Gly MCA - ≥95% , CAS No.66225-78-3

CAS: 66225-78-3 Cat. No.: G286558 Formula: C₂₆H₄₃NO₆ Molecular Weight: 465.62 PubChem CID: 131675923

GRADE & PURITY ≥95%

Synonyms

Gly-MCA | GβMCA | Glycine-β-muricholic Acid | N-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

GβMCA is an intestine-selective antagonist of the farnesoid X receptor (FXR) and the glycine-conjugatedform of the murine-specific primary bile acid β-muricholic acid (Item No. 20287).1,2 It inhibits expression ofthe FXR target genes Shp and Fgf15 induced by the FXR ligands chenodeoxycholic acid (Item No. 10011286)and GW 4064 (Item No. 10006611) in Caco-2 cells when used at a concentration of 100 μM. GβMCA isresistant to hydrolysis by fecal bile salt hydrolase (BSH) isolated from gut microbiota, indicating gut stability.Dietary administration of GβMCA (10 mg/kg) decreases Shp and Fgf15 mRNA expression in ileum, but notliver, and reduces ceramide levels and expression of the ceramide synthesis-related genes Sptlc2, Sptlc3,Cers2, Cers4, Degs1, Degs2, Smpd3, and Smpd4 in ileum of mice with high-fat diet-induced obesity and db/dbmice. It also prevents weight gain, reduces blood glucose levels, and increases insulin sensitivity as well asprevents development of cholestasis and necrotic lesions in liver of mice with high-fat diet-induced obesity.

Specifications

Synonyms

Gly-MCA | GβMCA | Glycine-β-muricholic Acid | N-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metaboli

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2C(C(C4C3(CCC(C4)O)C)O)O)C
• IUPAC Name: 2-[[(4R)-4-[(3R,5R,6S,7R,10R,13R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid
• InChIKey: ZQYUKJFJPJDMMR-DLUUSONCSA-N
• INCHI: 1S/C26H43NO6/c1-14(4-7-20(29)27-13-21(30)31)16-5-6-17-22-18(9-11-25(16,17)2)26(3)10-8-15(28)12-19(26)23(32)24(22)33/h14-19,22-24,28,32-33H,4-13H2,1-3H3,(H,27,29)(H,30,31)/t14-,15-,16?,17?,18?,19+,22?,23+,24-,25-,26-/m1/s1
• PubChem CID: 131675923
• Molecular Weight: 465.62

Chemical and Physical Properties

• Solubility: DMF: 30 mg/ml；DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml；DMSO: 20 mg/ml；Ethanol: 20 mg/ml

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 66225-78-3, the molecular formula is C??H??NO?, and the molecular weight is 465.62 g/mol. InChIKey ZQYUKJFJPJDMMR-DLUUSONCSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.