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HeE1-2Tyr - ≥96% , CAS No.2245195-67-7
AVAILABLE TO ORDER
GRADE & PURITY ≥96%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥96% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro
In Vitro
HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC 50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC 50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM. Additionally, upon infection of human HEK 293 cells (CC 50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC 50 values ranging from 3.9 to 12 µM. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Flavivirus RNA dependent RNA polymerases (RdRp), SARS-CoV-2 RdRps>
Specifications
Specifications & Purity
≥96%
Biochemical and Physiological Mechanisms
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile , Dengue and SARS-CoV-2 RdRps ( IC 50 of 27.6 µM) activity in vitro.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥96%
Names and Identifiers
| Molecular Weight | 582.67 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (171.62 mM; Need ultrasonic) |
|---|
Solution Calculators
Reviews
Customer Reviews
Frequently Asked Questions
What is the purity of this product?
This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2245195-67-7, the molecular formula is C33H30N2O6S, and the molecular weight is 582.67 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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