DN02 - ≥99% , CAS No.D658743

CAS: D658743 Cat. No.: D658743 Formula: C₂₂H₂₄FN₃O₃ Molecular Weight: 397.44

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8(1) ( K i =32 nM), which is 30-fold more affinity than BRD8 (2) ( K i ＞1000 nM).

Appearance:Solid

In Vitro:DN02 has (1 nM-100 μM) low nM AlphaScreen with IC 50 value of 48 nM, with high selectivity over BRD9 and BRD4 in biochemical AlphaScreen assays. DN02 (32 nM) has minimal off-target engagement across the bromodomain family, with modest activity agains

Biological Activity:DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8(1) ( K i =32 nM), which is 30-fold more affinity than BRD8 (2) ( K i ＞1000 nM).

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Molecular Weight

397.44