GNE-477 - ≥98% , CAS No.1032754-81-6
In stock
SKU
G413496
p110α Selective Inhibitors
Information
GNE-477 is a potent and efficacious dualPI3K/mTORinhibitor with an IC50 of 4 nM for PI3Kα and Kiappof 21 nM for mTOR.
Targets
PI3Kα (Cell-free assay); mTOR (Cell-free assay); mTOR (Cell-free assay) 4 nM; 21 nM(Ki app); 21 nM(Ki app)
More Information
| CAS | 1032754-81-6 |
|---|---|
| Synonyms | AKOS027420931 | 5-[7-methyl-6-[(4-methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine | UNII-0E8LA9H0RY | GNE-477 | s6516 | EX-A2063 | Q27236667 | BCP07720 | A14114 | BDBM50315907 | SCHEMBL1180950 | 0E8LA9H0R |
| Specifications & Purity | ≥98% |
| Storage | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information GNE-477 is a potent and efficacious dualPI3K/mTORinhibitor with an IC50 of 4 nM for PI3Kα and Kiappof 21 nM for mTOR. Targets PI3Kα (Cell-free assay); mTOR (Cell-free assay); mTOR (Cell-free assay) 4 nM; 21 nM(Ki app); 21 nM(Ki app) |
| Pubchem Sid | 504770016 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504770016 |
| Solubility | Solubility (25°C) In vitro DMSO: 25 mg/mL (49.54 mM); Water: Insoluble; Ethanol: Insoluble; |
| PubChem CID | 25207689 |
| Molecular Formula | C21H28N8O3S2 |
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