DRB18 - ≥98% , CAS No.D414435

CAS: D414435 Cat. No.: D414435 Formula: C₂₂H₂₃ClN₂O₂ Molecular Weight: 382.88

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

DRB18 DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

Targets

GLUT

In vitro

DRB18 inhibits growth and proliferation in about 90% of the 60 different cancer cell lines in 9 major cancer types. DRB18 treatment leads to significant changes in glucose-based metabolism in A549 lung cancer cells, including cell death via ER/oxidative stress and necrosis.

In vivo

DRB18 (10 mg/kg) treatment thrice a week significantly reduces growth in Xenograft A549 tumors.

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Product Properties

• ALogP: 5.767
• HBD Count: 4
• Rotatable Bond: 6

Names and Identifiers

• Canonical Smiles: CC1=CC=C(CNC2=C(NCC3=CC(=C(C)C=C3)O)C=C(Cl)C=C2)C=C1O
• Molecular Weight: 382.88
• Reaxy-Rn: 36374407
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36374407&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 76 mg/mL (198.49 mM); Ethanol: 76 mg/mL (198.49 mM); Water: Insoluble
• DMSO(mg / mL) Max Solubility: 76
• DMSO(mM) Max Solubility: 198.495612202257
• Water(mg / mL) Max Solubility: ＜1

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is D414435, the molecular formula is C22H23ClN2O2, and the molecular weight is 382.88 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.