Emlenoflast sodium - ≥98% , CAS No.2380032-29-9

CAS: 2380032-29-9 Cat. No.: E651047 Molecular Weight: 410.47 PubChem CID: 155971211

GRADE & PURITY ≥98%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome , with an IC 50 of <100 nM. Emlenoflast sodium can be used for the research of inflammatory diseases

In Vitro

Emlenoflast, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC 50 of <100 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Emlenoflast (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC 0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice. ?\nEmlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), C max (60467 ng/mL) and half-life (5.02 h) in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6 mice (7-9 weeks)Dosage: 4 mg/kg for i.v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis) Administration: A single intravenousbolus or oral gavage Result: I.v.: t 1/2 =3.39 h; AUC 0-last =107097 ng•h/mL; CL=0.621 mL/min/kg. P.o.: F=67.2%; C max =60467 ng/mL; t 1/2 =5.02 h.

Form:Solid

IC50& Target:NLRP3 inflammasome <100 nM (IC 50 )

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome , with an IC 50 of <100 nM. Emlenoflast sodium can be used for the research of inflammatory diseases.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(C)N1C=CC(=N1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4.[Na+]
• IUPAC Name: sodium;1,2,3,5,6,7-hexahydro-s-indacen-4-ylcarbamoyl-(1-propan-2-ylpyrazol-3-yl)sulfonylazanide
• InChIKey: RKEFKQUKINZXDR-UHFFFAOYSA-M
• INCHI: 1S/C19H24N4O3S.Na/c1-12(2)23-10-9-17(21-23)27(25,26)22-19(24)20-18-15-7-3-5-13(15)11-14-6-4-8-16(14)18;/h9-12H,3-8H2,1-2H3,(H2,20,22,24);/q;+1/p-1
• PubChem CID: 155971211
• Molecular Weight: 410.47

Chemical and Physical Properties

• Solubility: DMSO : 240 mg/mL (584.70 mM; Need ultrasonic)