GNF2133 - Moligand™,≥98% , CAS No.2561414-56-8

CAS: 2561414-56-8 Cat. No.: G646983 Formula: C₂₄H₃₀N₆O₂ Molecular Weight: 434.53

GRADE & PURITY Moligand™, ≥98%

Synonyms

4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

In Vivo

GNF2133 (30 mg/kg; p.o.) shows good oral absorption with oral bioavailability of 22.3%.

GNF2133 (30 mg/kg; p.o.; once a day for 5 days) shows the ability to proliferate β-cells in vivo.

GNF2133 (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion in RIP-DTA mice.

IC50 & Target

DYRK1,DYRK1A(0.0062 μM (IC50)),GSK3β(>50 μM (IC50))

Specifications

Synonyms

4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide

Specifications & Purity

Moligand™,≥98%

Biochemical and Physiological Mechanisms

GNF2133 is a potent and selective DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capa

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 434.53

Chemical and Physical Properties

• Solubility: DMSO : 4 mg/mL (9.21 mM; ultrasonic and warming and heat to 60°C)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2561414-56-8, the molecular formula is C24H30N6O2, and the molecular weight is 434.53 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.