Polyanetholesulfonic Acid Sodium Salt: Key FAQs

Polyanetholesulfonic acid sodium salt is a synthetic anionic polysulfonate polymer widely recognized in research and clinical laboratory settings for its anticoagulant properties and its utility as an additive in blood culture and microbiological media.

Chemical Name

Polyanetholesulfonic acid sodium salt

SKU

P755560

Compound Class

Anionic polysulfonate polymer (synthetic)

Primary Application

Anticoagulant additive in blood culture media and microbiological research

Common Abbreviation

SPS (Sodium Polyanetholesulfonate)

Supplier

Aladdin Scientific

What Is Polyanetholesulfonic Acid Sodium Salt?

Polyanetholesulfonic acid sodium salt, commonly abbreviated as SPS (sodium polyanetholesulfonate), is a synthetic anionic polymer bearing multiple sulfonate groups along its backbone. It is soluble in water and carries a high negative charge density, which underlies many of its biological and chemical activities.

In laboratory practice, SPS is best known as an anticoagulant and anti-complementary agent. It inhibits the coagulation cascade, inactivates certain components of the complement system, and can suppress the activity of some antimicrobial peptides, making it a valuable additive in blood culture systems where preserving microbial viability is essential.

Aladdin Scientific supplies Polyanetholesulfonic acid sodium salt under SKU P755560 to support research applications requiring a reliable, characterized source of this reagent.

Key Applications in Research and Diagnostics

Polyanetholesulfonic acid sodium salt has several well-established applications in biomedical and microbiological research:

• Blood Culture Media Additive: SPS is routinely incorporated into blood culture broths to prevent clotting of the blood sample, neutralize the bactericidal activity of serum, and inhibit complement-mediated killing, thereby improving recovery of microorganisms from clinical or experimental blood samples.
• Anticoagulation in Sample Preparation: When preparing blood or plasma samples for downstream assays, SPS can be used as an alternative or complementary anticoagulant to EDTA or heparin, particularly where interference from those agents is a concern.
• Microbiological Research: SPS is used in growth media formulations to create conditions more permissive to fastidious or slow-growing organisms.
• In Vitro Studies: Researchers employ SPS to study the complement system, coagulation pathways, and host-pathogen interactions under controlled anticoagulated conditions.

Note: Specific concentration recommendations and compatibility data should be verified against published protocols for each application.

Storage, Handling, and Safety Considerations

Proper storage and handling of Polyanetholesulfonic acid sodium salt are important to maintain reagent integrity and ensure laboratory safety:

• Storage: Store the reagent according to the conditions specified on the product label and Certificate of Analysis (CoA). Anionic polysulfonates are generally stable as dry solids when kept in a cool, dry place away from moisture and incompatible substances. Specific temperature requirements should be confirmed from the product CoA.
• Solubility: SPS is water-soluble. Stock solutions should be prepared in suitable aqueous buffers and sterile-filtered if intended for cell culture or microbiological use.
• Safety: As with all laboratory reagents, standard personal protective equipment (PPE) including gloves, lab coat, and eye protection should be worn. Consult the Safety Data Sheet (SDS) for full hazard information before use.
• Shelf Life: Refer to the product label and CoA for lot-specific expiry information. Do not use reagent beyond its stated expiry date.

If you require the SDS or CoA for SKU P755560, please contact Aladdin Scientific customer service.

Ordering and Availability from Aladdin Scientific

Polyanetholesulfonic acid sodium salt is available from Aladdin Scientific under SKU P755560. Researchers and procurement teams can place orders through the following channels:

• Online: Search for SKU P755560 on the Aladdin Scientific website to view current availability, pack sizes, and pricing.
• Customer Service: Contact Aladdin Scientific directly for bulk quotations, custom pack sizes, or expedited delivery requirements.
• Documentation: Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are available upon request or through the product page on the Aladdin Scientific website.

For questions about lead times, minimum order quantities, or institutional pricing, please reach out to the Aladdin Scientific sales team.

Frequently asked questions

What is Polyanetholesulfonic acid sodium salt used for in the laboratory?

Polyanetholesulfonic acid sodium salt (SPS) is primarily used as an anticoagulant and anti-complementary additive in blood culture media, where it prevents clot formation, neutralizes serum bactericidal activity, and inhibits complement-mediated killing to improve microbial recovery. It is also employed in microbiological research media formulations and in vitro studies of coagulation and complement pathways.

How should Polyanetholesulfonic acid sodium salt (SKU P755560) be stored?

The reagent should be stored according to the conditions specified on the product label and Certificate of Analysis (CoA) provided by Aladdin Scientific. Generally, anionic polysulfonate solids are stored in a cool, dry environment away from moisture. Always consult the CoA and SDS for lot-specific storage requirements and shelf-life information.

Is Polyanetholesulfonic acid sodium salt the same as SPS?

Yes. SPS stands for sodium polyanetholesulfonate, which is the commonly used abbreviation for Polyanetholesulfonic acid sodium salt. The two names refer to the same synthetic anionic polysulfonate polymer and are used interchangeably in the scientific literature and product catalogs.

Can SPS be used as an alternative to heparin or EDTA for anticoagulation?

SPS can serve as an anticoagulant in certain research and microbiological applications, particularly in blood culture systems where heparin or EDTA may inhibit microbial growth or interfere with downstream assays. However, the choice of anticoagulant should be validated for each specific application, as SPS has its own activity profile including anti-complementary and anti-lysozyme effects that may be advantageous or undesirable depending on experimental context.

How do I obtain a Certificate of Analysis or Safety Data Sheet for SKU P755560?

Certificates of Analysis (CoA) and Safety Data Sheets (SDS) for Polyanetholesulfonic acid sodium salt (SKU P755560) are available through the Aladdin Scientific website product page or by contacting Aladdin Scientific customer service directly. Please have your lot number ready when requesting a lot-specific CoA.

References

1. Murray PR, et al. Manual of Clinical Microbiology. ASM Press. (General reference for SPS use in blood culture media.)
2. Aladdin Scientific Product Page: Polyanetholesulfonic acid sodium salt, SKU P755560.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.