CB1151 - ≥95% , CAS No.182369-28-4

CAS: 182369-28-4 Cat. No.: C651867 Molecular Weight: 446.66 PubChem CID: 78357862

GRADE & PURITY ≥95%

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC 50 value of 0.82 nM

In Vitro

CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [ 3 H]-thymidine incorporation, exhibits an IC 50 value of 0.82 nM. CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC 50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC 50 =3.2nM) in MCF-7 cells transfected with the CAT reporter. CB1151 shows a functional dissociation constant (K df ) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by K df , this is different from that of the traditional dissociation constant (K d ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MCF-7 cell Concentration: 0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM Incubation Time: 5 days Result: Inhibits MCF-7 cells growth.

Form:Solid

IC50& Target:IC50: 0.82 nM

Specifications

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

CB1151 is a 20-epi analogue of 1, 25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC 50 value of 0.82 nM.

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CCC(CC)(CCOC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)O
• IUPAC Name: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(3-ethyl-3-hydroxypentoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• InChIKey: MJTTZPJXKAGWID-BSGGSXJLSA-N
• INCHI: 1S/C28H46O4/c1-6-28(31,7-2)15-16-32-20(4)24-12-13-25-21(9-8-14-27(24,25)5)10-11-22-17-23(29)18-26(30)19(22)3/h10-11,20,23-26,29-31H,3,6-9,12-18H2,1-2,4-5H3/b21-10+,22-11-/t20-,23-,24-,25+,26+,27-/m1/s1
• PubChem CID: 78357862
• Molecular Weight: 446.66

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (223.88 mM; Need ultrasonic)