Compstatin TFA - ≥99% , CAS No.C659076
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SKU
C659076
Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibit
Appearance:Solid
In Vitro:Compstatin exhibits an in vitro half-life in human blood of about 2 hr. In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster. MCE ha
In Vivo:Compstatin (21mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arteri
Biological Activity:Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibit
More Information
| CAS | C659076 |
|---|---|
| Specifications & Purity | ≥99% |
| Storage | Protected from light,Desiccated,Store at -80°C |
| Shipped In | Dry ice packs + Cold packs |
| Product Description | Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibit Appearance:Solid In Vitro:Compstatin exhibits an in vitro half-life in human blood of about 2 hr. In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster. MCE ha In Vivo:Compstatin (21mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arteri Biological Activity:Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibit |
| Solubility | DMSO : 110 mg/mL (66.07 mM; Need ultrasonic) H2O : 50 mg/mL (30.03 mM; Need ultrasonic) |
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