EGFR-IN-1 TFA - ≥99% , CAS No.E659035

CAS: E659035 Cat. No.: E659035 Formula: C₃₀H₃₁F₃N₆O₆ Molecular Weight: 628.6

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR . EGFR-IN-1 TFA displays strong antiprolife

Appearance:Solid

IC50& Target:EGFR L858R/T790M

In Vitro:EGFR-IN-1 TFA (compound 24) is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 TFA displays stron

In Vivo:EGFR-IN-1 TFA (30mg/kg; p.o.; daily for 2 weeks) displays significant tumor growth inhibition with no observed loss in body weight. EGFR-IN-1 TFA evaluates in a time course PD experiment upon oral dosing at 30mg/kg. EGFR-IN-1 TFA shows a >50% inhib

Biological Activity:EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR . EGFR-IN-1 TFA displays strong antiprolife

Specifications

Specifications & Purity

≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Molecular Weight

628.6

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (397.71 mM; Need ultrasonic)