Hypotaurine - ≥98% , CAS No.300-84-5

CAS: 300-84-5 Cat. No.: H303371 Molecular Weight: 109.14 EC Number: 428-720-4

GRADE & PURITY ≥98%

Synonyms

Cystaminesulfinic acid | AKOS006340932 | AS-60017 | 2-amino-Ethanesulfinate | 2-Aminoethylsulfinic acid | NCGC00091443-05 | UNII-5L08GE4332 | NCGC00024496-02 | 2-aminoethane-1-sulfinicacid | LP00573 | A815612 | HY-100803 | SCHEMBL15177935 | NCGC00015499-0

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

Cystaminesulfinic acid | AKOS006340932 | AS-60017 | 2-amino-Ethanesulfinate | 2-Aminoethylsulfinic acid | NCGC00091443-05 | UNII-5L08GE4332 | NCGC00024496-02 | 2-aminoethane-1-sulfinicacid | LP00573 | A815612 | HY-100803 | SCHEMBL15177935 | NCGC00015499-0

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Endogenous inhibitory amino acid.Hypotaurine, a cystamine analog, is a precursor for taurine synthesis. It acts as an antioxidant and singlet oxygen scavenger, thus protecting cells from oxidative damage. Hypotaurine has been reported to play an important

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504756634
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756634
• Canonical Smiles: C(CS(=O)O)N
• IUPAC Name: 2-aminoethanesulfinic acid
• InChIKey: VVIUBCNYACGLLV-UHFFFAOYSA-N
• INCHI: 1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
• Isomeric SMILES: C(CS(=O)O)N
• Molecular Weight: 109.14
• Reaxy-Rn: 1743127
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1743127&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Sulfinic acids and derivatives
      • Subclass Sulfinic acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Sulfinic acids and derivatives
• Subclass: Sulfinic acids
• Intermediate Tree Nodes: Not available
• Direct Parent: Sulfinic acids
• Alternative Parents: Alkanesulfinic acids Organosulfur compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Sulfinic acid - Alkanesulfinic acid - Alkanesulfinic acid or derivatives - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organosulfur compound - Organonitrogen compound - Primary aliphatic amine - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as sulfinic acids. These are compounds containing a sulfinic acid functional group, with the general structure RS(=O)OH (R = organyl, not H).
• External Descriptors: aminosulfinic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARSA Tbio Cerebroside-sulfatase (655 Activities)

Discover Target: ARSA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: None, Max Conc. mM: 100
• Molecular Weight: 109.150 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 109.02 Da
• Monoisotopic Mass: 109.02 Da
• Topological Polar Surface Area: 82.500 Ų
• Heavy Atom Count: 6
• Formal Charge: 0
• Complexity: 55.500
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Zhi-Peng Zhu, Jian-Xiang Yu, Xuan-Huan Qiao, Zhi-Fang Yu, Ai-Sheng Xiong, Miao Sun.  (2023)  Hydrogen sulfide delays yellowing and softening, inhibits nutrient loss in postharvest celery.  SCIENTIA HORTICULTURAE,      [PMID:] [10.1016/j.scienta.2023.111991]

2. Jia Honglei, Chen Sisi, Liu Dan, Liesche Johannes, Shi Cong, Wang Juan, Ren Meijuan, Wang Xiaofeng, Yang Jun, Shi Wei, Li Jisheng.  (2018)  Ethylene-Induced Hydrogen Sulfide Negatively Regulates Ethylene Biosynthesis by Persulfidation of ACO in Tomato Under Osmotic Stress.  Frontiers in Plant Science,      [PMID:30386366] [10.3389/fpls.2018.01517]

3. Zhang Zhi-Hao, Li Ming-Hua, Liu Dan, Chen Hua, Chen Dan-Qian, Tan Ning-Hua, Ma Shuang-Cheng, Zhao Ying-Yong.  (2018)  Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease.  Frontiers in Pharmacology,      [PMID:30271345] [10.3389/fphar.2018.01029]

4. Miao Sun, Huan-Xuan Qiao, Tao Yang, Peng Zhao, Jun-Hao Zhao, Jia-Ming Luo, Hai-Ye Luan, Xiang Li, Sheng-Cai Wu, Ai-Sheng Xiong.  (2024)  Hydrogen sulfide alleviates cadmium stress in germinating carrot seeds by promoting the accumulation of proline.  JOURNAL OF PLANT PHYSIOLOGY,      [PMID:39316927] [10.1016/j.jplph.2024.154357]

5. Yi Zhang, Hao Guo, Gang Wang, Fang Lan, Shiyong Zhang.  (2025)  Poly-Lipoic Acid Trisulfide Particles: A New Donor With Continuous and Steady H2S Supply.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202511440]