Edratide - ≥98% , CAS No.433922-67-9

CAS: 433922-67-9 Cat. No.: E650377 Formula: C₁₁₁H₁₄₉N₂₇O₂₈ Molecular Weight: 2309.53 PubChem CID: 16214485

GRADE & PURITY ≥98%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis ( Apoptosis ) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

In Vivo

Edratide (20-50 µg; s.c.; once a week for 10 weeks) exerts beneficial effects on SLE is through regulation of gene expression. Edratide (50 μg/mouse; s.c.; 10 weekly) reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL in SLE mouse. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-7 months female mice (with established SLE)Dosage: 20-50 µg Administration: Subcutaneously injection; once a week for 10 weeks Result: Up-regulated the RNA transcripts of Tnfsf4, Il5ra, Zbtb20, Nid1, down-regulated the transcripts of Tfpi and S100a8. Animal Model: 7-8 months SLE-afflicted BWF1 female miceDosage: 50 μg/mouse Administration: S.c.; 10 weekly Result: Reduced apoptosis, down-regulated caspase-8 and caspase-3, and up-regulated Bcl-xL.

Form:Solid

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis ( Apoptosis ) and dow

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CO)NC(=O)[C@H](CC7=CNC8=CC=CC=C87)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)CN

PubChem CID

16214485

Molecular Weight

2309.53

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (43.30 mM; Need ultrasonic)
• Molecular Weight: 2309.500 g/mol
• XLogP3: -4.900
• Hydrogen Bond Donor Count: 31
• Hydrogen Bond Acceptor Count: 31
• Rotatable Bond Count: 68
• Exact Mass: 2309.11 Da
• Monoisotopic Mass: 2308.11 Da
• Topological Polar Surface Area: 883.000 Ų
• Heavy Atom Count: 166
• Formal Charge: 0
• Complexity: 5190.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 17
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1