Dioscin - Moligand™, 10mM in DMSO , Antagonist of CXCR3, CAS No.19057-60-4, Antagonist of CXCR3

CAS: 19057-60-4 Cat. No.: D408362 Molecular Weight: 869.05 EC Number: 866-819-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Collettiside III, Saponin | β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.
In vitro

Dioscin is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. Dioscin induces apotosis in Hela cells by down regulating caspase-8 activity and up regulating caspase-9 activity.

In vivo

LD50: Mice >300mg/kg
Cell Data

cell lines：Mesangial cells

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Synonyms

Collettiside III, Saponin | β-D-Glucopyranoside, (3β, 25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of CXCR3

Names and Identifiers

• Isomeric SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1
• Alternate CAS: 19057-60-4
• MeSH Entry Terms: dioscin
• Molecular Weight: 869.05
• Reaxy-Rn: 42293031
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=42293031&ln=

Associated Targets(Human)

CXCR3 Tchem C-X-C chemokine receptor type 3 (1 Activities)

Discover Target: CXCR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo.  (2020)  Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation.  AUTOIMMUNITY,      [PMID:33274645] [10.1080/08916934.2020.1855428]

2. Qiuyue Ding, Wenda Zhang, Cheng Cheng, Fengbo Mo, Lei Chen, Guangfu Peng, Xianyi Cai, Jinglong Wang, Shuhua Yang, Xianzhe Liu.  (2019)  Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo.  JOURNAL OF CELLULAR PHYSIOLOGY,  235  (3): (2911-2924).  [PMID:31535374] [10.1002/jcp.29197]

3. Weixin Zhang, Lianhong Yin, Xufeng Tao, Lina Xu, Lingli Zheng, Xu Han, Youwei Xu, Changyuan Wang, Jinyong Peng.  (2016)  Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,      [PMID:27317992] [10.1016/j.etap.2016.06.002]

4. Meng Zhang, Deyuan Zhi, Pei Liu, Yajun Wang, Meili Duan.  (2024)  Protective effects of Dioscin against sepsis-induced cardiomyopathy via regulation of toll-like receptor 4/MyD88/p65 signal pathway.  Immunity Inflammation and Disease,  12  (5): (e1229).  [PMID:38775678] [10.1002/iid3.1229]

5. Doudou Lu, Ling Yuan, Xiaoyan Ma, Fandi Meng, Duojie Xu, Shumin Jia, Zhaozhao Wang, Yahong Li, Zhe Zhang, Yi Nan.  (2024)  The mechanism of polyphyllin in the treatment of gastric cancer was verified based on network pharmacology and experimental validation.  Heliyon,      [PMID:38831826] [10.1016/j.heliyon.2024.e31452]

6. Doudou Lu, Ling Yuan, Zhaozhao Wang, Duojie Xu, Fandi Meng, Shumin Jia, Yahong Li, Weiqiang Li, Yi Nan.  (2025)  Dioscin induces ferroptosis to suppress the metastasis of gastric cancer through the SLC7A11/GPX4 axis.  FREE RADICAL RESEARCH,      [PMID:40460255] [10.1080/10715762.2025.2515202]