Cephaloridine hydrate - ≥99% , CAS No.102039-86-1

CAS: 102039-86-1 Cat. No.: C648634 Formula: C₁₉H₁₉N₃O₅S₂ Molecular Weight: 415.49 PubChem CID: 51063108

GRADE & PURITY ≥99%

Synonyms

Cephaloridine monohydrate | (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrate | SCHEMBL7845737 | HY-B2072A | DTXSID30679667 | Cephaloridine (hydrate)

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity.

In Vitro

Cephaloridine hydrate can inhibit Staphylococcus aureus penicillin-sensitive strains, penicillin-resistant strains, Streptococcus pyogenes , Streptococcus pneumoniae , Corynebacterium diphtheriae , Clostridium septicum , and so on, with MICs of 0.05-1 μg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cephaloridine hydrate (50-500 mg/kg; i.m.) exhibits dose-related nephrotoxicity in rabbits and monkeys. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Synonyms

Cephaloridine monohydrate | (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrate | SCHEMBL7845737 | HY-B2072A | DTXSID30679667 | Cephaloridine (hydrate)

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic . Cephaloridine has certain dose-related nephrotoxicity.

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Canonical Smiles

C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4.O

IUPAC Name

(6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrate

InChIKey

KZYZSCXFERELNV-KQKCUOLZSA-N

INCHI

1S/C19H17N3O4S2.H2O/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21;/h1-8,15,18H,9-11H2,(H-,20,23,25,26);1H2/t15-,18-;/m1./s1

Isomeric SMILES

C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4.O

PubChem CID

51063108

Molecular Weight

415.49

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Lactams
      • Subclass Beta lactams
        • Level5 Cephems
          • Level6 Cephalosporins

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Lactams
• Subclass: Beta lactams
• Intermediate Tree Nodes: Cephems
• Direct Parent: Cephalosporins
• Alternative Parents: N-acyl-alpha amino acids and derivatives 1,3-thiazines Pyridinium derivatives Thiophenes Tertiary carboxylic acid amides Heteroaromatic compounds Amino acids Azetidines Carboxylic acid salts Tertiary amines Secondary carboxylic acid amides Thiohemiaminal derivatives Dialkylthioethers Carboxylic acids Azacyclic compounds Monocarboxylic acids and derivatives Hydrocarbon derivatives Carbonyl compounds Organic oxides Organic salts Organic zwitterions
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Cephalosporin - N-acyl-alpha amino acid or derivatives - Alpha-amino acid or derivatives - Meta-thiazine - Pyridine - Pyridinium - Heteroaromatic compound - Thiophene - Tertiary carboxylic acid amide - Amino acid or derivatives - Amino acid - Azetidine - Carboxamide group - Carboxylic acid salt - Tertiary amine - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Carboxylic acid - Dialkylthioether - Monocarboxylic acid or derivatives - Hemithioaminal - Thioether - Amine - Organic salt - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Organic zwitterion - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: H2O : 125 mg/mL (288.35 mM; ultrasonic and warming and heat to 60°C)