Cell Cycle/DNA Damage - Checkpoint Kinase (Chk) Supplier | High Purity

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SB 218078, Inhibitor of checkpoint kinase 1
CAS: 135897-06-2 PubChem CID: 3387354 Formula: C₂₄H₁₅N₃O₃ Molecular Weight: 393.39

Moligand™ ? ≥98%(HPLC)

◐ .Made to order · 8–12 wks Item #: S287033
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IUPAC Name

28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione

SMILES

C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O

InChIKey
OTPNDVKVEAIXTI-UHFFFAOYSA-N

InChI

1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29show more

Synonyms
EX-A4201 | HMS3229O08 | J-006782 | AKOS024457167 | S6U3J3UP11 | NCGC00167774-01 | SB218078 | SB-218078 | (15S,18R)-28...
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NSC 109555 ditosylate
CAS: 66748-43-4 PubChem CID: 12449850 Formula: C₁₉H₂₄N₁₀O•2C₇H₈O₃S Molecular Weight: 752.86

≥98%(HPLC)

◐ .Made to order · 8–12 wks Item #: N287659
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IUPAC Name

1,3-bis[4-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]urea;4-methylbenzenesulfonic acid

SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(=NN=C(N)N)C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)C(=NN=C(N)N)C

InChIKey
DIQGNVANOSOABS-XMDRLFCYSA-N

InChI

1S/C19H24N10O.2C7H8O3S/c1-11(26-28-17(20)21)13-3-7-15(8-4-13)24-19(30)25-16-9-5-14(6-10-16)12(2)27-29-18(22)23;2*1-6-2-4-7(5-3-6)11(8,9)10/h3-10H,1-2Hshow more

Synonyms
DDUG | 2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)
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PF-477736, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2
CAS: 952021-60-2 Formula: C₂₂H₂₅N₇O₂ Molecular Weight: 419.48

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: P120184
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IUPAC Name

(2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-6-yl]acetamide

SMILES

CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2

InChIKey
NDEXUOWTGYUVGA-LJQANCHMSA-N

InChI

1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(show more

Synonyms
(2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0,4,13]trideca-1,4(13),5...
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AZD 7762 hydrochloride
CAS: 1246094-78-9 Formula: C₁₇H₁₉FN₄O₂S•HCl Molecular Weight: 398.88

≥98%(HPLC)

● In Stock — US warehouse, ships to EU* Item #: A287147
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IUPAC Name

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride

SMILES

C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N.Cl

InChIKey
WFZBLOIXZRZEDG-YDALLXLXSA-N

InChI

1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1Hshow more

Synonyms
MLS006010750 | HY-10992A | SCHEMBL19457662 | 5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-piperidin-3...
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LY2603618, Serine/threonine-protein kinase Chk1 inhibitor
CAS: 911222-45-2 Formula: C₁₈H₂₂BrN₅O₃ Molecular Weight: 436.3

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: L126277
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IUPAC Name

1-[5-bromo-4-methyl-2-[[(2S)-morpholin-2-yl]methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea

SMILES

CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OCC3CNCCO3

InChIKey
SYYBDNPGDKKJDU-ZDUSSCGKSA-N

InChI

1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-show more

Synonyms
AC-32839 | NCGC00343768-01 | AKOS027422721 | Q27088510 | 71803L5F4S | EX-A426 | RABUSERTIB [WHO-DD] | D10397 | 2-(3,4...
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AZD7762, Serine/threonine-protein kinase Chk1 inhibitor
CAS: 860352-01-8 EC Number: 804-400-3 Formula: C₁₇H₁₉FN₄O₂S Molecular Weight: 362.42

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: A127862
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IUPAC Name

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide

SMILES

C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N

InChIKey
IAYGCINLNONXHY-LBPRGKRZSA-N

InChI

1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/t12-/m0show more

Synonyms
5D822Y3L1H | H1206 | 4,4'-DIMETHOXYTHIOCARBANILIDE | BS-22319 | C17H19FN4O2S | CCG-264907 | J-502468 | AZD 7762 | BDB...
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CCT 241533 dihydrochloride
CAS: 1962925-28-5 PubChem CID: 137025388 Formula: C₂₃H₂₇FN₄O₄.₂HCl Molecular Weight: 515.41

≥98%(HPLC)

◐ .Made to order · 8–12 wks Item #: C287966
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IUPAC Name

4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;dihydrochloride

SMILES

CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl.Cl

InChIKey
VCFVLTMSBOZYOU-FXKISCCRSA-N

InChI

1S/C23H27FN4O4.2ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;;/h5-9,15,17,25,29-30H,10-11H2show more

Synonyms
(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihyd...
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CCT245737, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2
CAS: 1489389-18-5 Formula: C₁₆H₁₆F₃N₇O Molecular Weight: 379.34

Moligand™ ? 10mM in DMSO

● In Stock — US warehouse, ships to EU* Item #: C421745
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Technical Identifiers

IUPAC Name

5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile

SMILES

C1COC(CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N

InChIKey
YBYYWUUUGCNAHQ-LLVKDONJSA-N

InChI

1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1

Synonyms
(R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile | (R)5-((4-((Mo...
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CCT245737, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2
CAS: 1489389-18-5 Formula: C₁₆H₁₆F₃N₇O Molecular Weight: 379.34

Moligand™ ? ≥99%

● In Stock — US warehouse, ships to EU* Item #: C413955
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Technical Identifiers

IUPAC Name

5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile

SMILES

C1COC(CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N

InChIKey
YBYYWUUUGCNAHQ-LLVKDONJSA-N

InChI

1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1

Synonyms
(R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile | (R)5-((4-((Mo...
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CCT241533, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2
CAS: 1262849-73-9 Formula: C₂₃H₂₇FN₄O₄ Molecular Weight: 442.48

Moligand™ ?

◐ .Made to order · 8–12 wks Item #: C125629
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IUPAC Name

4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol

SMILES

CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O

InChIKey
HZASIAXCPXTISQ-NVXWUHKLSA-N

InChI

1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25,29-30H,10-11H2,1-4H3,show more

Synonyms
A922008 | 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol ...
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CHIR-124, Inhibitor of checkpoint kinase 1
CAS: 405168-58-3 PubChem CID: 135399748 Formula: C₂₃H₂₂ClN₅O Molecular Weight: 419.91

Moligand™ ? ≥99%

● In Stock — US warehouse, ships to EU* Item #: C125171
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IUPAC Name

4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one

SMILES

C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5

InChIKey
MOVBBVMDHIRCTG-LJQANCHMSA-N

InChI

1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(show more

Synonyms
NCGC00346626-04 | 4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One | (S)...
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Chk2 inhibitor
CAS: 724708-21-8 Formula: C₁₅H₁₅N₅O₂ Molecular Weight: 295.3

≥95%

◐ .Made to order · 8–12 wks Item #: C337162
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IUPAC Name

5-(2-amino-4-hydroxy-1H-imidazol-5-yl)-3,4-dihydro-2H-azepino[3,4-b]indol-1-one

SMILES

C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O

InChIKey
RZEPRPGFGRQXDI-UHFFFAOYSA-N

InChI

1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,22H,5-6H2,(H,17,21)(H3,16,19,20)

Synonyms
5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidine)-3,4,5,10-2H-azepino[3,4-b]indol-1-one

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Frequently Asked Questions

Which compounds are listed for Checkpoint Kinase (Chk)?

Compounds associated with Checkpoint Kinase (Chk) are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.

How does Checkpoint Kinase (Chk) sit within Cell Cycle/DNA Damage?

Checkpoint Kinase (Chk) is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.

What data should I check before ordering a compound from Checkpoint Kinase (Chk)?

For compounds listed under Checkpoint Kinase (Chk), check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

How do I find related targets or backup compounds for Checkpoint Kinase (Chk)?

Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring Checkpoint Kinase (Chk), and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.