Histamine dihydrochloride - Moligand™, ≥98% , CAS No.56-92-8

CAS: 56-92-8 Cat. No.: H110868 Molecular Weight: 184.07 Beilstein Registry Number: 3624116 EC Number: 200-298-4 PubChem CID: 5818
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
Dr. Freds Miracle Rub | Glucosamine Cream EXTRA STRENGTH | ROPANA Pain Relief Cream | Histamine 2HCl | HY-B0722 | Histamine dihydrochloride; 2-(1H-imidazol-4-yl)ethanamine dihydrochloride | HISTAMINE, DIHYDROCHLORIDE | HISTAMINE HYDROCHLORIDE [WHO-DD] | M
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5g
H110868-5g
≥10
$10.90
10g
H110868-10g
1
$15.90
25g
H110868-25g
5
$25.90
100g
H110868-100g
5
$59.90
500g
H110868-500g
1
$219.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Natural isomer of dopamine direct precursor, product of tyrosine hydroxylase.

Specifications

Synonyms
Dr. Freds Miracle Rub | Glucosamine Cream EXTRA STRENGTH | ROPANA Pain Relief Cream | Histamine 2HCl | HY-B0722 | Histamine dihydrochloride; 2-(1H-imidazol-4-yl)ethanamine dihydrochloride | HISTAMINE, DIHYDROCHLORIDE | HISTAMINE HYDROCHLORIDE [WHO-DD] | M
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Endogenous histamine receptor agonist. Involved in the inflammatory response, in addition to regulating physiological function in the gut. Acts as a neurotransmitter and shows vasodilatory and bronchoconstrictory activity.
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Pubchem Sid504750945
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750945
Canonical SmilesC1=C(NC=N1)CCN.Cl.Cl
IUPAC Name2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
InChIKeyPPZMYIBUHIPZOS-UHFFFAOYSA-N
INCHI1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
Isomeric SMILES C1=C(NC=N1)CCN.Cl.Cl
WGK Germany 2
RTECS MS1575000
PubChem CID 5818
Molecular Weight 184.07
Beilstein 3624116
Reaxy-Rn 3624116

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic nitrogen compounds
ClassOrganonitrogen compounds
SubclassAmines
Intermediate Tree Nodes Primary amines
Direct Parent2-arylethylamines
Alternative Parents Aralkylamines  Imidazoles  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Monoalkylamines  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents 2-arylethylamine - Aralkylamine - Heteroaromatic compound - Imidazole - Azole - Azacycle - Organoheterocyclic compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Primary aliphatic amine - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FPR2 Tchem Lipoxin A4 receptor (3472 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hrh4 Histamine H4 receptor (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aplnr Apelin receptor (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot NumberCertificate TypeDateItem
E2223153Certificate of AnalysisMar 11, 2026 H110868
H2504387Certificate of AnalysisMay 21, 2025 H110868
H2504386Certificate of AnalysisMay 21, 2025 H110868
H2504352Certificate of AnalysisMay 21, 2025 H110868
H2504249Certificate of AnalysisMay 21, 2025 H110868
F2623082Certificate of AnalysisMay 21, 2025 H110868
C2131268Certificate of AnalysisJan 16, 2025 H110868
E2015101Certificate of AnalysisMar 14, 2024 H110868
G2311068Certificate of AnalysisJul 20, 2023 H110868
I2402429Certificate of AnalysisApr 10, 2023 H110868
D2323147Certificate of AnalysisApr 10, 2023 H110868
D2323143Certificate of AnalysisApr 10, 2023 H110868
D2323142Certificate of AnalysisApr 10, 2023 H110868
D2323139Certificate of AnalysisApr 10, 2023 H110868
D2323138Certificate of AnalysisApr 10, 2023 H110868
D2323135Certificate of AnalysisApr 10, 2023 H110868
E2223156Certificate of AnalysisMar 14, 2022 H110868
E2223157Certificate of AnalysisMar 14, 2022 H110868
E2223152Certificate of AnalysisMar 14, 2022 H110868

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Chemical and Physical Properties
SolubilityVery soluble in water and methanol. Soluble in ethanol. , Very soluble in water and methanol. Soluble in ethanol.
Melt Point(°C)246°C
Molecular Weight184.060 g/mol
XLogP3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass183.033 Da
Monoisotopic Mass183.033 Da
Topological Polar Surface Area54.700 Ų
Heavy Atom Count10
Formal Charge0
Complexity64.700
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count3
Documents & Articles
Citations of This Product
References
1. Shijin Xiong, Xiaoyan Xu, Qiaozhen Liu, Yazhou Xu, Hongbing Ren, Tao Xiong, Mingyong Xie.  (2023)  Integrated metatranscriptomics and metabolomics revealed the metabolic pathways of biogenic amines during Laotan Suancai fermentation.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2023.103517]
2. Furong Jin, Xinyue Yin, Yang Wan, Jiukai Zhang, Jindi Wang, Xiangbo Fu, Tianxin Fu, Buwei Liu, Yongshi Chen, Bo Tian, Zhibiao Feng.  (2023)  Ultrasonic–microwave synergistic supramolecular solvent liquid–liquid microextraction of trace biogenic amines in fish and beer based on solidification of floating organic droplet.  FOOD CHEMISTRY,      [PMID:37516607] [10.1016/j.foodchem.2023.136965]
3. Shan Xu, Peifang Chen, Xichi Lin, Imran Mahmood Khan, Xiaoyuan Ma, Zhouping Wang.  (2022)  Controllable synthesis of flower-like AuNFs@ZIF-67 core-shell nanocomposites for ultrasensitive SERS detection of histamine in fish.  ANALYTICA CHIMICA ACTA,      [PMID:36641156] [10.1016/j.aca.2022.340776]
4. Jian-Jun Zhong, Liping Xia, Liuru Xue, Boyu Liu, Lingling Zhao, Hua Ye, Zhanming Li.  (2022)  Analytical method for histamine, urocanic acid isomers, and their precursor histidine in fish sauce based on precolumn dansylation and high-performance liquid chromatography.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2022.109566]
5. Yixuan Fan, Runze Yu, Yongfeng Chen, Yufeng Sun, Geoffrey I. N. Waterhouse, Zhixiang Xu.  (2022)  A Capillary Electrophoresis Method Based on Molecularly Imprinted Solid-Phase Extraction for Selective and Sensitive Detection of Histamine in Foods.  MOLECULES,  27  (20): (6987).  [PMID:36296580] [10.3390/molecules27206987]
6. Xirui Chen, Yujie Tu, Song Cheng, Xujing Guo, Tianying Lu, Yuqian Guo, Xiaolin Huang, Yonghua Xiong, Ben Zhong Tang.  (2022)  A colorimetric and ratiometric fluorescent paper chip for biogenic amine monitoring based on a simple pH-sensitive AIEgen.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.137928]
7. Xujing Guo, Xirui Chen, Rui Chen, Yujie Tu, Tianying Lu, Yuqian Guo, Liang Guo, Yonghua Xiong, Xiaolin Huang, Ben Zhong Tang.  (2022)  Ratiometric Monitoring of Biogenic Amines by a Simple Ammonia-Response Aiegen.  Foods,  11  (7): (932).  [PMID:35407018] [10.3390/foods11070932]
8. Xiaofeng Wang, Yongfeng Chen, Runze Yu, Ruiqiang Wang, Zhixiang Xu.  (2021)  A sensitive biomimetic enzyme-linked immunoassay method based on Au@Pt@Au composite nanozyme label and molecularly imprinted biomimetic antibody for histamine detection.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2021.1978945]
9. Chen Chen, Ximo Wang, Geoffrey I.N. Waterhouse, Xuguang Qiao, Zhixiang Xu.  (2021)  A surface-imprinted surface-enhanced Raman scattering sensor for histamine detection based on dual semiconductors and Ag nanoparticles.  FOOD CHEMISTRY,      [PMID:34488130] [10.1016/j.foodchem.2021.130971]
10. Yiming Zhang, Jinsheng Yu, Shuyu Lai, Jian Song, Xiaomei Wu, Dingnan Wang, Linjiang Pang, Tingting Chai.  (2020)  Rapid determination of histamine level in seafood using read-out strips based on high-performance thin layer chromatography modified with self-visualization nanomaterials.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2020.107816]
11. Yi-Fang Li, Zheng-Zhong Lin, Cheng-Yi Hong, Zhi-Yong Huang.  (2020)  Histamine detection in fish samples based on indirect competitive ELISA method using iron-cobalt co-doped carbon dots labeled histamine antibody.  FOOD CHEMISTRY,      [PMID:33601655] [10.1016/j.foodchem.2020.128812]
12. Xiaofeng Wang, Xiaoqing Song, Lin Si, Longhua Xu, Zhixiang Xu.  (2020)  A novel biomimetic immunoassay method based on Pt nanozyme and molecularly imprinted polymer for the detection of histamine in foods.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2020.1807916]
13. Yangyang Xu, Suya Fu, Feiyang Liu, Haiyin Yu, Jiangang Gao.  (2018)  Multi-stimuli-responsiveness of a novel polydiacetylene-based supramolecular gel.  Soft Matter,  14  (39): (8044-8050).  [PMID:30255918] [10.1039/C8SM01515E]
14. Lingling Zhao, Xinqi Pan, Jie Shi, Hua Ye, Huanan Guan, Yuanxin Guo, Jian-Jun Zhong.  (2025)  Formation of urocanic acid versus histamine from histidine in chub mackerel (Scomber japonicus) fillets as determined by a mixed-mode HPLC method.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2025.107431]
15. Han Huang, Yudi Liu, Yanjun Tong, Wei Zhao, Xiaomei Lyu, Ruijin Yang.  (2024)  High-Pressure Processing for Pickled Crabs: Safety, Quality and Flavor Assessment and Correlation Analysis of Spoilage Indicators.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.105227]
16. Dongfei Zhang, Ao Wang, Wenkai Liu, Ao Zhen, Jiehua Li, Feng Luo, Xianglong Han, Zhen Li, Hong Tan.  (2024)  Self-Catalysis Highly Reversible Imidazole-Based Dynamic Covalent Polyurethane-Ureas.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.4c00149]
17. Cheng-yuan Li, Mei Su, Yun-yi Yan, Lin Zhou, Lu-yao Ao, Wei-rong Fang, Yun-man Li.  (2017)  KFP-H008 blocks gastric acid secretion through inhibiting H+-K+-ATPase.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:28629736] [10.1016/j.ejphar.2017.06.020]
18. Jinxiu Guo, Yu Chen, Lizhi Zhao, Ping Sun, Hongli Li, Lei Zhou, Xiayan Wang, Qiaosheng Pu.  (2016)  A strategy to modulate the electrophoretic behavior in plastic microchips using sodium polystyrene sulfonate.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:27908499] [10.1016/j.chroma.2016.11.042]
19. Shiyan Liu, Xuefeng Zhang, Xin Gong, Jinxin Yu, Tao Lin, Qian Xiang, Xinnian Zeng, Jiali Liu.  (2025)  molecular and pharmacological characterization of the dopamine receptors in the oriental fruit fly, Bactrocera dorsalis.  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY,      [PMID:40245998] [10.1016/j.ibmb.2025.104312]
20. Li Sisi, Luo Kaitong, Zhou Yali, Wang Junhao, Zhang Zhen, Liu Zhao-Qing, Chen Yibo.  (2026)  Substitution of free halide ions unlocks responsive photoluminescence switching in manganese-based metal halides.  Light-Science & Applications,  15  (1): (105).  [PMID:41639042] [10.1038/s41377-025-02161-w]
21. Zehao Ye, Jiying Xu, Yi Chen, Pengfei Zhang.  (2026)  Electrochemically Modulated Optical Imaging Sensors Integrated with Microfluidics.  Biosensors-Basel,  16  (2): (86).  [PMID:41744705] [10.3390/bios16020086]
22. Yanan Liu, Yuhao Huang, Qileng Aori, Yu Wang, Sai Zhao, Zhen-Lin Xu.  (2026)  A sustained-release antibacterial gelatin hydrogel based on metal-phenolic networks for long-term preservation of prefabricated meat.  FOOD CHEMISTRY,      [PMID:] [10.1016/j.foodchem.2026.149080]
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