CVN424 - 10mM in DMSO , CAS No.2254706-21-1

CAS: 2254706-21-1 Cat. No.: C656045 Formula: C₂₄H₂₉F₂N₅O₃ Molecular Weight: 473.52 EC Number: 192-146-8 PubChem CID: 137359492

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CVN424 is an orally active and selective GPR6 inverse agonist with a K i of 9.4 nM and an EC 50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research

In Vitro

CVN424 (Compound 6i) has 265 fold and 68 fold selectivities over GPR3 and GPR12. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 9.4 nM (GPR6), EC50: 38 nM (GPR6)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

CVN424 is an orally active and selective GPR6 inverse agonist with a K i of 9.4 nM and an EC 50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Isomeric SMILES

CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@@H]5CCOC5

Alternate CAS

2254706-21-1

PubChem CID

137359492

Molecular Weight

473.52

Associated Targets(Human)

GPR6 Tchem G-protein coupled receptor 6 (4 Activities)

Discover Target: GPR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)