Cortisone acetate - 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.50-04-4, Glucocorticoid receptor agonist

CAS: 50-04-4 Cat. No.: C408661 Formula: C₂₃H₃₀O₆ Molecular Weight: 402.48 EC Number: 200-006-5

GRADE & PURITY 10mM in DMSO

Synonyms

NSC 49420 | 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 49420 | 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Product Properties

• ALogP: 2.1

Names and Identifiers

• Isomeric SMILES: CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
• Molecular Weight: 402.48
• Reaxy-Rn: 1897065
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1897065&ln=

Chemical and Physical Properties

• Melt Point(°C): 237-240 °C

References

1. Lingna Xu, Ren-ai Xu, Dan Zhang, Shanshan Su, Hanyan Xu, Qing Wu, Yuping Li.  (2023)  The changes of expressive levels of IL-17A, STAT3 and RORγt in different invasive pulmonary aspergillosis mice.  Infection and Drug Resistance,      [PMID:30214252] [10.2147/IDR.S172949]

2. Yangjie LI, Jiaying HUANG, Jihui FANG, Zhiye HUANG.  (2022)  [Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry]..  Chinese Journal of Chromatography,  40  (5): (433-442).  [PMID:35478002] [10.3724/sp.j.1123.2021.09010]

3. Yuan Huang, Zhiqun Zheng, Liying Huang, Hong Yao, Xiao shan Wu, Shaoguang Li, Dandan Lin.  (2017)  Optimization of dispersive liquid-phase microextraction based on solidified floating organic drop combined with high-performance liquid chromatography for the analysis of glucocorticoid residues in food.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:28259095] [10.1016/j.jpba.2017.02.026]

4. Qiyue Zhang, Guanglin Li, Yanmei Wang, Chen Yang, Wenhui Bai, Qingqing Li, Jiye Zhang, Peipei Zhang.  (2025)  Cas5 Regulates the Exposure of β-Glucan, the Cell Surface Hydrophobicity, and the Expression of Cell Wall Proteins to Remodel the Candida albicans Cell Wall and Participates in the Recruitment of Neutrophils.  Microorganisms,  13  (3): (683).  [PMID:40142575] [10.3390/microorganisms13030683]

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 50-04-4, the molecular formula is C23H30O6, and the molecular weight is 402.48 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.