Duloxetine HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.136434-34-9, Norepinephrine transporter inhibitor

CAS: 136434-34-9 Cat. No.: D407972 Formula: C₁₈H₁₉NOS · HCl Molecular Weight: 333.88 EC Number: 603-962-5

GRADE & PURITY 10mM in DMSO

Synonyms

LY-248686 HCl | (γS)​-N-​methyl-​γ-​(1-​naphthalenyloxy)​-2-​thiophenepropanamine, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Duloxetine HCl Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with K i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
In vitro

In vivo

Cell Data

cell lines：CAL-62 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

LY-248686 HCl | (γS)​-N-​methyl-​γ-​(1-​naphthalenyloxy)​-2-​thiophenepropanamine, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Norepinephrine transporter inhibitor

Names and Identifiers

Isomeric SMILES

CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl

WGK Germany

3

RTECS

XN0258000

Alternate CAS

116817-13-1

Molecular Weight

333.88

Reaxy-Rn

13592284

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13592284&ln=

Chemical and Physical Properties

• Refractive Index: 122° (C=1,MeOH)
• Specific Rotation[α]: 122° (C=1,MeOH)
• Melt Point(°C): 164℃