DMT1 blocker 2 - ≥99% , CAS No.1062648-63-8

CAS: 1062648-63-8 Cat. No.: D651447 Formula: C₁₆H₁₃N₃O Molecular Weight: 263.29

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo

In Vitro

DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells. DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage: 50 mg/kg Administration: Oral gavage followed 1 h later by an iron challenge Result: Attenuated the post-challenge serum iron increase.

Form:Solid

IC50& Target:IC50: 0.83 μM (divalent metal transporter 1)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Molecular Weight

263.29

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (189.90 mM; Need ultrasonic)