DYRK

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  1. Harmine Hydrochloride
    CAS: 343-27-1 EC Number: 206-443-8 Formula: C13H12N2O·HCl Molecular Weight: 248.71
    Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: H115850
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    IUPAC Name
    7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
    SMILES
    CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC.Cl
    InChIKey
    VNPLYCKZIUTKJM-UHFFFAOYSA-N
    InChI
    1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H
    Synonyms
    AC-34980 | Banisterine Hydrochloride | A-8200 | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | DTXCID10683...
  2. INDY
    CAS: 1169755-45-6 Formula: C12H13NO2S Molecular Weight: 235.3
    ● In Stock — US warehouse, ships to EU* Item #: I275280
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    IUPAC Name
    1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
    SMILES
    CCN1C2=C(C=CC(=C2)O)SC1=CC(=O)C
    InChIKey
    GCSZJMUFYOAHFY-UHFFFAOYSA-N
    InChI
    1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3
    Synonyms
    (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone | (Z)-1-(3-ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylid...
  3. ML 315 hydrochloride
    CAS: 1440251-53-5 PubChem CID: 127021037 Formula: C18H13Cl2N3O2.HCl Molecular Weight: 410.68
    ● In Stock — US warehouse, ships to EU* Item #: M288578
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    IUPAC Name
    5-(1,3-benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]pyrimidin-4-amine;hydrochloride
    SMILES
    C1OC2=C(O1)C=C(C=C2)C3=CN=CN=C3NCC4=CC(=CC(=C4)Cl)Cl.Cl
    InChIKey
    MNCDEAAKKQCKSX-UHFFFAOYSA-N
    InChI
    1S/C18H13Cl2N3O2.ClH/c19-13-3-11(4-14(20)6-13)7-22-18-15(8-21-9-23-18)12-1-2-16-17(5-12)25-10-24-16;/h1-6,8-9H,7,10H2,(H,21,22,23);1H
    Synonyms
    5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride
  4. ML-167
    CAS: 1285702-20-6 EC Number: 808-432-9 Formula: C19H17N3O3 Molecular Weight: 335.36
    ● In Stock — US warehouse, ships to EU* Item #: M274979
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    IUPAC Name
    [5-[4-[(5-methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanol
    SMILES
    CC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO
    InChIKey
    ROCFOIBAEVAOLQ-UHFFFAOYSA-N
    InChI
    1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
    Synonyms
    NCGC00188654-04 | [5-(4-{[(5-METHYLFURAN-2-YL)METHYL]AMINO}QUINAZOLIN-6-YL)FURAN-2-YL]METHANOL | BDBM50342913 | AC-35...
  5. AZ 191, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1B
    CAS: 1594092-37-1 Formula: C24H27N7O Molecular Weight: 429.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: A288802
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    IUPAC Name
    N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
    SMILES
    CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC
    InChIKey
    ZYVXTMKTGDARKR-UHFFFAOYSA-N
    InChI
    1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27show more
    Synonyms
    N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
  6. TC-S 7004
    CAS: 1386979-55-0 PubChem CID: 57523919 Formula: C23H17Cl2N5O4 Molecular Weight: 498.32
    ◐ .Made to order · 8–12 wks Item #: T288016
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    IUPAC Name
    N-[2-chloro-5-[(3-chlorophenyl)methylcarbamoyl]phenyl]-2-methoxy-7-oxo-8H-pyrido[2,3-d]pyrimidine-6-carboxamide
    SMILES
    COC1=NC=C2C=C(C(=O)NC2=N1)C(=O)NC3=C(C=CC(=C3)C(=O)NCC4=CC(=CC=C4)Cl)Cl
    InChIKey
    CQKBSRPVZZLCJE-UHFFFAOYSA-N
    InChI
    1S/C23H17Cl2N5O4/c1-34-23-27-11-14-8-16(22(33)29-19(14)30-23)21(32)28-18-9-13(5-6-17(18)25)20(31)26-10-12-3-2-4-15(24)7-12/h2-9,11H,10H2,1H3,(H,26,31)show more
    Synonyms
    N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-c...
  7. ID 8
    CAS: 147591-46-6 EC Number: 663-653-6 Formula: C16H14N2O4 Molecular Weight: 298.29
    ● In Stock — US warehouse, ships to EU* Item #: I287101
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    IUPAC Name
    1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
    SMILES
    CC1=C(C2=C(N1C3=CC=C(C=C3)OC)C=C(C=C2)O)[N+](=O)[O-]
    InChIKey
    VVZNWYXIOADGSW-UHFFFAOYSA-N
    InChI
    1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
    Synonyms
    BCP27795 | ID-8 | VVZNWYXIOADGSW-UHFFFAOYSA-N | 1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro- | AKOS000558433 ...
  8. Harmine, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1B
    CAS: 442-51-3 EC Number: 207-131-4 Formula: C13H12N2O Molecular Weight: 212.25
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: H107067
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    IUPAC Name
    7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
    SMILES
    CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
    InChIKey
    BXNJHAXVSOCGBA-UHFFFAOYSA-N
    InChI
    1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
    Synonyms
    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole | HARMINE | HMS3885E10 | Spectrum5_001914 | 9H-Pyrido(3,4-b)indole, 7-metho...
  9. LDN-192960
    CAS: 184582-62-5 Formula: C18H20N2O2S Molecular Weight: 328.43
    ● In Stock — US warehouse, ships to EU* Item #: L168104
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    IUPAC Name
    3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine
    SMILES
    COC1=CC2=C(C=C1)N=C3C=CC(=CC3=C2SCCCN)OC
    InChIKey
    ZFOMCSNUEHMROO-UHFFFAOYSA-N
    InChI
    1S/C18H20N2O2S/c1-21-12-4-6-16-14(10-12)18(23-9-3-8-19)15-11-13(22-2)5-7-17(15)20-16/h4-7,10-11H,3,8-9,19H2,1-2H3
    Synonyms
    AC-35777 | HY-13455 | BCP06879 | EX-A4806 | MFCD02752814 | CCRIS 8174 | 3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-a...
  10. LDN 209929 dihydrochloride
    CAS: 1784281-97-5 PubChem CID: 90488975 Formula: C17H17ClN2OS.2HCl Molecular Weight: 405.77
    ◐ .Made to order · 8–12 wks Item #: L287599
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    IUPAC Name
    3-(2-chloro-7-methoxyacridin-9-yl)sulfanylpropan-1-amine;dihydrochloride
    SMILES
    COC1=CC2=C(C=C1)N=C3C=CC(=CC3=C2SCCCN)Cl.Cl.Cl
    InChIKey
    WOCCOXNODBCCGK-UHFFFAOYSA-N
    InChI
    1S/C17H17ClN2OS.2ClH/c1-21-12-4-6-16-14(10-12)17(22-8-2-7-19)13-9-11(18)3-5-15(13)20-16;;/h3-6,9-10H,2,7-8,19H2,1H3;2*1H
    Synonyms
    3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
  11. Harmine
    CAS: 442-51-3 EC Number: 207-131-4 Formula: C13H12N2O Molecular Weight: 212.25
    Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: H107068
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    Technical Identifiers
    IUPAC Name
    7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
    SMILES
    CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
    InChIKey
    BXNJHAXVSOCGBA-UHFFFAOYSA-N
    InChI
    1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
    Synonyms
    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole | HARMINE | HMS3885E10 | Spectrum5_001914 | 9H-Pyrido(3,4-b)indole, 7-metho...
  12. AZ 191, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1B
    CAS: 1594092-37-1 Formula: C24H27N7O Molecular Weight: 429.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A421906
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    Technical Identifiers
    IUPAC Name
    N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
    SMILES
    CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC
    InChIKey
    ZYVXTMKTGDARKR-UHFFFAOYSA-N
    InChI
    1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27show more
    Synonyms
    N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
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Frequently Asked Questions

How is the DYRK listing put together?
It draws on reported DYRK annotations within Protein Tyrosine Kinase/RTK and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a DYRK modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the DYRK entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for DYRK compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For DYRK work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the DYRK compound I need is not listed?
Search by CAS number or SMILES first, since analogs of DYRK compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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