GCGR

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  1. Liraglutide, Glukagon-like peptide 1 receptor agonist
    CAS: 204656-20-2 EC Number: 810-818-7 Formula: C172H265N43O51 Molecular Weight: 3751.2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: L276430
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    IUPAC Name
    (2S)-5-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[show more
    SMILES
    CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(show more
    InChIKey
    YSDQQAXHVYUZIW-QCIJIYAXSA-N
    InChI
    1S/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-129(224)195-116(170(265)266)59-64-128(223)180-68-41-40-50-111(153(248)199-115(62-67-135show more
    Synonyms
    Liraglutida | N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)GLP-1-(7-37)-peptide | (4'-FURAN-2-YL-[4,5']BIPYRIMIDIN...
  2. Lixisenatide acetate
    CAS: 1997361-87-1 Formula: C215H347N61O65S.6C2H4O2 Molecular Weight: 4858.49(free base)
    ● In Stock — US warehouse, ships to EU* Item #: L275704
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    Synonyms
    AVE-010 | H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2 | AVE 010 | AVE0010 | LIXISENATIDE (MART.) | ZP 10 | H-L...
  3. NNC 0640, Allosteric modulator of glukagon receptor
    CAS: 307986-98-7 Formula: C29H31N7O4S Molecular Weight: 573.67
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: N286700
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    IUPAC Name
    4-[[4-cyclohexyl-N-[(3-methylsulfonylphenyl)carbamoyl]anilino]methyl]-N-(2H-tetrazol-5-yl)benzamide
    SMILES
    CS(=O)(=O)C1=CC=CC(=C1)NC(=O)N(CC2=CC=C(C=C2)C(=O)NC3=NNN=N3)C4=CC=C(C=C4)C5CCCCC5
    InChIKey
    PPTKULJUDJWTSA-UHFFFAOYSA-N
    InChI
    1S/C29H31N7O4S/c1-41(39,40)26-9-5-8-24(18-26)30-29(38)36(25-16-14-22(15-17-25)21-6-3-2-4-7-21)19-20-10-12-23(13-11-20)27(37)31-28-32-34-35-33-28/h5,8-show more
    Synonyms
    4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
  4. hGCGR Antagonist, Antagonist of glukagon receptor
    CAS: 438618-32-7 Formula: C20H30N2OS Molecular Weight: 346.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ◐ .Made to order · 8–12 wks Item #: G338729
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    IUPAC Name
    N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide
    SMILES
    CCC(CC)C(=O)NC1=C(C2=C(S1)CC(CC2)C(C)(C)CC)C#N
    InChIKey
    SWIBDWBSJSJQHL-UHFFFAOYSA-N
    InChI
    1S/C20H30N2OS/c1-6-13(7-2)18(23)22-19-16(12-21)15-10-9-14(11-17(15)24-19)20(4,5)8-3/h13-14H,6-11H2,1-5H3,(H,22,23)
    Synonyms
    MFCD01920208 | NCGC00340210-02 | AKOS017343007 | N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen...
  5. VU 0650991
    CAS: 488097-06-9 EC Number: 963-629-8 PubChem CID: 1941609 Formula: C16H11ClF6N4O2 Molecular Weight: 440.73
    ◐ .Made to order · 8–12 wks Item #: V288056
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    IUPAC Name
    7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione
    SMILES
    CN1C2=C(C(=O)N(C1=O)C)C(N=C(N2)C3=CC=C(C=C3)Cl)(C(F)(F)F)C(F)(F)F
    InChIKey
    MFEIZMHODFOWAT-UHFFFAOYSA-N
    InChI
    1S/C16H11ClF6N4O2/c1-26-11-9(12(28)27(2)13(26)29)14(15(18,19)20,16(21,22)23)25-10(24-11)7-3-5-8(17)6-4-7/h3-6H,1-2H3,(H,24,25)
    Synonyms
    7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
  6. BETP, Allosteric modulator of GLP-1 receptor
    CAS: 1371569-69-5 EC Number: 802-774-2 Formula: C20H17F3N2O2S Molecular Weight: 406.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: B131969
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    IUPAC Name
    2-ethylsulfinyl-4-(3-phenylmethoxyphenyl)-6-(trifluoromethyl)pyrimidine
    SMILES
    CCS(=O)C1=NC(=CC(=N1)C(F)(F)F)C2=CC(=CC=C2)OCC3=CC=CC=C3
    InChIKey
    NTDFYGSSDDMNHI-UHFFFAOYSA-N
    InChI
    1S/C20H17F3N2O2S/c1-2-28(26)19-24-17(12-18(25-19)20(21,22)23)15-9-6-10-16(11-15)27-13-14-7-4-3-5-8-14/h3-12H,2,13H2,1H3
    Synonyms
    NCGC00379201-03 | E78417 | 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine | BCP19312 | 2-eth...
  7. L-168,049, Antagonist of glukagon receptor
    CAS: 191034-25-0 Formula: C24H20BrClN2O Molecular Weight: 467.79
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: L287004
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    IUPAC Name
    4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
    SMILES
    CCCOC1=C(C=C(C=C1)Br)C2=C(NC(=C2)C3=CC=C(C=C3)Cl)C4=CC=NC=C4
    InChIKey
    HHBOWXZOLYQFNY-UHFFFAOYSA-N
    InChI
    1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
    Synonyms
    4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-(2,2,2-trifluoroacetyl)amino]benzoic acid | 4-[3-(5-Bromo-2-propoxy-phenyl)...
  8. Semaglutide, Agonist of GLP-1 receptor
    CAS: 910463-68-2 EC Number: 691-729-9 Formula: C187H291N45O59 Molecular Weight: 4113.58
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S304954
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    IUPAC Name
    18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-show more
    SMILES
    CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(CC3=CC=CCshow more
    InChIKey
    DLSWIYLPEUIQAV-CCUURXOWSA-N
    InChI
    1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228show more
    Synonyms
    semaglutidum | NN 9535 | EX-A2424 | SEMAGLUTIDE COMPONENT OF NN1535 ICOSEMA | Ozempic | Rybelsus (oral semaglutide) |...
  9. Bay 55-9837 TFA , Agonist of PAC 1 receptor;Agonist of VPAC 1 receptor;Agonist of VPAC 2 receptor
    CAS: 463930-25-8 PubChem CID: 72941824 Formula: C167H270N52O46• XCF3COOH Molecular Weight: 3742.29(free basis)
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: B288002
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    IUPAC Name
    (3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-aminshow more
    SMILES
    CCC(C)C(C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CO)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=Oshow more
    InChIKey
    NHMJBXFCQMBYCP-ZBLLYJRDSA-N
    InChI
    1S/C167H270N52O46/c1-16-86(10)131(162(263)201-105(39-24-29-63-172)145(246)208-117(74-125(176)229)153(254)197-103(37-22-27-61-170)140(241)196-107(41-31show more
    Synonyms
    UNII-SQD60KZ8RJ | His-ser-asp-ala-val-phe-thr-asp-asn-tyr-thr-arg-leu-arg-lys-gln-val-ala-ala-lys-lys-tyr-leu-gln-ser...
  10. GLP-1(7-36), amide TFA
    CAS: 107444-51-9(free) Formula: C149H226N40O45 Molecular Weight: 3297.68
    ● In Stock — US warehouse, ships to EU* Item #: G488919
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    Synonyms
    Glucagon-Like Peptide 1 (7-36) Amide trifluoroacetate salt
  11. GLP-1 (7-37), Agonist of GLP-1 receptor
    CAS: 106612-94-6 PubChem CID: 16133830 Formula: C151H228N40O47 Molecular Weight: 3355.71
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: G287230
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    Technical Identifiers
    SMILES
    [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@show more
    InChIKey
    GCYXWQUSHADNBF-AAEALURTSA-N
    Synonyms
    1450806-98-0 | AKOS025142102 | GLP-1 (7-37) | DTXSID50147676 | GLP-1(7-37) Acetate | GLP-1(7-37) acetate(106612-94-6 ...
  12. Adomeglivant, Antagonist of glukagon receptor
    CAS: 1488363-78-5 Formula: C32H36F3NO4 Molecular Weight: 555.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A421743
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    IUPAC Name
    3-[[4-[(1S)-1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid
    SMILES
    CC1=CC(=CC(=C1C2=CC=C(C=C2)C(C)(C)C)C)OC(CCC(F)(F)F)C3=CC=C(C=C3)C(=O)NCCC(=O)O
    InChIKey
    FASLTMSUPQDLIB-MHZLTWQESA-N
    InChI
    1S/C32H36F3NO4/c1-20-18-26(19-21(2)29(20)23-10-12-25(13-11-23)31(3,4)5)40-27(14-16-32(33,34)35)22-6-8-24(9-7-22)30(39)36-17-15-28(37)38/h6-13,18-19,27show more
    Synonyms
    F85410 | AKOS040741049 | FASLTMSUPQDLIB-MHZLTWQESA-N | A858152 | ADOMEGLIVANT [WHO-DD] | .BETA.-ALANINE, N-(4-((1S)-1...
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Frequently Asked Questions

How is the GCGR listing put together?
It draws on reported GCGR annotations within GPCR/G Protein and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a GCGR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the GCGR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for GCGR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For GCGR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the GCGR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of GCGR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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