Cyclophosphamide - Moligand™, ≥95% , CAS No.50-18-0

CAS: 50-18-0 Cat. No.: C1371431 Molecular Weight: 261.09 EC Number: 200-015-4

GRADE & PURITY Moligand™, ≥95%

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Specifications & Purity

Moligand™, ≥95%

Biochemical and Physiological Mechanisms

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.Alkylating agent; pro-drug capable of inducing DNA single-strand breaks . Efficacious in vitro and in vivo .

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: C1CNP(=O)(OC1)N(CCCl)CCCl
• IUPAC Name: N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
• InChIKey: CMSMOCZEIVJLDB-UHFFFAOYSA-N
• INCHI: 1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
• Isomeric SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 261.09
• Reaxy-Rn: 11744
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11744&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Nitrogen mustard compounds

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Nitrogen mustard compounds
• Intermediate Tree Nodes: Not available
• Direct Parent: Nitrogen mustard compounds
• Alternative Parents: Phosphoric monoester diamides Oxazaphosphinanes Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organochlorides Organic oxides Hydrocarbon derivatives Alkyl chlorides
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Nitrogen mustard - Phosphoric monoester diamide - Organic phosphoric acid derivative - Oxazaphosphinane - Organic phosphoric acid amide - Oxacycle - Organoheterocyclic compound - Azacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organochloride - Organopnictogen compound - Organohalogen compound - Organic oxygen compound - Alkyl chloride - Alkyl halide - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as nitrogen mustard compounds. These are compounds having two beta-haloalkyl groups bound to a nitrogen atom.
• External Descriptors: organochlorine compound - nitrogen mustard - phosphorodiamide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: 25°C: DMSO 52mg/mL; Water 43 mg/mL; Ethanol 52 mg/mL
• Melt Point(°C): 49.2-52.8°C
• Molecular Weight: 261.079 g/mol
• XLogP3: 0.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 260.025 Da
• Monoisotopic Mass: 260.025 Da
• Topological Polar Surface Area: 41.600 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 212.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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60. Tian Liu, Jinming Luo, Xiaoyang Meng, Liming Yang, Bin Liang, Meijun Liu, Chengbin Liu, Aijie Wang, Xia Liu, Yong Pei, Jili Yuan, John Crittenden.  (2018)  Electrocatalytic dechlorination of halogenated antibiotics via synergistic effect of chlorine-cobalt bond and atomic H*.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:29990817] [10.1016/j.jhazmat.2018.06.064]

61. Kai Yin, Lin Deng, Jinming Luo, John Crittenden, Chengbin Liu, Yuanfeng Wei, Longlu Wang.  (2018)  Destruction of phenicol antibiotics using the UV/H2O2 process: Kinetics, byproducts, toxicity evaluation and trichloromethane formation potential.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2018.06.164]

62. Zeng Dongping, Sun Meizhen, Lin Zhoumeng, Li Miao, Gehring Ronette, Zeng Zhenling.  (2018)  Pharmacokinetics and Pharmacodynamics of Tildipirosin Against Pasteurella multocida in a Murine Lung Infection Model.  Frontiers in Microbiology,      [PMID:29867911] [10.3389/fmicb.2018.01038]

63. Jiangdong Dai, Sujun Tian, Yinhua Jiang, Zhongshuai Chang, Atian Xie, Ruilong Zhang, Chunxiang Li, Yongsheng Yan.  (2018)  Fe3C/Fe/C Magnetic Hierarchical Porous Carbon with Micromesopores for Highly Efficient Chloramphenicol Adsorption: Magnetization, Graphitization, and Adsorption Properties Investigation.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.7b05300]

64. Jiangdong Dai, Sujun Tian, Yinhua Jiang, Zhongshuai Chang, Atian Xie, Ruilong Zhang, Yongsheng Yan.  (2017)  Facile synthesis of porous carbon sheets from potassium acetate via in-situ template and self-activation for highly efficient chloramphenicol removal.  JOURNAL OF ALLOYS AND COMPOUNDS,      [PMID:] [10.1016/j.jallcom.2017.10.237]

65. Xue Liu, Zhen Cao, Zilin Yuan, Jing Zhang, Xingpan Guo, Yi Yang, Feng He, Yaping Zhao, Jiang Xu.  (2017)  Insight into the kinetics and mechanism of removal of aqueous chlorinated nitroaromatic antibiotic chloramphenicol by nanoscale zero-valent iron.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2017.10.060]

66. Liu Xia, Sun Ju, Duan Shengxia, Wang Yanan, Hayat Tasawar, Alsaedi Ahmed, Wang Chengming, Li Jiaxing.  (2017)  A Valuable Biochar from Poplar Catkins with High Adsorption Capacity for Both Organic Pollutants and Inorganic Heavy Metal Ions.  Scientific Reports,  7  (1): (1-12).  [PMID:28855653] [10.1038/s41598-017-09446-0]

67. Bo Zheng, Fengwei Xie, Wenbei Situ, Ling Chen, Xiaoxi Li.  (2017)  Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2017.07.048]

68. Sujun Tian, Jiangdong Dai, Yinhua Jiang, Zhongshuai Chang, Atian Xie, Jinsong He, Ruilong Zhang, Yongsheng Yan.  (2017)  Facile preparation of intercrossed-stacked porous carbon originated from potassium citrate and their highly effective adsorption performance for chloramphenicol.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:28672265] [10.1016/j.jcis.2017.06.062]

69. Zhou Jia-heng, Chen Kai-bo, Hong Qian-kun, Zeng Fan-cheng, Wang Hong-yu.  (2017)  Degradation of chloramphenicol by potassium ferrate (VI) oxidation: kinetics and products.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  24  (11): (10166-10171).  [PMID:28258432] [10.1007/s11356-017-8656-7]

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71. Qu Ying, Qiu Zhenzhen, Cao Changfu, Lu Yan, Sun Meizhen, Liang Chaoping, Zeng Zhenling.  (2015)  Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model.  BMC Veterinary Research,  11  (1): (1-7).  [PMID:26631082] [10.1186/s12917-015-0608-1]

72. Chu Wenhai, Chu Tengfei, Du Erdeng, Yang Deng, Guo Yingqing, Gao Naiyun.  (2015)  Increased formation of halomethanes during chlorination of chloramphenicol in drinking water by UV irradiation, persulfate oxidation, and combined UV/persulfate pre-treatments.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:26513530] [10.1016/j.ecoenv.2015.10.016]

73. Naifeng Xu, Liguang Xu, Wei Ma, Liqiang Liu, Hua Kuang, Chuanlai Xu.  (2015)  An ultrasensitive immunochromatographic assay for non-pretreatment monitoring of chloramphenicol in raw milk.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2014.998640]

74. Naifeng Xu, Liguang Xu, Wei Ma, Hua Kuang, Chuanlai Xu.  (2015)  Development and characterisation of an ultrasensitive monoclonal antibody for chloramphenicol.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2014.950201]

75. J. Li, Y. Hu, Q. Zhang, B. Ma, Z. Wu, Y. Wang, J. Sun, J. Zhu, H. Ying, P. Ouyang.  (2014)  Strontium fructose 1, 6-diphosphate alleviate cyclophosphamide-induced oligozoospermia by improving antioxidant and inhibiting testicular apoptosis via FAS/FASL pathway.  ANDROLOGIA,  47  (9): (995-1003).  [PMID:25382543] [10.1111/and.12369]

76. Chen Qing-quan, Han Xuesong, Wang Wan-ming, Zhao Liangyu, Chen Aimin.  (2014)  Danggui Sini Decoction Ameliorates Myelosuppression in Animal Model by Upregulating Thrombopoietin Expression.  CELL BIOCHEMISTRY AND BIOPHYSICS,  71  (2): (945-950).  [PMID:25308860] [10.1007/s12013-014-0291-z]

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78. Xiaojiao Du, Xingyu Ji, Jingyu Hong, Jiahao Shao, Ruijie Shi, Qiuyi Lu, Xiaoyan Jiang, Jun Sun.  (2024)  A mediator and spatial-resolution induced dual-ratiometric self-powered photoelectrochemical aptasensor for accurate detection of antibiotics.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.113929]

79. Yuan Gao, Jun Wang, Weiwei Zhang, Fei Ge, Wanzhen Li, Feiyang Xu, Ting Cui, Xing Li, Kai Yang, Yugui Tao.  (2024)  Application of capsaicin and calcium phosphate-loaded MOF system for tumor therapy involving calcium overload.  Nanomedicine-Nanotechnology Biology and Medicine,      [PMID:38851440] [10.1016/j.nano.2024.102759]

80. Zheng Rongji, Guan Tian, Hong Chaoqun, Yao Yao, Fang Yutong, Huang Wei, Chen Chunfa, Zeng Huancheng, Huang Jiman, Lin Hui, Chen Bingfeng, Zhang Rendong, Chen Dongmei, Ding Zhechun, Zeng Haoyu, Wu Jundong.  (2024)  C188-9 reduces patient-specific primary breast cancer cells proliferation at the low, clinic-relevant concentration.  Journal of Translational Medicine,  22  (1): (1-9).  [PMID:39174945] [10.1186/s12967-024-05542-8]

81. Shuai Zhao, Chenglong Lin, Meimei Xu, Weida Zhang, Dan Li, Yusi Peng, Zhengren Huang, Yong Yang.  (2024)  Comprehensive SERS–LFIA Platform for Ultrasensitive Detection and Automated Discrimination of Chloramphenicol Residues in Aquatic Products.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.4c03280]

82. Xiaotian Guan, Jingru Zhao, Zhou Sha, Yujie Liang, Jianghong Huang, Jun Zhang, Shuqing Sun.  (2024)  CRISPR/Cas12a and aptamer-chemiluminescence based analysis for the relative abundance determination of tumor-related protein positive exosomes for breast cancer diagnosis.  BIOSENSORS & BIOELECTRONICS,      [PMID:38754193] [10.1016/j.bios.2024.116380]

83. Shuang Zhang, Dongling Wu, Qian Liu, Yunpeng Shen, Tao Wang.  (2025)  Deep eutectic solvent induced silver-gel as a flexible SERS substrate for sensitive detection of antibiotics under low temperature conditions.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39864195] [10.1016/j.jhazmat.2025.137279]

84. Weiyan Li, Chuansheng Sun, Haiping Wang, Qingyan Bai, Yi Xu, Chunmiao Bo, Junjie Ou.  (2024)  Detection and adsorption of florfenicol in milk using bifunctional carbon dot–doped molecularly imprinted polymers.  ELECTROPHORESIS,      [PMID:39034741] [10.1002/elps.202400053]

85. Yahui Jia, Zhiqiang Zhang, Siming Zhang, Xia Ma, Yuan Ruan, Bingji Ma, Li Wang.  (2024)  Effects of polysaccharide from hot-compressed steamed Rehmannia glutinosa on the immune system and gut microbiota in an immunosuppressed mice model.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:39303540] [10.1016/j.intimp.2024.113202]

86. XinQian Rong, QingLong Shu.  (2024)  Enhancing immunomodulation in cyclophosphamide-induced immunosuppressed mice through targeted modulation of butyrate-producing gut microbiota via oral administration of astragalus polysaccharides.  Food Science & Nutrition,      [PMID:39479666] [10.1002/fsn3.4386]

87. Binbin Yao, Yin Lu, Anna Li, Lan Ma, Wenlong Wang, Kai Wu, Yuefei Ji, Feng Zhu, Jing Chen, Junhe Lu.  (2024)  Ferrate(Ⅵ) oxidative degradation of capecitabine in aquatic matrices: Degradation performance, mechanisms, and toxicity assessment.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.114535]

88. Qian Zhou, Kunpeng Li, Kun Wang, Weilin Hong, Jingjie Chen, Jin Chai, Luofeng Yu, Zhangyong Si, Peng Li.  (2024)  Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance.  Science Advances,  10  (35):   [PMID:39196947] [10.1126/sciadv.adp6604]

89. Xu He, Xiuhong Peng, Suyu Zhang, Tianfeng Yang, Jian Huo, Yanmin Zhang.  (2024)  Hepatoprotective effect of diammonium glycyrrhizinate and neuroprotective effect of piperazine ferulate on AmB-induced liver and kidney injury by suppressing apoptosis in vitro and in vivo.  TOXICON,      [PMID:38849008] [10.1016/j.toxicon.2024.107795]

90. Qing-Hua Xiao, Wu-Ye Li, Jin Zhang, Jia-Min Yu, Dong-Yang Liu, Jiang-Nan Peng, Mao-Ye Li, Su Liu.  (2024)  Knockdown of the cap ‘n’ collar isoform C gene increases the susceptibility of Agrotis ipsilon to chlorantraniliprole and phoxim.  JOURNAL OF ASIA-PACIFIC ENTOMOLOGY,      [PMID:] [10.1016/j.aspen.2024.102244]

91. Ying Yang, Mengfan Luo, Wanyi Zhou, Wenyang Tao, Jingrui Li, Jianrong Xing, Quanqin Tan, Yuxing Guo.  (2024)  Lactiplantibacillus plantarum YY-112 ameliorates mouse immunosuppression by enhancing B/T-cell activation and maintaining Th1/Th2 homeostasis.  Food Frontiers,      [PMID:] [10.1002/fft2.477]

92. Keyang Lai, Jun Xu, Kai Luo, Min Xie, Yuan Chen, Fan Li, Yaomin Zhou, Lihui Gong, Yonghua Xiong, Weihua Lai.  (2024)  Lateral flow immunoassay based on aggregation induced emission nanobeads for the sensitive and accurate detection of chloramphenicol in pig hair.  ANALYTICAL BIOCHEMISTRY,      [PMID:39608623] [10.1016/j.ab.2024.115728]

93. Guohao Mu, Fang Peng, Ziyin Zhang, John M. Brameld, Peter Rose, Xiaogang Yang, Zhi-jiang Jiang, Xi He, Bencan Tang.  (2024)  Magnolol-loaded polydopamine-chitosan coated pH-responsive nanoparticles for alleviation of ulcerative colitis.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2024.106151]

94. XinQian Rong, QingLong Shu.  (2024)  Modulating butyric acid-producing bacterial community abundance and structure in the intestine of immunocompromised mice with neutral polysaccharides extracted from Codonopsis pilosula.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39179083] [10.1016/j.ijbiomac.2024.134959]

95. Ruiyu Fu, Xiaoqin Hai, Qingxin Lu, Hongbo Li, Jiaxiao Niu, Yanhui Zhang, Tingze Ren, Xiaoli Guo, Xin Di.  (2024)  Molecularly imprinted polymer gel with superior recognition and adsorption capacity for amphenicol antibiotics in food matrices.  FOOD CHEMISTRY,      [PMID:39303467] [10.1016/j.foodchem.2024.141255]

96. Yijing Ai, Behisht Ara, Baoli Wang, Mansoor Ahmad, Xiao Han, Lisi Wang, Shuhai He, Ruifeng Li, Wei Sun.  (2025)  One step laser-induced Fe3O4 loaded 3D graphene electrode for electrochemical sensing and supercapacitor applications.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.112776]

97. Jing Song, Shanshan Zhang, Junya Xing, Licong Zhang, Jiajun Wang, Anshan Shan.  (2024)  Optimizing therapeutic efficacy of antifungal peptides via strategic terminal amino acid modification.  Journal of Advanced Research,      [PMID:39322048] [10.1016/j.jare.2024.09.017]

98. Jinjia Zhang, Junhong Li, Yongqiang Hou, Yao Lin, Hao Zhao, Yiran Shi, Kaiyun Chen, Cheng Nian, Jiayu Tang, Lei Pan, Yunzhi Xing, Huan Gao, Bingying Yang, Zengfang Song, Yao Cheng, Yue Liu, Min Sun, Yueyue Linghu, Jiaxin Li, Haitao Huang, Zhangjian Lai, Zhien Zhou, Zifeng Li, Xiufeng Sun, Qinghua Chen, Dongxue Su, Wengang Li, Zhihai Peng, Pingguo Liu, Wei Chen, Hongling Huang, Yixin Chen, Bailong Xiao, Lilin Ye, Lanfen Chen, Dawang Zhou.  (2024)  Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor.  CELL,      [PMID:38744281] [10.1016/j.cell.2024.04.023]

99. Cheng Zhen, Li Wang, Yanru Feng, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang.  (2024)  Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans.  Advanced Science,      [PMID:38995235] [10.1002/advs.202406473]

100. Zhengwei Xiong, Cun Wang, Cheng Liu, Yue Jiang, Yiping Li, Wen Yun.  (2024)  Sensitive fluorescence assay of chloramphenicol coupled with two-level isothermal amplification using a self-powered catalyzed hairpin assembly and entropy-driven circuit.  Analytical Methods,  16  (21): (3430-3437).  [PMID:38766841] [10.1039/D4AY00641K]

101. Yaozhong Lv, Yajun Yang, Ying Chen, Dongfan Wang, Yipeng Lei, Mingyue Pan, Zhenzhong Wang, Wei Xiao, Yujie Dai.  (2024)  Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Poria cocos.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38309394] [10.1016/j.ijbiomac.2024.129878]

102. Xinru Du, Yongheng Yan, Yufeng Dai, Ruijie Xu.  (2024)  Yogurt Alleviates Cyclophosphamide-Induced Immunosuppression in Mice through D-Lactate.  Nutrients,  16  (9): (1395).  [PMID:38732641] [10.3390/nu16091395]

103. Jinxingyi Wang, Ruyu Tao, Hanshuai Hu, Xue Lan, Jiejie Gao, Yanping Guan, Qian Liu.  (2025)  Therapeutic drug monitoring of busulfan and cyclophosphamide in hematologic malignancies: An LC-MS/MS development, validation and application.  JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS,      [PMID:40759333] [10.1016/j.vascn.2025.108389]

104. Dan Wan, Xihong Zhou, Chunyan Xie, Xugang Shu, Xin Wu, Yulong Yin.  (2015)  Toxicological evaluation of ferrous N-carbamylglycinate chelate: Acute, Sub-acute toxicity and mutagenicity.  REGULATORY TOXICOLOGY AND PHARMACOLOGY,      [PMID:26364753] [10.1016/j.yrtph.2015.09.013]

105. Kai-Jie Hu, Wen-Hui Gu, Yan Zhou, Jing Chen.  (2025)  A stable hydrogen-bonded organic framework (HOF) for selective fluorescence sensing of neomycin sulphate.  INORGANICA CHIMICA ACTA,      [PMID:] [10.1016/j.ica.2025.122709]

106. Tongtong Ma, Qiao Huang, Lei Yuan, Shugang Yan, Yalin Mo, Yibin Ying, Yingchun Fu, Jinming Pan.  (2025)  Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics.  Advanced Science,      [PMID:40285681] [10.1002/advs.202502452]

107. Chen Yang, Guoqing He, Shukun Zhao, Shanpeng Dong, Yantong Liu, Yifan Wang, Tao Jiang, Yihan Ma, Longfei Chen, Xiaotong Si, Shilun Feng, Xuan Xiao, Yi Yang.  (2025)  Probe-free and wash-free strategy for on-site testing of chloramphenicol in food based on differential encodable microspheres separation system.  TALANTA,      [PMID:40359682] [10.1016/j.talanta.2025.128250]

108. Liming Xie, Guanfeng Chen, Qianqian Ouyang, Weiyan Quan, Xiaoming Xie, Xiaoling Chen, Lefan Li, Sidong Li, Rizhi Chen, Rongqiong Luo, Zhiqing Qiu.  (2025)  A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance.  Frontiers in Pharmacology,      [PMID:40351407] [10.3389/fphar.2025.1579771]

109. Yufang Chen, Zhenhua Yan, Pengpeng Su, Shiqi Liu, Xi Chen, Runren Jiang, Guanghua Lu, Saiyu Yuan.  (2025)  Remediation strategy of biochar with different addition approaches on antibiotic resistance genes in riparian zones under dry wet alternation.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40215939] [10.1016/j.jhazmat.2025.138207]

110. Fanghang Li, Jing Tian, Yezhu Xu, Wenting Yi, Qiang Chen, Jiteng Wang, Su Jiang, Yunping Tang, Tao Han.  (2025)  Physicochemical characteristics and therapeutic mechanisms of Sargassum horneri-derived soluble dietary fiber in cyclophosphamide-induced intestinal damage via gut microbiota and metabolic modulation.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106996]

111. Yang Ji-Feng, You Deng, Zheng Li-Ying, Zhang Jin-Yang, Deng Lin, Luo Shen-Lian.  (2025)  Mechanism and Degradation Pathways of Chloramphenicol via FeSe2-Catalyzed Peroxymonosulfate Activation.  CATALYSIS LETTERS,  155  (7): (1-15).  [PMID:] [10.1007/s10562-025-05086-6]

112. Guangyuan Yang, Xiaojia Niu, Tian Zhuang, Xiaoxiao Zhu, Qianwen Xu, Hongchen Wang, Jing Shao, Changzhong Wang, Yue Yang, Tianming Wang, Wenfan Wei, Daqiang Wu.  (2025)  Mitochondrial anchor protein Num11 is key to pathogenicity of Candida albicans by affecting mitochondrial function and cell wall masking.  Virulence,      [PMID:40531863] [10.1080/21505594.2025.2519149]

113. Xinyue Liang, Weihong Zhang, Xiaolong Yao, Zhengyang Feng, Qingwei Bu, Wenwen Gong, Wei Wang, Chun Wang, Yingxue Sun.  (2025)  Investigation of adsorption-electrochemical degradation properties of Cu-doped ZIF-8/MWCNTs/CC anode materials against emerging organochlorine contaminants in wastewater.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.119774]

114. Li Wang, Yupeng Yang, Xuelian Tang, Chunnan Wen, Zhiqiang Zhang, Xia Ma, Bingji Ma.  (2025)  Effects of polysaccharides from Stropharia rugosoannulata on cyclophosphamide-induced immunosuppression and hepatic injury in mice.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:41195471] [10.1002/jsfa.70295]

115. Zhaoyuan He, Chengxiang Fu, Shuling Meng, Jiaqi Luo, Jieke Qiu, Jianing Huang, Xiaoge Duan, Jiakang He, Jinzi Wang, Hailan Chen.  (2025)  Electrochemical aptasensor based on Zr-MOF@Ag nanocomposite for the rapid detection of chloramphenicol in honey, milk and lake water.  FOOD CHEMISTRY,      [PMID:41275550] [10.1016/j.foodchem.2025.147213]

116. Yun-Fei Shao, Jia-Min Yu, Jia-Qi Xing, Wang-Xi Shen, Min-Feng Yang, Mao-Ye Li, Su Liu.  (2025)  Knockdown of AisHSP19.6 by RNA Interference Increases Susceptibility to Three Insecticides in Agrotis ipsilon.  ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY,  120  (3): (e70114).  [PMID:41252628] [10.1002/arch.70114]

117. Like Li, Yi Li, Guohong Zou, Lu Cai, Maoqing Chen, Xiaoming Chen, Bo Han, Ya-nan Zhang, Yong Zhao.  (2025)  High-sensitivity and high-specificity optical fiber SPR doxorubicin sensor enabled by Ti3C2 MXene sensitization.  TALANTA,      [PMID:41330132] [10.1016/j.talanta.2025.129156]

118. Shiqiong Xiang, Yang Chen, Jiayue Xia, Guiju Sun.  (2025)  Purification, Structural Characterization, and Immunomodulatory Activities of a Glucan from Morchella sextelata.  Foods,  15  (1): (105).  [PMID:41517171] [10.3390/foods15010105]

119. Cangcang Zhang, Dinghui Wang, Yang Shan, Chenggui Miao, Changzhong Wang, Weifan Wei, Tianming Wang, Jian Wang, Daqiang Wu.  (2026)  Decoding the mechanism: Sodium houttuyfonate's impact on macrophage M2 polarization and inflammation.  MICROBIAL PATHOGENESIS,      [PMID:41619993] [10.1016/j.micpath.2026.108336]

120. Sitao Wang, Yi Yang, Xiaoqing Shi, Rong Fan, Yujie Ding, Juan Wu, Zhigang Xu.  (2026)  Post-imprinting modification of molecularly imprinted polymers for ultrasensitive screening chloramphenicol type antibiotics and risk assessment in urban environmental water.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:41747701] [10.1016/j.jhazmat.2026.141611]

121. Su Dehui, Ma Ruiqiong, Su Huina, Tan Cheng, Zhu Ye, Liu Yanhua, Jiang Xiaolin, Sun Xiaowan, Lei Tonghao, Zhang Mengyu, Lin Shengrui, Qi Yongfen, Yang Xin.  (2026)  Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway.  npj Aging,      [PMID:41839900] [10.1038/s41514-026-00359-9]

122. Bo Li, Lin Zhang, Ding-Tao Wu, Qin Yuan, Shengpeng Wang, Mao-Ling Tan, Mei-Lin Feng, Yi-Chen Hu, Liang Zou, Zi-Peng Wang, Ya-Nan Cao, Jing-Wei Huang.  (2026)  Potential structure-immunostimulatory activity relationship of Tartary buckwheat sprout pectic polysaccharides: Influences of molecular mass and esterification degree.  FOOD RESEARCH INTERNATIONAL,      [PMID:] [10.1016/j.foodres.2026.118949]

123. Lele Zhou, Lingbin Chen, Cailin Zheng, Jinneng Wu, Meihua Zhong, Zhixiong Huang, Zhiming Xin, Zhou Chen.  (2026)  Tripchlorolide-induced reversible impairment of male fertility and the involvement of PI3K/Akt/mTOR signaling.  TOXICOLOGY LETTERS,      [PMID:] [10.1016/j.toxlet.2026.111872]