1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Thermoelectric materials comprise a wide range of solid compounds distinguished by their ability to convert thermal and electrical energy. This property gives rise to two distinct technological applications: the development of temperature gradients for heating and cooling devices and the ...
Quantum dots are tiny particles or nanocrystals of a semiconducting material with diameters in the range of 2-10 nanometers (10-50 atoms). They were first discovered in 1980. They display unique electronic properties, intermediate between those of bulk semiconductors and discrete molecules, that ...
In general terms, cultured cells require a sterile environment and a supply of nutrients for growth. In addition, the culture environment should be stable in terms of pH and temperature. Over the last 60 years, various defined basal media types have been developed and are now available ...
Materials featuring specially engineered porosity on the nanoscale hold significant applications across various domains such as optics, catalysis, drug delivery systems, coatings, cosmetics, bio-separation, diagnostics, gas-separation, and nanotechnology. Nanoporous materials comprise either an ...
we have noticed that in addition to monoclonal antibodies (which have little or no sialylation on their Fc portion), many more sialylated glycoproteins are regularly being developed. Examples include Fc fusion proteins, hormones (such as EPO), vaccines and clotting factors. Since sialic acids ...
Sialic acid analysis is a regulatory requirement laid out in the ICH Q6B guidelines for characterisation of biopharmaceuticals. In particular, determination of relative levels of human and non-human type sialic acids (Neu5Ac/NANA and Neu5Gc/NGNA respectively) is important since some patients ...
One-pot reductive amination of aldehydes and ketones is an important transformation in organic chemistry, and several common reducing agents are available for the direct conversion of carbonyl products into amines. However, many of these reagents have limitations (i.e., require significant ...
Sulfur (VI) fluoride exchange (SuFEx) has been identified as the next click chemistry reaction owing to the balanced properties of fluoride bonding to hydrogen and sulfur (VI). SuFEx building blocks provide “connective” chemistry that will find wide utility in applications such as chemical ...
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.1 The absence of exogenous metal catalysts makes these reactions suitable for the in vivo applications of bioorthogonal ...
