Glaucocalyxin A - 10mM in DMSO , CAS No.79498-31-0

CAS: 79498-31-0 Cat. No.: G655210 Formula: C₂₀H₂₈O₄ Molecular Weight: 332.43 PubChem CID: 10471963

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect

In Vitro

Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PI3K

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effec

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C[C@@]12CCC(=O)C([C@H]1C[C@H]([C@]34[C@H]2CC[C@H]([C@H]3O)C(=C)C4=O)O)(C)C
• Alternate CAS: 79498-31-0
• PubChem CID: 10471963
• MeSH Entry Terms: (7R,14R)-ent-7,14,dihydroxy-(-)-kaur-16-en-3,15-dione;glaucocalyxin A
• Molecular Weight: 332.43

Associated Targets(Human)

GP6 Tchem Platelet glycoprotein VI (2 Activities)

Discover Target: GP6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 79498-31-0, the molecular formula is C20H28O4, and the molecular weight is 332.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.