Cytochalasin J - ≥95% , CAS No.53760-20-6

CAS: 53760-20-6 Cat. No.: C329406 Formula: C₂₈H₃₇NO₄ Molecular Weight: 451.6 EC Number: 637-306-4 PubChem CID: 102239810

GRADE & PURITY ≥95%

Synonyms

(1R,2R,3Z,5R,7S,9Z,11R,12S,14S,15R,16S)-16-benzyl-2,5,12-trihydroxy-5,7,14-trimethyl-13-methylidene-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-18-one | Cytochalasin j

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Cytochalasin J is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin J is the deacetyl analogue of cytochalasin H and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumor activities.

Application：

Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research

Specifications

Synonyms

(1R,2R,3Z,5R,7S,9Z,11R,12S,14S,15R,16S)-16-benzyl-2,5,12-trihydroxy-5,7,14-trimethyl-13-methylidene-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-18-one | Cytochalasin j

Specifications & Purity

≥95%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Cytochalasins are regarded as highly toxic and possible teratogens. Handle in a manner to avoid/minimize direct body contact and inhalation.

Purity

≥95%

Names and Identifiers

Pubchem Sid

488202606

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488202606

Canonical Smiles

CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1)(C)O)O)C(=O)NC3CC4=CC=CC=C4)C)O

IUPAC Name

(1R,2R,3Z,5R,7S,9Z,11R,12S,14S,15R,16S)-16-benzyl-2,5,12-trihydroxy-5,7,14-trimethyl-13-methylidene-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-18-one

InChIKey

UKQNIEMKORIOQM-RVVPKKHWSA-N

INCHI

1S/C28H37NO4/c1-17-9-8-12-21-25(31)19(3)18(2)24-22(15-20-10-6-5-7-11-20)29-26(32)28(21,24)23(30)13-14-27(4,33)16-17/h5-8,10-14,17-18,21-25,30-31,33H,3,9,15-16H2,1-2,4H3,(H,29,32)/b12-8-,14-13-/t17-,18+,21-,22-,23+,24-,25+,27-,28+/m0/s1

Isomeric SMILES

C[C@H]1C/C=C\[C@H]2[C@@H](C(=C)[C@H]([C@@H]3[C@@]2([C@@H](/C=C\[C@](C1)(C)O)O)C(=O)N[C@H]3CC4=CC=CC=C4)C)O

WGK Germany

3

PubChem CID

102239810

Molecular Weight

451.6

Chemical and Physical Properties

• Solubility: Soluble in ethanol, methanol, DMF, DMSO, and water (poorly).
• Sensitivity: Light sensitive
• Refractive Index: n20D1.61 (Predicted)
• Boil Point(°C): 679.51° C at 760 mmHg (Predicted)
• Melt Point(°C): 137-139° C