Cortagine - ≥99% , CAS No.C658697

CAS: C658697 Cat. No.: C658697 Molecular Weight: 4442.06

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an EC 50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive agent in the mouse model.

Appearance:Solid

IC50& Target:CRFR1

In Vitro:Cortagine inhibits rCRF1 (EC 50 =0.18 nM) and mCRF 2β (EC 50 =16 nM) in transfected HEK-293 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice. MCE has not independently confirmed the accur

Biological Activity:Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an EC 50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive agent in the mouse model.

Specifications

Specifications & Purity

≥99%

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥99%

Names and Identifiers

• Molecular Weight: 4442.06

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (11.26 mM; Need ultrasonic)