Ethyl trifluoroacetate - ≥99% , CAS No.383-63-1

CAS: 383-63-1 Cat. No.: E105562 Molecular Weight: 142.08 Beilstein Registry Number: 1761411 EC Number: 206-851-6
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Synonyms
UNII-A6TZK6X11X | CF3CO2Et | SCHEMBL60813 | STK260851 | Trifluoroacetic acid, ethyl ester | FT-0625798 | AS-14040 | ethyl trifluoracetate | AI3-52221 | ETHYL TRIFLUOROACETATE | ethyl tri-fluoroacetate | Acetic acid, trifluoro-, ethyl ester | CF3COOC2H5 |
Storage
Room temperature,Argon charged
Shipped In
FedEx DG Service
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25g
E105562-25g
2
$11.90
100g
E105562-100g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$19.90
250g
E105562-250g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$45.90
500g
E105562-500g
1
$77.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature,Argon charged Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
UNII-A6TZK6X11X | CF3CO2Et | SCHEMBL60813 | STK260851 | Trifluoroacetic acid, ethyl ester | FT-0625798 | AS-14040 | ethyl trifluoracetate | AI3-52221 | ETHYL TRIFLUOROACETATE | ethyl tri-fluoroacetate | Acetic acid, trifluoro-, ethyl ester | CF3COOC2H5 |
Specifications & Purity
≥99%
Storage
Room temperature, Argon charged
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥99%
Names and Identifiers
Pubchem Sid504751868
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504751868
Canonical SmilesCCOC(=O)C(F)(F)F
IUPAC Nameethyl 2,2,2-trifluoroacetate
InChIKeySTSCVKRWJPWALQ-UHFFFAOYSA-N
INCHI1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
Isomeric SMILES CCOC(=O)C(F)(F)F
WGK Germany 1
Alternate CAS 383-63-1
NSC Number 220215
UN Number 1993
Packing Group II
Molecular Weight 142.08
Beilstein 1761411
Reaxy-Rn 1761411
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1761411&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAlpha-halocarboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentAlpha-halocarboxylic acid derivatives
Alternative Parents Carboxylic acid esters  Monocarboxylic acids and derivatives  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Alkyl fluorides  
Molecular FrameworkAliphatic acyclic compounds
Substituents Alpha-halocarboxylic acid derivative - Carboxylic acid ester - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organofluoride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl fluoride - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as alpha-halocarboxylic acid derivatives. These are carboxylic acid derivatives containing a halogen atom bonded to the alpha carbon atom.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

44 results found

Lot NumberCertificate TypeDateItem
H2328428Certificate of AnalysisJun 09, 2026 E105562
H2328426Certificate of AnalysisJun 09, 2026 E105562
C2620302Certificate of AnalysisMar 09, 2026 E105562
C2620301Certificate of AnalysisMar 09, 2026 E105562
C2620263Certificate of AnalysisMar 09, 2026 E105562
C2620226Certificate of AnalysisMar 09, 2026 E105562
J2531112Certificate of AnalysisNov 12, 2025 E105562
G2518339Certificate of AnalysisJul 09, 2025 E105562
G2518343Certificate of AnalysisJul 09, 2025 E105562
G2518342Certificate of AnalysisJul 09, 2025 E105562
G2518341Certificate of AnalysisJul 09, 2025 E105562
G2518340Certificate of AnalysisJul 09, 2025 E105562
H2231500Certificate of AnalysisJun 10, 2025 E105562
H2231447Certificate of AnalysisJun 10, 2025 E105562
A2513125Certificate of AnalysisDec 16, 2024 E105562
A2513126Certificate of AnalysisDec 16, 2024 E105562
A2513329Certificate of AnalysisDec 16, 2024 E105562
A2513330Certificate of AnalysisDec 16, 2024 E105562
A2513124Certificate of AnalysisDec 16, 2024 E105562
J2424590Certificate of AnalysisOct 14, 2024 E105562
J2424589Certificate of AnalysisOct 14, 2024 E105562
J2424588Certificate of AnalysisOct 14, 2024 E105562
J2424587Certificate of AnalysisOct 14, 2024 E105562
J2114522Certificate of AnalysisJul 12, 2024 E105562
J2114523Certificate of AnalysisJul 12, 2024 E105562
G2402323Certificate of AnalysisJun 07, 2024 E105562
G2402321Certificate of AnalysisJun 07, 2024 E105562
G2402322Certificate of AnalysisJun 07, 2024 E105562
G2402320Certificate of AnalysisJun 07, 2024 E105562
G2402319Certificate of AnalysisJun 07, 2024 E105562
C2130105Certificate of AnalysisJan 10, 2024 E105562
C2130104Certificate of AnalysisJan 10, 2024 E105562
H2328429Certificate of AnalysisAug 15, 2023 E105562
H2328427Certificate of AnalysisAug 15, 2023 E105562
E2424056Certificate of AnalysisAug 15, 2023 E105562
G2424055Certificate of AnalysisAug 15, 2023 E105562
C2303434Certificate of AnalysisFeb 03, 2023 E105562
C2303428Certificate of AnalysisFeb 03, 2023 E105562
C2303427Certificate of AnalysisFeb 03, 2023 E105562
H2311050Certificate of AnalysisFeb 03, 2023 E105562
H2231754Certificate of AnalysisJul 03, 2022 E105562
H2231753Certificate of AnalysisJul 03, 2022 E105562
H2231502Certificate of AnalysisJul 03, 2022 E105562
A2516186Certificate of AnalysisSep 08, 2021 E105562

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Chemical and Physical Properties
SolubilitySlightly miscible with water. Miscible with chloroform and methanol.
SensitivityMoisture sensitive.
Refractive Index1.3073
Flash Point(°F)30.2 °F
Flash Point(°C)-1℃
Boil Point(°C)61.7°C
Melt Point(°C)<-78°C
Molecular Weight142.080 g/mol
XLogP31.200
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass142.024 Da
Monoisotopic Mass142.024 Da
Topological Polar Surface Area26.300 Ų
Heavy Atom Count9
Formal Charge0
Complexity107.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Futing Yang, Wenjie Yu, Qiying Yu, Xiyu Liu, Chunping Liu, Chong Lu, Xinghua Liao, Yi Liu, Na Peng.  (2023)  Mitochondria-Targeted Nanosystem with Reactive Oxygen Species-Controlled Release of CO to Enhance Photodynamic Therapy of PCN-224 by Sensitizing Ferroptosis.  Small,  19  (16): (2206124).  [PMID:36693788] [10.1002/smll.202206124]
2. Huan Xu, Mingyue Yang, Yijing Du, Tian Gao, Yi Liu, Liwei Xiong, Na Peng.  (2022)  Self-assembly of micelles with pH/ROS dual-responsiveness and mitochondrial targeting for potential anti-tumor applications.  NEW JOURNAL OF CHEMISTRY,  46  (44): (21235-21244).  [PMID:] [10.1039/D2NJ03244A]
3. Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen.  (2021)  Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release.  Pharmaceutics,  13  (9): (1464).  [PMID:34575539] [10.3390/pharmaceutics13091464]
4. Miaomiao Long, Shenhuan Liu, Xiaotian Shan, Jing Mao, Fuwei Yang, Xiaoyu Wu, Lipeng Qiu, Jinghua Chen.  (2020)  Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2020.101859]
5. Xin Ji, Huilong Guo, Qiao Tang, Dong Ma, Wei Xue.  (2017)  A targeted nanocarrier based on polyspermine for the effective delivery of methotrexate in nasopharyngeal carcinoma.  Materials Science & Engineering C-Materials for Biological Applications,      [PMID:28888001] [10.1016/j.msec.2017.07.036]
6. Zhixian Huang, Ling Li, Miaomiao Zhou, Haiming Jiang, Ting Qiu.  (2015)  Isobaric vapor–liquid equilibrium of trifluoroacetic acid + water, trifluoroacetic acid + ethyl trifluoroacetate and ethyl trifluoroacetate +  ethanol binary mixtures.  FLUID PHASE EQUILIBRIA,      [PMID:] [10.1016/j.fluid.2015.08.012]
7. Tianzhi Yu, Yan Cao, Wenming Su, Chengcheng Zhang, Yuling Zhao, Duowang Fan, Mingjun Huang, Kan Yue, Stephen Z. D. Cheng.  (2013)  Synthesis, structure, photo- and electro-luminescence of an iridium(III) complex with a novel carbazole functionalized β-diketone ligand.  RSC Advances,  (2): (554-562).  [PMID:] [10.1039/C3RA44432E]
8. Chang Hui, Kang Wenjia, Zhao Xinyu, Chang Shuai, Li Xinping, Luo Yuxia, Xiong Chuanyin, Zhu Xunjin, Zhang Zhao.  (2025)  Nanocellulose chiral synergistic effect enhances circularly polarized luminescence of lanthanide electric dipole transition bands.  CELLULOSE,      [PMID:] [10.1007/s10570-025-06473-3]
9. Danying Yi, Tao Wang, Shuangshuang Xu, Yuying Liu, Zhonghao Wang, Ning Li, Ye Wu, Yiyan He.  (2025)  Injectable ROS/pH-Responsive Hydrogel for Synergistic Chemo-Photodynamic Tumor Therapy and Enhanced Wound Healing.  Advanced Healthcare Materials,      [PMID:40798895] [10.1002/adhm.202502349]
10. Ying Hu, Dandan Wang, Qijie Yu, Ziyi He, Fengrui Deng, Hao Yan, Tinglu Song, Jin-Cheng Zheng, Yang Dai.  (2025)  The Use of Cognate Cosolvent to Mediate Localized High-Concentration Electrolytes for High-Voltage and Long-Cycling Lithium-Metal Batteries.  Batteries-Basel,  11  (4): (156).  [PMID:] [10.3390/batteries11040156]
11. Zhaojun Liu, Jiaxuan Feng, Rui Yang, Shen-ao Wang, Xiaochen Wu, Xiangyu Zhang, Sujuan Cheng, Ning Liu, Teng Long, Pengchao Si.  (2025)  Breaking the 5.5 V barrier: Lithium nitrate-stabilized electrolyte for wide-temperature and high-voltage applications.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.170208]
12. Na Peng, Chun Song, Xiaoting Liu, Michał Nowicki, Roman Szewczyk, Yanyang Wang, Yi Liu.  (2025)  Mitochondria-Targeted HA-Coated Nanosystem for ROS/CO Generation and Metabolic Reprogramming to Enhance Tumoricidal Macrophage Polarization.  ACS Applied Materials & Interfaces,      [PMID:41196012] [10.1021/acsami.5c15795]
13. Shichao Zhang, Siyuan Li, Yuezheng Liu, Jin Tang, Xinyang Wang, Wei Zhong, Shulan Mao, Qian Wu, Chaoqiang Tan, Ziren Long, Hao Cheng, Yong Wu, Yingying Lu.  (2026)  Molecular Engineering of Fluorinated Solvents Enables Practical Lithium Metal Batteries.  Advanced Energy Materials,      [PMID:] [10.1002/aenm.202506771]
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