Curcumol - 10mM in DMSO , CAS No.4871-97-0

CAS: 4871-97-0 Cat. No.: C408087 Formula: C₁₅H₂₄O₂ Molecular Weight: 236.35

GRADE & PURITY 10mM in DMSO

Synonyms

6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,3aS,5S,6R,8aS)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
In vitro

Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in Curcumol-induced apoptosis. Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. It attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Synonyms

6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,3aS,5S,6R,8aS)-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Isomeric SMILES

C[C@H]1CC[C@@H]2[C@]13C[C@H]([C@](O3)(CC2=C)O)C(C)C

Molecular Weight

236.35

Reaxy-Rn

2111893

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2111893&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 45 mg/mL (200.7 mM); Water: 45 mg/mL (200.7 mM); Ethanol: 20 mg/mL (89.2 mM)