Evenamide - 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.1092977-61-1, Sodium channel alpha subunit blocker

CAS: 1092977-61-1 Cat. No.: E656150 Formula: C₁₆H₂₆N₂O₂ Molecular Weight: 278.39 PubChem CID: 25105689

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker ( K i =0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness

In Vitro

Evenamide selectively blocks voltage-gated sodium channels (VGSCs) in a voltage-and use-dependent manner (K i =0.4 µM) and modulates sustained repetitive firing without inducing impairment of the normal neuronal excitability. Evenamide does not bind, inhibit or interact with over 130 receptors, enzymes, or transporters. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Evenamide is active in a wide range of psychiatric animal models in monotherapy and addon to antipsychotics. Evenamide is effective in attenuating the social interaction deficit in Cl 395 (PCP)-impaired rats (MED=1 mg/kg po). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Sodium channel

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker ( K i =0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Sodium channel alpha subunit blocker

Product Properties

ALogP

2.5

Names and Identifiers

Isomeric SMILES

CCCCOC1=CC=CC(=C1)CCNCC(=O)N(C)C

Alternate CAS

1092977-61-1

PubChem CID

25105689

Molecular Weight

278.39

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1092977-61-1, the molecular formula is C16H26N2O2, and the molecular weight is 278.39 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.