWJFTYNMZ-WKUCUCPSSA-J
- InChI
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- Synonyms
- UNII-F4GSH45R4C | Pemetrexed accord | (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)be...
- Aminopterin Hydrate● In Stock — US warehouse, ships to EU* Item #: A107171View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
- SMILES
- Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
- InChIKey
- TVZGACDUOSZQKY-LBPRGKRZSA-N
- InChI
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- Synonyms
- CAS-54-62-6 | Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-L(+)-glutamova | (2S)-2-[[4-[[(2,4-Diamin...
- Pralatrexate, Dihydrofolate reductase inhibitorCAS: 146464-95-1 Formula: C23H23N7O5 Molecular Weight: 477.47Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: P125726View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid
- SMILES
- C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
- InChIKey
- OGSBUKJUDHAQEA-WMCAAGNKSA-N
- InChI
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- Synonyms
- (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid | CHEBI:39196 | (2S)-2-((4-...
- 7-Bromo-2,4-diaminoquinazolineCAS: 137553-43-6 Formula: C8H7BrN4 Molecular Weight: 239.07● In Stock — US warehouse, ships to EU* Item #: B181364View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 7-bromoquinazoline-2,4-diamine
- SMILES
- C1=CC2=C(C=C1Br)N=C(N=C2N)N
- InChIKey
- YPWBLOIRVSSESG-UHFFFAOYSA-N
- InChI
- 1S/C8H7BrN4/c9-4-1-2-5-6(3-4)12-8(11)13-7(5)10/h1-3H,(H4,10,11,12,13)
- Synonyms
- DHFR-IN-3 | GS-4262 | 2,4-Quinazolinediamine, 7-bromo- | DTXSID20160236 | J-007040 | SY032047 | 7-Bromo-2,4-diaminoqu...
- Folinic acid calcium salt hydrateCAS: 1492-18-8 Formula: C20H21CaN7O7 · xH2O Molecular Weight: 511.50 (anhydrous basis)Solid ≥98%● In Stock — US warehouse, ships to EU* Item #: F107310View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
- SMILES
- [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
- InChIKey
- KVUAALJSMIVURS-ZEDZUCNESA-L
- InChI
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- Synonyms
- AMPHOTERICIN B (USP-RS) | Calcii folinas | BUDESONIDE COMPONENT OF BREZTRI | Calcifolin | Folinac | Leucovorin calciu...
- Diaveridine● In Stock — US warehouse, ships to EU* Item #: D137262View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
- SMILES
- COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC
- InChIKey
- LDBTVAXGKYIFHO-UHFFFAOYSA-N
- InChI
- 1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)
- Synonyms
- CCG-213021 | 2, 5-[(3,4-dimethoxyphenyl)methyl]- | Diaveridina | EN300-7440332 | 5-[(3,4-dimethoxyphenyl)methyl]pyrim...
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
How is the Antifolate listing put together?
It draws on reported Antifolate annotations within Cell Cycle/DNA Damage and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an Antifolate modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the Antifolate entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for Antifolate compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For Antifolate work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the Antifolate compound I need is not listed?
Search by CAS number or SMILES first, since analogs of Antifolate compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.