GLP-26 - 10mM in DMSO , CAS No.2133017-36-2

CAS: 2133017-36-2 Cat. No.: G656897 Molecular Weight: 373.35 PubChem CID: 130408536

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system ( IC 50 =3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.

In Vitro

GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV\nwild type, with EC 50 values of 0.7 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HepNTCP-DL cells Concentration: 0.7-1.7 μM Incubation Time: 3 days Result: Reduced secreted HBeAg in HepNTCP-DL cells.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system ( IC 50 =3 nM), and reduces cccDNA by >90% at 1 μM.\nGLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=C(N(C(=C1C(=O)C(=O)NCC#C)C)C)C(=O)NC2=CC(=C(C=C2)F)F
• PubChem CID: 130408536
• Molecular Weight: 373.35