Dinotefuran(MTI-446) - ≥98%, used for Dinotefuran has been used as a standard for the determination of neonicotinoid insecticide residues in dietary bee pollen and melon samples by HPLC–MS/MS and high performance liquid chromatography coupled with ultravi

CAS: 165252-70-0 Cat. No.: D135549 Molecular Weight: 202.21 EC Number: 605-399-0
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
MTI-446 | DTXCID5014549 | AS-30705 | DTXSID7034549 | 3-[(4-CHLOROPHENYL)THIO]-2-METHYLPROPANOICACID | AKOS015919619 | (E)-dinotefuran | 1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine | NCGC00255236-01 | CAS-165252-70-0 | CHEBI:39184 | Tox21_30
Storage
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1g
D135549-1g
3
$10.90
5g
D135549-5g
7
$19.90
25g
D135549-25g
2
$69.90
100g
D135549-100g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$186.90
500g
D135549-500g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$711.90
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Protected from light,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 36 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
MTI-446 | DTXCID5014549 | AS-30705 | DTXSID7034549 | 3-[(4-CHLOROPHENYL)THIO]-2-METHYLPROPANOICACID | AKOS015919619 | (E)-dinotefuran | 1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine | NCGC00255236-01 | CAS-165252-70-0 | CHEBI:39184 | Tox21_30
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Dinotefuran is a competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [3H]epibatidine in the neural cord memb
Application
Dinotefuran has been used as a standard for the determination of neonicotinoid insecticide residues in dietary bee pollen and melon samples by HPLC–MS/MS and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UVD), respectively
Storage
Store at 2-8°C, Protected from light, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Isomeric SMILES CN/C(=N\[N+](=O)[O-])/NCC1CCOC1
WGK Germany 3
Molecular Weight 202.21

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
G2423067Certificate of AnalysisMay 09, 2026 D135549
G2423157Certificate of AnalysisMay 09, 2026 D135549
F2222352Certificate of AnalysisJan 20, 2026 D135549
F2222353Certificate of AnalysisJan 20, 2026 D135549
A2605073Certificate of AnalysisOct 13, 2025 D135549
E2622059Certificate of AnalysisOct 13, 2025 D135549
F2605160Certificate of AnalysisOct 13, 2025 D135549
J2509079Certificate of AnalysisOct 13, 2025 D135549
J2527037Certificate of AnalysisOct 13, 2025 D135549
F2222350Certificate of AnalysisMar 10, 2025 D135549
F2222349Certificate of AnalysisApr 03, 2024 D135549
K2426093Certificate of AnalysisApr 03, 2024 D135549
F2222351Certificate of AnalysisJun 07, 2022 D135549
G2326073Certificate of AnalysisJun 07, 2022 D135549
J2323064Certificate of AnalysisJun 07, 2022 D135549

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Chemical and Physical Properties
SensitivityLight sensitive;Air sensitive; Heat sensitive
Melt Point(°C)106 °C
Molecular Weight202.210 g/mol
XLogP30.100
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass202.107 Da
Monoisotopic Mass202.107 Da
Topological Polar Surface Area91.500 Ų
Heavy Atom Count14
Formal Charge0
Complexity225.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Citations of This Product
References
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2. Weiwei Yuan, Shuhuai Li, Xionghui Ma, Chaohai Pang, Yuwei Wu, Mingyue Wang, Bei Li.  (2023)  MOF@Au NPs/aptamer fluorescent probe for the selective and sensitive detection of thiamethoxam.  LUMINESCENCE,  39  (2): (e4651).  [PMID:38104966] [10.1002/bio.4651]
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5. Ying Shi, Saier Wang, Man Xu, Xinli Yan, Junbiao Huang, Hong-wei Wang.  (2022)  Removal of neonicotinoid pesticides by adsorption on modified Tenebrio molitor frass biochar: Kinetics and mechanism.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2022.121506]
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7. Lei Liu, Jiawei Guo, Longhua Ding.  (2021)  Polyaniline Nanowire Arrays Deposited on Porous Carbon Derived from Raffia for Electrochemical Detection of Imidacloprid.  ELECTROANALYSIS,  33  (9): (2048-2052).  [PMID:] [10.1002/elan.202100162]
8. Xiaoqing Li, Mingxia Zhang, Yong Li, Xiangyang Yu, Jinfang Nie.  (2020)  Effect of neonicotinoid dinotefuran on root exudates of Brassica rapa var. chinensis.  CHEMOSPHERE,      [PMID:33248730] [10.1016/j.chemosphere.2020.129020]
9. Yong Li, Ling Long, Huangqian Yan, Jing Ge, Jinjin Cheng, Liyun Ren, Xiangyang Yu.  (2018)  Comparison of uptake, translocation and accumulation of several neonicotinoids in komatsuna (Brassica rapa var. perviridis) from contaminated soils.  CHEMOSPHERE,      [PMID:29510368] [10.1016/j.chemosphere.2018.02.104]
10. Lijuan Zhao, Juan Yang, Huili Ye, Faqiong Zhao, Baizhao Zeng.  (2017)  Preparation of hydrophilic surface-imprinted ionic liquid polymer on multi-walled carbon nanotubes for the sensitive electrochemical determination of imidacloprid.  RSC Advances,  (8): (4704-4709).  [PMID:] [10.1039/C6RA25969C]
11. Pei Xiu, Bai Jinchuan, Li Yaming, Kong Xiangbo.  (2024)  A Fluorescent Nanoplatform Based on Tb3+@tartric Acid-Functionalized UiO-67-bpy: A New Strategy of Synergistic Sensitization and its Highly Sensitive Performance toward the Detection of Nitenpyram.  Journal of Inorganic and Organometallic Polymers and Materials,      [PMID:] [10.1007/s10904-024-03420-w]
12. Quanxin Zhang, Pingfan Xu, Nana Yan, Yujing Ren, Xujun Liang, Xuetao Guo.  (2024)  Adsorption of neonicotinoid insecticides by mulch film-derived microplastics and their combined toxicity.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39490386] [10.1016/j.scitotenv.2024.177238]
13. Pengxi Li, Wangjing Zhai, Qiqi Guo, Xuanyu Zou, Yujue Wang, Yucheng Gu, Xueke Liu, Zhiqiang Zhou, Peng Wang, Donghui Liu.  (2024)  Effects of ammonium sulfate on the degradation and metabolism of dinotefuran in soil: Evidence from soil physicochemical properties and bacterial community structure.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39368503] [10.1016/j.scitotenv.2024.176674]
14. Hong Sun, Xinyu Li, Xinyue Yuan, Zhen Tian, Yifan Li, Yalin Zhang, Jiyuan Liu.  (2024)  Elucidating the detoxification efficacy of Periplaneta americana delta glutathione S-transferase 1 (PaGSTd1) against organophosphates.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:39084777] [10.1016/j.pestbp.2024.106013]
15. Luyang Liu, Xuanyue Yu, Yuting Huang, Cuiting Liu, Xinyi Xie, Zhongzhen Wu, Jintian Lin, Benshui Shu.  (2024)  Exposure to Sublethal Concentrations of Dinotefuran Induces Apoptosis in the Gut of Diaphorina citri Adults via Activating the Mitochondrial Apoptotic Pathway.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39178008] [10.1021/acs.jafc.4c06081]
16. Xin Liu, Shiyue Niu, Bin Yang, Jia Liu, Liqian Niu, Xian Wang, Daqian Song, Shuyun Bi.  (2025)  Fabrication of BSA-protected AgNPs modified MIL-53(Al) as SERS substrate for trace determination of diquat and dipterex.  TALANTA,      [PMID:40154046] [10.1016/j.talanta.2025.128002]
17. Lingyun Fan, Jia Wang, Chen Wang, Xujia Zhang, Qi Li, Hanxi Wang, Yi Liu, Yuan Hui Zhao, Shuying Zang.  (2024)  Photolysis of dinotefuran and nitenpyram in water and ice phase: Influence mechanism of temperature over photolysis.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:39151370] [10.1016/j.ecoenv.2024.116895]
18. Yimeng Shi, Yan Zhu, Jiaojiao Sun, Huancai Yin, Jian Yin.  (2024)  SERS detection of thiram using a 3D sea cucumber-like composite flexible porous substrate.  ANALYST,      [PMID:39193646] [10.1039/D4AN00610K]
19. Bin Yang, Jia Liu, Xin Liu, Shiyue Niu, Liqian Niu, Xian Wang, Xinxin Liu, Shuyun Bi.  (2025)  SERS methods for detecting acetamiprid and pymetrozine in fruits using the substrate of CuO-protected silver nanoparticles modified with β-cyclodextrin.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113382]
20. Jiayao Fan, Huimin Pan, Chenyang Yuan, Tianyuan Liu, Feng Shang, Yuxi Zhou, Yifan Gao, Long Yi, Jinjun Wang, Wei Dou.  (2025)  The relationship between the Huanglongbing pathogen and Diaphorina citri with body color polyphenism: field dynamics, acquisition efficiency, and immunity response.  PEST MANAGEMENT SCIENCE,      [PMID:40028791] [10.1002/ps.8743]
21. Caicai Liu, Ran Li, Peng Yun, Fuzun Chen, Yu-E Shi, Xiaobo Zhu, Zhenguang Wang.  (2025)  Room-Temperature Phosphorescence Sensor Array for Detection and Discrimination of Neonicotinoid Insecticides based on Host-Guest Doping.  ANALYST,      [PMID:40686059] [10.1039/D5AN00521C]
22. Haoming Guo, Nan Xiao, Yabo Liang, Xueke Liu, Peng Wang, Donghui Liu.  (2025)  Neurotoxic impacts of neonicotinoid pesticide residues in Chinese honey on Apis mellifera L..  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:40879281] [10.1002/jsfa.70154]
23. Qiang Tan, Zhonglin Chen, Jimin Shen, Pengwei Yan, Jing Kang, Binyuan Wang, Shengxin Zhao, Yang Shen, Yabin Li.  (2025)  In situ construction of ZnFe-layered double oxides on biochar for improving interfacial adsorption-catalysis of ozone achieves efficient water purification.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.135358]
24. Linlin Liu, Min Shi, Yanyan Wu, Jiali Hao, Junxiu Guo, Shanshan Li, Pingli Dai, Jing Gao.  (2025)  Protective effects of resveratrol on honeybee health: Mitigating pesticide-induced oxidative stress and enhancing detoxification.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:40262860] [10.1016/j.pestbp.2025.106403]
25. Yunshuo Chen, Yachan Gong, Dan Li, Weiwei Feng, Yao Chen, Ting Zhao, Liuqing Yang, Guanghua Mao, Xiangyang Wu.  (2025)  Dinotefuran exposure induces immunotoxicity in zebrafish embryos.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:40222697] [10.1016/j.cbpc.2025.110206]
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34. Liqian Niu, Xian Wang, Xinxin Liu, Xin Liu, Shiyue Niu, Bin Yang, Jia Liu, Shuyun Bi.  (2026)  Construction of the SERS substrate of AgNPs modified with N-Acetyl-L-cysteine and ZnO for sensitive detection of acephate.  JOURNAL OF LUMINESCENCE,      [PMID:] [10.1016/j.jlumin.2026.121796]
35. Jiawei Lei, Yushan Li, Mingxin Bai, Haoyue Du, Xueqin Shen, Hu Fu, Zhengli Yan, Yongfei Zhu.  (2026)  Dinotefuran induces BNIP3/NIX-mitophagy, necroptosis, and damage in the uterus of adolescent mice.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:] [10.1016/j.pestbp.2026.107077]
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