≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
An HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
Application：
DK-AH 269 has been used as a hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) antagonist to study its effects on the inhibition of Ih in HCN-deficient hair cells of mice.It has also been used as an HCN blocker to study its effects on action potential firing in the suprachiasmatic nucleus (SCN) neurons
| Canonical Smiles | COC1=C(C=C(C=C1)CCN2CCCC(C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC.Cl |
|---|---|
| IUPAC Name | 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride |
| InChIKey | MTAKUIYCCYKGJJ-BOXHHOBZSA-N |
| INCHI | 1S/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31;/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3;1H/t21-;/m0./s1 |
| Isomeric SMILES | COC1=C(C=C(C=C1)CCN2CCC[C@@H](C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC.Cl |
| WGK Germany | 3 |
| Alternate CAS | 147541-45-5 |
| Molecular Weight | 519.07 |
| Reaxy-Rn | 10509461 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10509461&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Benzazepines |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzazepines |
| Alternative Parents | Dimethoxybenzenes Phenethylamines Phenoxy compounds Anisoles Alkyl aryl ethers Aralkylamines Azepines Piperidines Tertiary carboxylic acid amides Trialkylamines Lactams Amino acids and derivatives Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Hydrochlorides Organic oxides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Benzazepine - Dimethoxybenzene - O-dimethoxybenzene - Phenethylamine - Anisole - Phenoxy compound - Phenol ether - Methoxybenzene - Alkyl aryl ether - Azepine - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Piperidine - Tertiary carboxylic acid amide - Tertiary aliphatic amine - Carboxamide group - Lactam - Amino acid or derivatives - Tertiary amine - Ether - Carboxylic acid derivative - Azacycle - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Organonitrogen compound - Organooxygen compound - Amine - Organic oxide - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ring fused to an azepine ring (unsaturated seven-membered heterocycle with one nitrogen atom replacing a carbon atom). |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2423267 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423269 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423271 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423274 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423276 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423278 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423280 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423282 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423285 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| E2423286 | Certificate of Analysis | Jan 24, 2024 | D350697 |
| Solubility | Soluble in water (20 mg/ml). |
|---|---|
| Sensitivity | Moisture Sensitive |
| Molecular Weight | 519.100 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 9 |
| Exact Mass | 518.255 Da |
| Monoisotopic Mass | 518.255 Da |
| Topological Polar Surface Area | 60.500 Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 663.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
