GppNHp - ≥95% , CAS No.64564-03-0

CAS: 64564-03-0 Cat. No.: G276465 Molecular Weight: 545.93 PubChem CID: 135889524

GRADE & PURITY ≥95%

Synonyms

DTXSID30657541 | Tetralithium 2-amino-9-[5-O-({[(phosphonatoamino)phosphinato]oxy}phosphinato)pentofuranosyl]-3,9-dihydro-6H-purin-6-one | 5'-Guanylylimidodiphosphate Tetralithium Salt | Tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Synonyms

DTXSID30657541 | Tetralithium 2-amino-9-[5-O-({[(phosphonatoamino)phosphinato]oxy}phosphinato)pentofuranosyl]-3, 9-dihydro-6H-purin-6-one | 5'-Guanylylimidodiphosphate Tetralithium Salt | Tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3, 4-dihydroxyoxolan-2

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg 2+ . Forms stable Ras complexes.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504773451
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773451
• Canonical Smiles: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
• IUPAC Name: tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
• InChIKey: NUKFMILQQVRELO-UHFFFAOYSA-J
• INCHI: 1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4
• Isomeric SMILES: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
• PubChem CID: 135889524
• Molecular Weight: 545.93

Chemical and Physical Properties

• Solubility: Soluble in water to 75 mM

References

1. Liu Chuqi, Liu Dexiang, Zheng Xiang, Guan Jiali, Zhou Xinyan, Zhang Haikun, Wang Shen, Li Qiubai, Lu Gan, He Jun, Ma Cong.  (2025)  Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.  Nature Communications,  16  (1): (1-24).  [PMID:41083534] [10.1038/s41467-025-64149-9]