DSPE PEG, mPEG-DSPE - MW 5000 Da , CAS No.147867-65-0

CAS: 147867-65-0 Cat. No.: D163638

GRADE & PURITY MW 5000 Da

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

228,229

Overview

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated Polyethylene Glycol, DSPE PEG is a phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Specifications

Specifications & Purity

MW 5000 Da

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCCCCCC.[Na+]
• IUPAC Name: sodium;[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate
• InChIKey: SRLOHQKOADWDBV-NRONOFSHSA-M
• INCHI: 1S/C45H88NO11P.Na/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-43(47)54-40-42(41-56-58(50,51)55-37-36-46-45(49)53-39-38-52-3)57-44(48)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;/h42H,4-41H2,1-3H3,(H,46,49)(H,50,51);/q;+1/p-1/t42-;/m1./s1
• Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCCCCCC.[Na+]
• Reaxy-Rn: 60733557
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=60733557&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Glycerophospholipids
      • Subclass Glycerophosphoethanolamines
        • Level5 Glycero-3-phospho-N-acyl-ethanolamines
          • Level6 N-acyl-phosphatidylethanolamines

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Glycerophospholipids
• Subclass: Glycerophosphoethanolamines
• Intermediate Tree Nodes: Glycero-3-phospho-N-acyl-ethanolamines
• Direct Parent: N-acyl-phosphatidylethanolamines
• Alternative Parents: Phosphoethanolamines Fatty acid esters Dialkyl phosphates Dicarboxylic acids and derivatives Carbamate esters Carboxylic acid esters Dialkyl ethers Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds Organic cations
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: N-acyl-phosphatidylethanolamine - Phosphoethanolamine - Fatty acid ester - Dialkyl phosphate - Dicarboxylic acid or derivatives - Organic phosphoric acid derivative - Phosphoric acid ester - Fatty acyl - Alkyl phosphate - Carbamic acid ester - Carboxylic acid ester - Organic alkali metal salt - Ether - Dialkyl ether - Carboxylic acid derivative - Organic salt - Organic sodium salt - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organic cation - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as n-acyl-phosphatidylethanolamines. These are phosphatidylethanolamines with a N-acylated ethanolamine moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Off-white/white solid or semi-solid depends on molecule weight;Soluble in warm water and chloroform
• Sensitivity: Light & Moisture & Heat sensitive
• Molecular Weight: 872.100 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 48
• Exact Mass: 871.591 Da
• Monoisotopic Mass: 871.591 Da
• Topological Polar Surface Area: 159.000 Ų
• Heavy Atom Count: 59
• Formal Charge: 0
• Complexity: 994.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Zhenhu Guo, Xiaohan Gao, Jingsong Lu, Ying Li, Zeping Jin, Abdul Fahad, Neema Ufurahi Pambe, Hirotaka Ejima, Xiaodan Sun, Xiumei Wang, Wensheng Xie, Guifeng Zhang, Lingyun Zhao.  (2024)  Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment.  ACS Nano,      [PMID:38377439] [10.1021/acsnano.3c10173]

2. Beibei Zhang, Hao Liu, Yifei Wang, Yong Zhang.  (2024)  ROS-Responsive and Self-Catalytic Nanocarriers for a Combination of Chemotherapy and Reinforced Ferroptosis against Breast Cancer.  ACS Biomaterials Science & Engineering,      [PMID:39262329] [10.1021/acsbiomaterials.4c01233]

3. Yang Qihao, Wu Jianqun, Huang Songqiang, Zeng Jing, Jing Yihan, Wang Zhiyong, Zhang Chi, Wu Zenghui, Liu Song, Wang Zhao.  (2025)  Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing the NF-κB p65/CD44 signaling pathway and attenuates osteoarthritis.  EXPERIMENTAL AND MOLECULAR MEDICINE,      [PMID:40887495] [10.1038/s12276-025-01529-7]

4. Fangxue Du, Hongxin Zhao, Ruiqian Guo, Jianbo Huang, Ziyan Feng, Ziyao Wang, Li Qiu.  (2025)  Nature-based nanothylakoids for reshaped tumor microenvironment-assisted robust sonodynamic immunotherapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171503]