MW 2000 Da for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 26 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
DSPE PEG Amine (DSPE-PEG-NH2) is one of reactive phospholipid PEG reagents that have a reactive primary amine group on one PEG terminus. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine) is a saturated 18C phospholipid commonly used in liposome synthesis. Polyethylene glycol (PEG) conjugated DSPE has both hydrophilicity and hydrophobility property that is useful for drug delivery, gene transfection and biomolecule modification. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. Amine functionalized DSPE PEG allows further modification of PEG lipid via its reactive amino group.
Application：
DSPE-PEG-NH2 is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an amine. DSPE-PEG-NH2 is used to modify liposome surface with biomolecules containing amine reactive groups (NHS, thiolate). It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.
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