Hydroxychloroquine sulfate - 10mM in Water , Toll-like receptor 9 antagonist, CAS No.747-36-4, Toll-like receptor 9 antagonist

CAS: 747-36-4 Cat. No.: H425807 Molecular Weight: 433.95 EC Number: 212-019-3
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GRADE & PURITY 10mM in Water
Synonyms
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt) | FT-0669460 | HYDROXYCHLOROQUINE SULFATE [JAN] | NCGC00159483-04 | Plaquenil | AI3-52706 | Hydroxycloroquine sulfate, analytical standard | 747-36-4 (sulfate) | HYDROXYCHLOR
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
H425807-1ml
1

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Why this grade

10mM in Water for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt) | FT-0669460 | HYDROXYCHLOROQUINE SULFATE [JAN] | NCGC00159483-04 | Plaquenil | AI3-52706 | Hydroxycloroquine sulfate, analytical standard | 747-36-4 (sulfate) | HYDROXYCHLOR
Specifications & Purity
10mM in Water
Biochemical and Physiological Mechanisms
Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used as
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Mechanism of action
Toll-like receptor 9 antagonist
Names and Identifiers
Canonical SmilesCCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
IUPAC Name2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
InChIKeyJCBIVZZPXRZKTI-UHFFFAOYSA-N
INCHI1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
Isomeric SMILES CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
WGK Germany 3
RTECS KK3342500
Molecular Weight 433.95
Reaxy-Rn 7242072
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7242072&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassQuinolines and derivatives
SubclassAminoquinolines and derivatives
Intermediate Tree Nodes Not available
Direct Parent4-aminoquinolines
Alternative Parents Chloroquinolines  Secondary alkylarylamines  Aminopyridines and derivatives  Organic sulfuric acids  Benzenoids  Aryl chlorides  Heteroaromatic compounds  Trialkylamines  1,2-aminoalcohols  Azacyclic compounds  Primary alcohols  Organopnictogen compounds  Organochlorides  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 4-aminoquinoline - Haloquinoline - Chloroquinoline - Aminopyridine - Sulfuric acid - Secondary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Pyridine - Benzenoid - Heteroaromatic compound - Organic sulfuric acid or derivatives - Tertiary aliphatic amine - Tertiary amine - 1,2-aminoalcohol - Azacycle - Secondary amine - Alkanolamine - Organonitrogen compound - Organochloride - Organopnictogen compound - Organic oxygen compound - Organohalogen compound - Alcohol - Amine - Organic nitrogen compound - Organic oxide - Organooxygen compound - Primary alcohol - Hydrocarbon derivative - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC2A1 Tchem Glucose transporter (14755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ht1 Hexose transporter 1 (14071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Sensitivitylight sensitive
Molecular Weight434.000 g/mol
XLogP3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass433.144 Da
Monoisotopic Mass433.144 Da
Topological Polar Surface Area131.000 Ų
Heavy Atom Count28
Formal Charge0
Complexity413.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Citations of This Product
References
1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo.  (2023)  Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37422124] [10.1016/j.jconrel.2023.07.003]
2. Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu, He Lian.  (2023)  A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.143730]
3. Wang Shuqi, Zhou Li, Tian Hailong, Li Bowen, Su Miao, Li Qiong, Nice Edouard C., Huang Canhua, Shao Jichun, He Tao.  (2023)  Site-specific nanomodulator capable of modulation apoptosis for enhanced colorectal cancer chemo-photothermal therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  21  (1): (1-15).  [PMID:36670444] [10.1186/s12951-023-01779-5]
4. Haojie Zhang, Yunxiang He, Yajing Zhang, Jiezhou Pan, Tingxu Guo, Huijun Huang, Mengyuan Dai, Jiaojiao Shang, Guidong Gong, Junling Guo.  (2024)  Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin.  BIOMACROMOLECULES,      [PMID:38574372] [10.1021/acs.biomac.4c00010]
5. Chunmei Ma, Qicheng Zhang, Yan Wang, Dihua Li, Huiying Zhang, Qiang Jia, Wei Zheng, Jian Tan, Ke Xu, Lei Yang, Zhaowei Meng.  (2025)  Effect of Benzyl Isothiocyanate on Anaplastic Thyroid Cancer Evaluated by Network Pharmacology Combined with Experiments.  ACS Omega,      [PMID:40160743] [10.1021/acsomega.4c08388]
6. Yang Ya-qi, Liu Yi-jun, Qiao Wen-xuan, Jin Wei, Zhu Shun-wei, Yan Yu-xi, Luo Qiong, Xu Qiang.  (2024)  Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation.  ACTA PHARMACOLOGICA SINICA,      [PMID:38744938] [10.1038/s41401-024-01288-7]
7. Akbar Mamatali, Dedong Wu, Haijiao Xie, Pengfei Xiao.  (2024)  Mesoporous cobalt-manganese layered double hydroxides promote the activation of calcium sulfite for degradation and detoxification of metronidazole.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:38613974] [10.1016/j.jcis.2024.04.056]
8. Yushuang Wei, Wenwen Li, Rong Xu, Cheng Xu, Xiangyang Li, Ning Li, Fengdan Xu, Kai Yang, Bing Yuan.  (2025)  Multivalent Co-assembly of LL37-CpG nanoparticles: Enhanced immune response through activating multiple cell internalization pathways.  Materials Today Bio,      [PMID:40621182] [10.1016/j.mtbio.2025.102011]
9. Duan Xirui, Tian Hailong, Peng Peilan, Zhou Ping, Ding Ning, Liu Guowen, Bentley Gary T., Huang Canhua, Yang Jun, Xie Ke.  (2025)  Hyaluronic acid-tailored prodrug nanoplatforms for efficiently overcoming colorectal cancer chemoresistance and recurrence by synergistic inhibition of cancer cell stemness.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-19).  [PMID:40660238] [10.1186/s12951-025-03484-x]
10. Lihui Zhang, Dahui Liu, Qiyong Jiang, Qing Sun.  (2025)  Edible coating of Chrysanthemum morifolium by-products derived carbon quantum dots alleviated postharvest quality deterioration of Gastrodia elata through regulating phenylpropanoid pathway.  Food Packaging and Shelf Life,      [PMID:] [10.1016/j.fpsl.2025.101602]
11. Su Dehui, Ma Ruiqiong, Su Huina, Tan Cheng, Zhu Ye, Liu Yanhua, Jiang Xiaolin, Sun Xiaowan, Lei Tonghao, Zhang Mengyu, Lin Shengrui, Qi Yongfen, Yang Xin.  (2026)  Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway.  npj Aging,      [PMID:41839900] [10.1038/s41514-026-00359-9]
12. Tingxu Guo, Yawen Huang, Wanmeng Liu, Shaojian Lin, Jianwu Lan, Jiaojiao Shang.  (2026)  A Stable Metal–Polyphenol Network-Functionalized Black Phosphorus Nanoplatform for Multidrug-Loading and Controllable Chemo–Photothermal Therapy.  Small,      [PMID:] [10.1002/smll.202512969]
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