Deoxyelephantopin - 10mM in DMSO , CAS No.29307-03-7

CAS: 29307-03-7 Cat. No.: D655688 Molecular Weight: 344.4

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber , has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB , MAPK , PI3K/Akt , and β-catenin signaling

In Vitro

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC 50 s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively. Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NF-κB

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber , has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB , MAPK , PI3K/Akt , and β-catenin signaling.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC2C(C(CC3=CC(C1)OC3=O)OC(=O)C(=C)C)C(=C)C(=O)O2
• Molecular Weight: 344.4
• Reaxy-Rn: 25965389
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25965389&ln=